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anti-Mouse (Murine) FGF19 Antibodies:
anti-Rat (Rattus) FGF19 Antibodies:
anti-Human FGF19 Antibodies:
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Human Monoclonal FGF19 Primary Antibody for ELISA, WB - ABIN523342
Shang, Guo, Honda, Saumoy, Salen, Xu: FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels. in Journal of lipid research 2013
The elevation in circulating levels of adiponectin (show ADIPOQ Antibodies) and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT (show MNT Antibodies) knockout mice.
This study reveals SHP (show LAMC1 Antibodies) as a global transcriptional partner of SREBP-2 (show SREBF2 Antibodies) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19.
Protective effects of farnesoid X receptor (show xpr1 Antibodies) on hepatic lipid accumulation are mediated by hepatic FXR (show NR1H4 Antibodies) and are independent of intestinal FGF15 signaling.
In mice with humanized livers human hepatocytes do not recognize FGF-15 produced by mouse intestine, resulting in up-regulation of bile acid synthesis enlargement of the bile acid pool, affecting the hepatostat.
Intestinal PPARalpha (show PPARA Antibodies)-UDP- Glucuronyltransferases and downstream FXR (show NR1H4 Antibodies)-FGF15 signalling play vital roles in control of bile acid homeostasis and the pathological development of colitis.
a direct role of intestinal FGF15/19 in the regulation of SI P450 (show POR Antibodies) expression and may have profound implications for the prediction of drug exposure in patients with compromised hepatic P450 (show POR Antibodies) function
findings implicate the brain in the antidiabetic action of systemic FGF19 and establish the brain's capacity to rapidly, potently, and selectively increase insulin (show INS Antibodies)-independent glucose disposal
Ileal Fibroblast Growth Factor-15 (FGF15) expression was significantly reduced in Asbt (show SLC10A2 Antibodies)(-/-)apoE (show APOE Antibodies)(-/-) mice and was inversely correlated with expression of hepatic cholesterol 7-hydroxylase (Cyp7a1 (show CYP7A1 Antibodies)).
HNF4alpha (show HNF4A Antibodies) and LRH-1 (show NR5A2 Antibodies) promote active transcription histone marks on the Cyp7a1 (show CYP7A1 Antibodies) promoter that are reversed by FGF19 in a SHP (show LAMC1 Antibodies)-dependent manner
Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha (show OSTALPHA Antibodies)(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression
Amplification of FGF19 was validated in independent LSCC samples. Furthermore, FGF19 stimulated LSCC cell growth in vitro. These data implicate FGF19 as a potential driver gene in LSCC with clinic characteristics as smoking.
FGF19 is able to enhance migration and invasion abilities of gastric cancer cells.
Bile acid and FGF19 levels increased after Roux-en-Y bypass, but not after intensive medial management in type 2 diabetic subjects who achieved similar improvement in glycemic control.
FGF19 correlates with severity of liver disease and can potentially serve as an indicator of chronic cholestatic liver injury.
Study shows that FGF19 can be secreted and promotes ovarian cancer progression such as proliferation and invasion by activating FGFR4 (show FGFR4 Antibodies).
Suggest a potential connection between gallbladder cholangiocyte-derived FGF19 and bile acid metabolism that could lead to metabolic dysregulation following cholecystectomy.
FGF-19 increment after OGL was positively associated with age, and negatively associated with abnormal glucose regulation and statin treatment
KL methylation is a characteristic of many breast cancer cases . However, the resulting or associated perturbation in FGFR4 (show FGFR4 Antibodies) expression, similar to FGF19, could be utilized as a biomarker for poor prognosis
The pathogenesis of intestinal failure associated liver disease is uncertain, we therefore investigated the role of FGF19 and pro-inflammatory cytokines has on this disease state.
In this review, we have reported the altered expression of FGF19 in non-alcoholic fatty liver disease and hepatocellular carcinoma; we find limited information on the role of FGF19 in other liver diseases
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
fibroblast growth factor 19
, fibroblast growth factor 15