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Browse our FLT4 Proteins (FLT4)

Full name:
Fms-Related Tyrosine Kinase 4 Proteins (FLT4)
On www.antibodies-online.com are 31 Fms-Related Tyrosine Kinase 4 (FLT4) Proteins from 14 different suppliers available. Additionally we are shipping FLT4 Antibodies (203) and FLT4 Kits (44) and many more products for this protein. A total of 287 FLT4 products are currently listed.
Synonyms:
6130401C07, AI323512, cb1059, Chy, Flk-1, Flk1, Flt-4, FLT41, Krd-1, LMPH1A, Ly73, PCL, sVEGFR-2, VEGFR-2, VEGFR-3, VEGFR2, Vegfr3
list all proteins Gene Name GeneID UniProt
FLT4 14257 P35917
FLT4 2324 P35916
FLT4 114110 Q91ZT1

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FLT4 Proteins (FLT4) by Origin

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Top referenced FLT4 Proteins

  1. Human FLT4 Protein expressed in Escherichia coli (E. coli) - ABIN2667606 : Cursiefen, Chen, Saint-Geniez, Hamrah, Jin, Rashid, Pytowski, Persaud, Wu, Streilein, Dana: Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 8 references for ABIN2667606

  2. Human FLT4 Protein expressed in Human Cells - ABIN2003423 : Pajusola, Aprelikova, Pelicci, Weich, Claesson-Welsh, Alitalo: Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors. in Oncogene 1994 (PubMed)
    Show all 5 references for ABIN2003423

  3. Mouse (Murine) FLT4 Protein expressed in Human Cells - ABIN2008007 : Tammela, Zarkada, Wallgard, Murtomäki, Suchting, Wirzenius, Waltari, Hellström, Schomber, Peltonen, Freitas, Duarte, Isoniemi, Laakkonen, Christofori, Ylä-Herttuala, Shibuya, Pytowski, Eichmann et al.: Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. ... in Nature 2008 (PubMed)
    Show all 5 references for ABIN2008007

More Proteins for FLT4 Interaction Partners

Mouse (Murine) Fms-Related Tyrosine Kinase 4 (FLT4) interaction partners

  1. demonstrated that Id1 (show ID1 Proteins) and E2-2 (show TCF4 Proteins) are critical regulators of EPCs function in vitro. Id1 (show ID1 Proteins) interacts with E2-2 (show TCF4 Proteins) and relieves the E2-2 (show TCF4 Proteins)-mediated repression of FGFR1 (show FGFR1 Proteins) and VEGFR2 (show KDR Proteins) expression to modulate EPCs functions

  2. Data suggest that expression of Notch-1 (show NOTCH1 Proteins) receptor in endothelial progenitor cells (EPC (show TCF21 Proteins)) in bone marrow is up-regulated in diabetic angiopathy (DA); signaling in EPC (show TCF21 Proteins) via Notch-1 (show NOTCH1 Proteins) receptor and VEGFA (show VEGFA Proteins)/VEGFR2 (show KDR Proteins) appears to be altered in DA.

  3. Collectively, these data suggest that VEGF (show VEGFA Proteins)/VEGFR2 (show KDR Proteins) signaling regulates germ cell proliferation and promotes testicular regeneration via direct action on germ cells and the enhancement of vascularization.

  4. this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8 (show LGALS8 Proteins)-dependent crosstalk among VEGF-C (show VEGFC Proteins), podoplanin (show PDPN Proteins) and integrin pathways plays a key role.

  5. administration of 0.3 IU/mL FSH (show BRD2 Proteins) during ovarian cryopreservation by vitrification can maintain ovarian survival during ovarian vitrification and increases the blood supply with avascular transplantation via upregulation of Cx43 (show GJA1 Proteins), Cx37 (show GJA4 Proteins), and VEGF (show VEGFA Proteins)/VEGFR2 (show KDR Proteins)

  6. The data provide new insights for the chaperone function of PDCL3 (show PDCL3 Proteins) in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 (show PDCL3 Proteins) expression and its effect on VEGFR-2 (show KDR Proteins).

  7. VEGFA (show VEGFA Proteins)-induced vascular leakage depends on signaling initiated via the VEGFR2 (show KDR Proteins) phosphosite Y949. Abolished Y949 signaling in the mutant Vegfr2 (show KDR Proteins)(Y949F/Y949F) leads to VEGFA (show VEGFA Proteins)-resistant endothelial adherens junctions.

  8. These findings together demonstrate the essential role of KDM4A (show KDM4A Proteins) and KDM4C (show KDM4C Proteins) in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 (show KDR Proteins) and VE-cadherin (show CDH5 Proteins) promoters, respectively

  9. VEGFA (show VEGFA Proteins)/VEGFR2 (show KDR Proteins) signaling may be essential for podocytes in a normal state.

  10. Tnfsf15 (show TNFSF15 Proteins), a cytokine produced largely by endothelial cells, facilitates lymphangiogenesis by up-regulating Vegfr3 gene expression in LECs, contributing to the maintenance of the homeostasis of the circulatory system.

