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Browse our FLT4 Proteins (FLT4)

Full name:
Fms-Related Tyrosine Kinase 4 Proteins (FLT4)
On are 32 Fms-Related Tyrosine Kinase 4 (FLT4) Proteins from 14 different suppliers available. Additionally we are shipping FLT4 Antibodies (244) and FLT4 Kits (46) and many more products for this protein. A total of 330 FLT4 products are currently listed.
6130401C07, AI323512, cb1059, Chy, Flk-1, Flk1, Flt-4, FLT41, Krd-1, LMPH1A, Ly73, PCL, sVEGFR-2, VEGFR-2, VEGFR-3, VEGFR2, Vegfr3
list all proteins Gene Name GeneID UniProt
FLT4 14257 P35917
FLT4 2324 P35916
FLT4 114110 Q91ZT1

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FLT4 Proteins (FLT4) by Origin

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Top referenced FLT4 Proteins

  1. Human FLT4 Protein expressed in Escherichia coli (E. coli) - ABIN2667606 : Cursiefen, Chen, Saint-Geniez, Hamrah, Jin, Rashid, Pytowski, Persaud, Wu, Streilein, Dana: Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 8 references for ABIN2667606

  2. Mouse (Murine) FLT4 Protein expressed in Human Cells - ABIN2008007 : Pajusola, Aprelikova, Pelicci, Weich, Claesson-Welsh, Alitalo: Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors. in Oncogene 1994 (PubMed)
    Show all 5 references for ABIN2008007

  3. Human FLT4 Protein expressed in Human Cells - ABIN2003423 : Tammela, Zarkada, Wallgard, Murtomäki, Suchting, Wirzenius, Waltari, Hellström, Schomber, Peltonen, Freitas, Duarte, Isoniemi, Laakkonen, Christofori, Ylä-Herttuala, Shibuya, Pytowski, Eichmann et al.: Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. ... in Nature 2008 (PubMed)
    Show all 5 references for ABIN2003423

More Proteins for FLT4 Interaction Partners

Mouse (Murine) Fms-Related Tyrosine Kinase 4 (FLT4) interaction partners

  1. findings demonstrated that a multi-component Chinese medicine DHI effectively increased blood flow recovery after tissue ischemia in diabetic mice by promoting angiogenesis and improving glucose tolerance through a concomitant activation of VEGF-A (show VEGFA Proteins)/VEGFR-2 (show KDR Proteins) and PPARdelta (show PPARD Proteins) signaling pathways

  2. Intronic Flk1 (show KDR Proteins) genetic enhancer element directs arterial-specific expression via RBPJ (show RBPJ Proteins)-mediated venous repression.

  3. Endothelial SCUBE2 may be a novel coreceptor for VEGFR2 and potentiate VEGF-induced signaling in adult angiogenesis.

  4. VEGFR2 (show KDR Proteins) signaling is necessary to maintain the integrity of the intestinal mucosal microvasculature during the postnatal period and lack of VEGFR2 (show KDR Proteins) signaling predisposes to NEC in neonatal mice.

  5. First-in-class selective PET tracers for imaging VEGFR-1 (show FLT1 Proteins) and VEGFR-2 (show KDR Proteins) were constructed and successfully validated in an orthotopic murine tumor model.

  6. Blockade of FLT4 suppresses metastasis of melanoma cells by impaired lymphatic vessels.

  7. Vegf-d (show Figf Proteins) and its receptor Vegfr-3 were more highly expressed in lungs of hyperoxic, versus normoxic, wild-type mice, indicating that components of the Vegf-d (show Figf Proteins) signalling pathway are up-regulated in hyperoxia.

