Browse our FLT4 Proteins (FLT4)

Full name:
Fms-Related Tyrosine Kinase 4 Proteins (FLT4)
On are 37 Fms-Related Tyrosine Kinase 4 (FLT4) Proteins from 16 different suppliers available. Additionally we are shipping FLT4 Antibodies (277) and FLT4 Kits (48) and many more products for this protein. A total of 370 FLT4 products are currently listed.
6130401C07, AI323512, cb1059, Chy, Flk-1, Flk1, Flt-4, FLT41, Krd-1, LMPH1A, Ly73, PCL, sVEGFR-2, VEGFR-2, VEGFR-3, VEGFR2, Vegfr3
list all proteins Gene Name GeneID UniProt
FLT4 14257 P35917
FLT4 2324 P35916
FLT4 114110 Q91ZT1

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FLT4 Proteins (FLT4) by Origin

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Top referenced FLT4 Proteins

  1. Human FLT4 Protein expressed in Escherichia coli (E. coli) - ABIN2667606 : Cursiefen, Chen, Saint-Geniez, Hamrah, Jin, Rashid, Pytowski, Persaud, Wu, Streilein, Dana: Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 8 references for 2667606

  2. Mouse (Murine) FLT4 Protein expressed in Human Cells - ABIN2008007 : Pajusola, Aprelikova, Pelicci, Weich, Claesson-Welsh, Alitalo: Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors. in Oncogene 1994 (PubMed)
    Show all 5 references for 2008007

  3. Human FLT4 Protein expressed in Human Cells - ABIN2003421 : Tammela, Zarkada, Wallgard, Murtomäki, Suchting, Wirzenius, Waltari, Hellström, Schomber, Peltonen, Freitas, Duarte, Isoniemi, Laakkonen, Christofori, Ylä-Herttuala, Shibuya, Pytowski, Eichmann et al.: Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. ... in Nature 2008 (PubMed)
    Show all 5 references for 2003421

More Proteins for FLT4 Interaction Partners

Mouse (Murine) Fms-Related Tyrosine Kinase 4 (FLT4) interaction partners

  1. Endoglin (show ENG Proteins) prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 (show KDR Proteins) signalling

  2. CLEC14A (show CLEC14A Proteins) acts in vascular homeostasis by fine-tuning VEGFR-2 (show KDR Proteins) and VEGFR-3 signaling in endothelial cells

  3. The elevated soluble VEGFR-2 (show KDR Proteins) that was found in the aortas of apoE (show APOE Proteins)(-/-) mice with atherosclerosis binds to and diminishes the activity of VEGF-C (show VEGFC Proteins).

  4. Data show that Leishmania major infection initiates enhanced vascular endothelial growth factor-A (show VEGFA Proteins)/VEGFR-2 (show KDR Proteins) signaling and suggest that VEGFR-2 (show KDR Proteins)-dependent lymphangiogenesis is a mechanism that restricts tissue inflammation in leishmaniasis.

  5. VEGFR3 limits VEGFR2 (show KDR Proteins) expression and VEGF (show VEGFA Proteins)/VEGFR2 (show KDR Proteins) pathway activity in quiescent and angiogenic blood vascular endothelial cells, thereby preventing excessive vascular permeability.

  6. fetal mouse lung mesenchymal cells express Vegfr2 (show KDR Proteins) and respond to VEGF-A (show VEGFA Proteins) stimulation.

  7. Deletion of microRNA miR (show MLXIP Proteins)-150 increased the retinal pathological angiogenesis in high-fat-diet (HFD) induced type 2 diabetic mice, which was in part through vascular endothelial growth factor receptor 2 (VEGFR2 (show KDR Proteins)).

  8. findings demonstrated that a multi-component Chinese medicine DHI effectively increased blood flow recovery after tissue ischemia in diabetic mice by promoting angiogenesis and improving glucose tolerance through a concomitant activation of VEGF-A (show VEGFA Proteins)/VEGFR-2 (show KDR Proteins) and PPARdelta (show PPARD Proteins) signaling pathways

  9. Intronic Flk1 (show KDR Proteins) genetic enhancer element directs arterial-specific expression via RBPJ (show RBPJ Proteins)-mediated venous repression.

  10. Endothelial SCUBE2 may be a novel coreceptor for VEGFR2 and potentiate VEGF-induced signaling in adult angiogenesis.

Human Fms-Related Tyrosine Kinase 4 (FLT4) interaction partners

  1. Data show that VEGF-C (show VEGFC Proteins), VEGF-D (show Figf Proteins), and VEGFR-3 were expressed in a substantial percentage of breast carcinomas.

  2. There was a significant decrease in VEGFR3 expression in pulmonary arterial endothelial cells from pulmonary arterial hypertension patients.

  3. By treating LECs with VEGF (show VEGFA Proteins)-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early (show JUN Proteins)' transcription factors that showed a rapid transient upregulation VEGFR-3 stimulation. these results reveal an important and unanticipated role of HOXD10 (show HOXD10 Proteins) in the regulation of VEGFR-3 signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability.

  4. The normalized methylation values for the VEGFR1 (show FLT1 Proteins), VEGFR2 (show KDR Proteins) and VEGFR3 promoters tended to be higher in the tumour cell lines than in normal tonsil samples, whereas amounts of VEGFR1 (show FLT1 Proteins), VEGFR2 (show KDR Proteins) and VEGFR3 messenger RNA were significantly higher

  5. These results indicate that VEGF-C (show VEGFC Proteins)-induced MSC (show MSC Proteins) osteogenesis is mediated through VEGFR2 (show KDR Proteins) and VEGFR3, and followed the activation of the ERK (show EPHB2 Proteins)/RUNX2 (show RUNX2 Proteins) signaling pathway.