Human Fms-Related Tyrosine Kinase 4 (FLT4) interaction partners

  1. The most extensively accepted signaling pathways promoting lymphangiogenesis in tumors include the secreted lymphangiogenic proteins: VEGF-C (show VEGFC Proteins) and VEGF-D (show Figf Proteins), and their cognate receptor on lymphatic endothelium VEGF receptor (show FLT1 Proteins)-3 (VEGFR-3).

  2. MTA1 (show MTA1 Proteins) is up-regulated in CRC (show CALR Proteins); its expression is inversely associated with lymphatic metastases and the expression of VEGFC (show VEGFC Proteins), VEGFD (show Figf Proteins) and VEGFR3

  3. this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8 (show LGALS8 Proteins)-dependent crosstalk among VEGF-C (show VEGFC Proteins), podoplanin (show PDPN Proteins) and integrin pathways plays a key role.

  4. Report FLT4 genetic alterations in angiosarcomas.

  5. High expression levels of VEGFR1 (show FLT1 Proteins) and VEGFR3 were associated with a higher rate of lung metastasis.

  6. Data indicate that foretinib suppresses angiogenesis and lymphangiogenesis by blocking vascular endothelial growth factor receptors

  7. Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis.

  8. A Novel Missense Mutation in FLT4 Causes Autosomal Recessive Hereditary Lymphedema

  9. our findings contribute to the putative targets in which the FLT4 gene mutation was found to have a significant role in lymphatic filariasis, while FOXC2 (show FOXC2 Proteins) and FLT4 SNP interactions need to be further elucidated at a functional level.

  10. Missense mutations in VEGFR3 confirmed Milroy disease in two unrelated patients.

Zebrafish Fms-Related Tyrosine Kinase 4 (FLT4) interaction partners

  1. Ca(2 (show CA2 Proteins)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (show CARD8 Proteins) vein, respectively.

  2. Experiments in mice and zebrafish demonstrate that changing levels of VEGFR3/Flt4 modulates aortic lumen diameter consistent with flow-dependent remodeling

  3. In the embryo, phenotypes driven by increased Vegfc (show VEGFC Proteins) are suppressed in the absence of Ccbe1 (show CCBE1 Proteins), and Vegfc (show VEGFC Proteins)-driven sprouting is enhanced by local Ccbe1 (show CCBE1 Proteins) overexpression. Moreover, Vegfc (show VEGFC Proteins)- and Vegfr3-dependent Erk (show MAPK1 Proteins) signaling is impaired in the absence of Ccbe1 (show CCBE1 Proteins).

  4. Flt4 plays an essential role in lymphangiogenesis [review]

  5. The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc (show VEGFC Proteins)/Vegfr3 signaling in zebrafish.

  6. Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.

  7. flt4 signalling is suppressed by Dll4 (show DLL4 Proteins) in developing zebrafish intersegmental arteries.

FLT4 Protein Profile

Protein Summary

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.

Alternative names and synonyms associated with FLT4

  • FMS-like tyrosine kinase 4 (Flt4)
  • fms-related tyrosine kinase 4 (FLT4)
  • fms-related tyrosine kinase 4 (Flt4)
  • fms-related tyrosine kinase 4 (flt4)
  • kinase insert domain protein receptor (Kdr)
  • 6130401C07 protein
  • AI323512 protein
  • cb1059 protein
  • Chy protein
  • Flk-1 protein
  • Flk1 protein
  • Flt-4 protein
  • FLT41 protein
  • Krd-1 protein
  • LMPH1A protein
  • Ly73 protein
  • PCL protein
  • sVEGFR-2 protein
  • VEGFR-2 protein
  • VEGFR-3 protein
  • VEGFR2 protein
  • Vegfr3 protein

Protein level used designations for FLT4

chylous ascites , receptor protein tyrosine kinase , tyrosine-protein kinase receptor FLT4 , vascular endothelial growth factor receptor 3 , vascular endothelial growth factor receptor-3 , FLT-4 , VEGFR-3 , fms-like tyrosine kinase 4 , soluble VEGFR3 variant 1 , soluble VEGFR3 variant 2 , soluble VEGFR3 variant 3 , FMS-like tyrosine kinase 4 , tyrosine kinase VEGFR-3 , VEGFR3 , expando , receptor tyrosine kinase Flt4 , VEGF receptor-2 , fetal liver kinase 1 , kinase NYK , protein-tyrosine kinase receptor flk-1 , soluble vascular endothelial growth factor receptor 2 , vascular endothelial growth factor receptor 2 , vascular endothelial growth factor receptor- 2 , vascular endothelial growth factor receptor-2

GENE ID SPECIES
14257 Mus musculus
2324 Homo sapiens
114110 Rattus norvegicus
338031 Bos taurus
100008829 Oryctolagus cuniculus
395742 Gallus gallus
30121 Danio rerio
16542 Mus musculus
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