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anti-Mouse (Murine) FLT3LG Antibodies:
anti-Human FLT3LG Antibodies:
anti-Rat (Rattus) FLT3LG Antibodies:
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Data show that FLT3 ligand (FLT3L) enhances thymopoiesis through increased survival and export of hematopoietic stem cell (Lin([minus])Sca1 (show ATXN1 Antibodies)(+)c-Kit (show KIT Antibodies)(+) [LSK (show LCK Antibodies)] cells via CXCR4 (show CXCR4 Antibodies) receptor regulation.
these results demonstrate that the lack of Flt3L mRNA expression in hematopoietic stem cells is yet another marker which further defines the status of long-term repopulating -hematopoietic stem cells
this study shows that ionizing radiation induces a decrease of CD8 (show CD8A Antibodies)+ dendritic cells and Th1 (show HAND1 Antibodies)/Th2 shift, which was reversed by Flt3 ligand treatment, suggesting a novel mechanism for radiation-induced immunosuppression
may be mediated by Flt3L- and MMP-9 (show MMP9 Antibodies)-dependent mobilization of dendritic cells
Bone marrow-derived CD117+ hematopoietic progenitor cells differentiate into thymic dendritic cells in the fetal thymus organ culture system in the presence of Flt3L.
Flt3L significantly contributes to innate lymphoid cells and Peyer's patches development by targeting lymphoid progenitor cells during fetal and adult life.
unlike G-CSF (show CSF3 Antibodies), Flt3 (show FLT3 Antibodies)-L had an indirect effect on EI macrophages, as it was not detected at the surface of EI macrophages or erythroid progenitors.
Study showed shown Flt3L-dependent accumulation of a population of DNGR-1(CLEC9A (show CLEC9A Antibodies))-EGFP+ CD45h CD11blow MHCII+ myeloid cells in the brain
Data indicate that Flt3 ligand knockout (Flt3L-/-) mice are unable to control infection with Toxoplasma gondii.
inhibition of the calcineurin-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo
it is likely that TGFbeta1 (show TGFB1 Antibodies) and FL, both abundantly produced by bone marrow stromal cells, function in a coordinated manner to render mixed-lineage leukemia gene-rearranged acute lymphoblastic leukemia cells chemoresistant
Pre-treatment serum levels of FLT3 (show FLT3 Antibodies)-L were higher than controls. FLT3 (show FLT3 Antibodies)-L correlated positively with all soluble angiogenic factors, as well with bone marrow microvascular density. Post-treatment FLT3 (show FLT3 Antibodies)-L decreased significantly in responders to therapy.
The immunohistochemical expression of caveolin-1 (show CAV1 Antibodies) and podocalyxin (show PODXL Antibodies) in lungs from rats challenged with a 2-kDa macrophage-activating lipopeptide (MALP-2) and Flt3L, was examined.
The Flt3L/CD135 (show FLT3 Antibodies) axis is active in rheumatoid arthritis
Flt3L enhances global T cell and humoral immunity as well as both the numbers and antigen capture capacity of migratory dendritic cells and classical lymphoid-resident dendritic cells
Administration of the hematopoietic growth factor (show IL-3 Antibodies) Flt3L to human subjects increases the frequency and absolute number of Treg cells.
Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis.
A novel dendritic cell(DC) progenitor regulatory pathway in which PGE (show LIPF Antibodies)(2) signaling through EP1 (show PTGER1 Antibodies)/EP3 (show PTGER3 Antibodies) receptors regulates Flt3 (show FLT3 Antibodies) expression and downstream STAT3 (show STAT3 Antibodies) activation and survivin (show BIRC5 Antibodies) expression, required for optimal progenitor survival and differentiation.
data demonstrate that the Flt3L/TK gene therapeutic approach can induce systemic immunological memory capable of recognizing a brain tumor neoantigen in a model of recurrent GBM
FLT3 ligand(FL) leads to further activation of FLT3 (show FLT3 Antibodies) mutants and is especially important in light of recent findings of elevated FL levels in acute myeloid leukemia (show BCL11A Antibodies) patients in response to chemotherapy.
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE\; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010
, flt3 ligand
, fms-related tyrosine kinase 3 ligand
, fms-like tyrosine kinase 3 ligand