  6. Assessment of VEGFR-2/VEGFR (show KDR Proteins)-3 on tumor samples might serve as a putative prognostic factor in renal cell carcinoma (show MOK Proteins) cases, identifying a subset of patients that may benefit from antiangiogenic treatments targeting VEGFR (show KDR Proteins) receptors.

  7. This study suggests that NRP1 (show NELL1 Proteins) expression and LVD are independent factors that are likely to predict the risk of LN metastasis in squamous cell carcinoma (SCC (show CYP11A1 Proteins))of the tongue, whereas the expression of VEGFC (show VEGFC Proteins), VEGFR3, CCR7 (show CCR7 Proteins), and SEMA3E (show SEMA3E Proteins) are nonindependent predictive factors

  8. Data indicate that vascular endothelial growth factor D (VEGF-D (show Figf Proteins)) was the best indicator of metastasis and vascular endothelial growth factors and receptor-3 (VEGFR-3) may help to determine the prognosis and management of colorectal cancer (CRC (show CALR Proteins)).

  9. The summarizes the structure and function features of pathway-related molecules of VEGFC (show VEGFC Proteins)/D-VEGFR3/NRP2 (show NELL2 Proteins) axis, stages of various tumors and their molecular mechanisms and significances in tuthe expression changes of these molecules in different anatomic organs or histopathologic types or development lymphatic metastasis.

  10. The most extensively accepted signaling pathways promoting lymphangiogenesis in tumors include the secreted lymphangiogenic proteins: VEGF-C (show VEGFC Proteins) and VEGF-D (show Figf Proteins), and their cognate receptor on lymphatic endothelium VEGF receptor (show FLT1 Proteins)-3 (VEGFR-3).

Zebrafish Fms-Related Tyrosine Kinase 4 (FLT4) interaction partners

  1. miR (show MYLIP Proteins)-126a directs lymphatic endothelial cell sprouting and extension by interacting with Cxcl12a-mediated chemokine (show CCL1 Proteins) signaling and Vegfc (show VEGFC Proteins)-Flt4 signal axis.

  2. Ca(2 (show CA2 Proteins)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (show CARD8 Proteins) vein, respectively.

  3. Experiments in mice and zebrafish demonstrate that changing levels of VEGFR3/Flt4 modulates aortic lumen diameter consistent with flow-dependent remodeling

  4. In the embryo, phenotypes driven by increased Vegfc (show VEGFC Proteins) are suppressed in the absence of Ccbe1 (show CCBE1 Proteins), and Vegfc (show VEGFC Proteins)-driven sprouting is enhanced by local Ccbe1 (show CCBE1 Proteins) overexpression. Moreover, Vegfc (show VEGFC Proteins)- and Vegfr3-dependent Erk (show MAPK1 Proteins) signaling is impaired in the absence of Ccbe1 (show CCBE1 Proteins).

  5. Flt4 plays an essential role in lymphangiogenesis [review]

  6. The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc (show VEGFC Proteins)/Vegfr3 signaling in zebrafish.

  7. Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.

  8. flt4 signalling is suppressed by Dll4 (show DLL4 Proteins) in developing zebrafish intersegmental arteries.

FLT4 Protein Profile

Protein Summary

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.

Alternative names and synonyms associated with FLT4

  • FMS-like tyrosine kinase 4 (Flt4)
  • fms-related tyrosine kinase 4 (FLT4)
  • fms-related tyrosine kinase 4 (Flt4)
  • fms-related tyrosine kinase 4 (flt4)
  • kinase insert domain protein receptor (Kdr)
  • 6130401C07 protein
  • AI323512 protein
  • cb1059 protein
  • Chy protein
  • Flk-1 protein
  • Flk1 protein
  • Flt-4 protein
  • FLT41 protein
  • Krd-1 protein
  • LMPH1A protein
  • Ly73 protein
  • PCL protein
  • sVEGFR-2 protein
  • VEGFR-2 protein
  • VEGFR-3 protein
  • VEGFR2 protein
  • Vegfr3 protein

Protein level used designations for FLT4

chylous ascites , receptor protein tyrosine kinase , tyrosine-protein kinase receptor FLT4 , vascular endothelial growth factor receptor 3 , vascular endothelial growth factor receptor-3 , FLT-4 , VEGFR-3 , fms-like tyrosine kinase 4 , soluble VEGFR3 variant 1 , soluble VEGFR3 variant 2 , soluble VEGFR3 variant 3 , FMS-like tyrosine kinase 4 , tyrosine kinase VEGFR-3 , VEGFR3 , expando , receptor tyrosine kinase Flt4 , VEGF receptor-2 , fetal liver kinase 1 , kinase NYK , protein-tyrosine kinase receptor flk-1 , soluble vascular endothelial growth factor receptor 2 , vascular endothelial growth factor receptor 2 , vascular endothelial growth factor receptor- 2 , vascular endothelial growth factor receptor-2

14257 Mus musculus
2324 Homo sapiens
114110 Rattus norvegicus
338031 Bos taurus
100008829 Oryctolagus cuniculus
395742 Gallus gallus
30121 Danio rerio
16542 Mus musculus
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