  8. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

  9. We found that bevacizumab reduced airway hyper-responsiveness (AHR (show AHR Proteins)) and airway inflammation induced by HDM (show HDAC3 Proteins). In addition, HDM (show HDAC3 Proteins) exposure promoted expression of VEGF (show VEGFA Proteins), and caused AHR (show AHR Proteins), disruptions of the epithelial barrier, and airway inflammation. Bevacizumab ameliorated AHR (show AHR Proteins) and the release of Th2 cytokines, thereby protecting the epithelial barrier. Our data suggest that bevacizumab may be a new therapeutic strategy for asthm

  10. Introduction of sVEGFR-2 suppressed lymphangiogenesis in primary lung cancer and also suppressed lymphogenic metastasis by inhibiting VEGF-C (show VEGFC Proteins), followed by down-regulation of VEGFR-2 (show KDR Proteins), VEGFR-3 and MMPs.

Human Fms-Related Tyrosine Kinase 4 (FLT4) interaction partners

  1. These results indicate that VEGF-C (show VEGFC Proteins)-induced MSC (show MSC Proteins) osteogenesis is mediated through VEGFR2 (show KDR Proteins) and VEGFR3, and followed the activation of the ERK (show EPHB2 Proteins)/RUNX2 (show RUNX2 Proteins) signaling pathway.

  2. Assessment of VEGFR-2/VEGFR (show KDR Proteins)-3 on tumor samples might serve as a putative prognostic factor in renal cell carcinoma (show MOK Proteins) cases, identifying a subset of patients that may benefit from antiangiogenic treatments targeting VEGFR (show KDR Proteins) receptors.

  3. This study suggests that NRP1 (show NELL1 Proteins) expression and LVD are independent factors that are likely to predict the risk of LN metastasis in squamous cell carcinoma (SCC (show CYP11A1 Proteins))of the tongue, whereas the expression of VEGFC (show VEGFC Proteins), VEGFR3, CCR7 (show CCR7 Proteins), and SEMA3E (show SEMA3E Proteins) are nonindependent predictive factors

  4. Data indicate that vascular endothelial growth factor D (VEGF-D (show Figf Proteins)) was the best indicator of metastasis and vascular endothelial growth factors and receptor-3 (VEGFR-3) may help to determine the prognosis and management of colorectal cancer (CRC (show CALR Proteins)).

  5. The summarizes the structure and function features of pathway-related molecules of VEGFC (show VEGFC Proteins)/D-VEGFR3/NRP2 (show NELL2 Proteins) axis, stages of various tumors and their molecular mechanisms and significances in tuthe expression changes of these molecules in different anatomic organs or histopathologic types or development lymphatic metastasis.

  6. The most extensively accepted signaling pathways promoting lymphangiogenesis in tumors include the secreted lymphangiogenic proteins: VEGF-C (show VEGFC Proteins) and VEGF-D (show Figf Proteins), and their cognate receptor on lymphatic endothelium VEGF receptor (show FLT1 Proteins)-3 (VEGFR-3).

  7. MTA1 (show MTA1 Proteins) is up-regulated in CRC (show CALR Proteins); its expression is inversely associated with lymphatic metastases and the expression of VEGFC (show VEGFC Proteins), VEGFD (show Figf Proteins) and VEGFR3

  8. this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8 (show LGALS8 Proteins)-dependent crosstalk among VEGF-C (show VEGFC Proteins), podoplanin (show PDPN Proteins) and integrin pathways plays a key role.

  9. Report FLT4 genetic alterations in angiosarcomas.

  10. High expression levels of VEGFR1 (show FLT1 Proteins) and VEGFR3 were associated with a higher rate of lung metastasis.

Zebrafish Fms-Related Tyrosine Kinase 4 (FLT4) interaction partners

  1. miR (show MYLIP Proteins)-126a directs lymphatic endothelial cell sprouting and extension by interacting with Cxcl12a-mediated chemokine (show CCL1 Proteins) signaling and Vegfc (show VEGFC Proteins)-Flt4 signal axis.

  2. Ca(2 (show CA2 Proteins)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (show CARD8 Proteins) vein, respectively.

  3. Experiments in mice and zebrafish demonstrate that changing levels of VEGFR3/Flt4 modulates aortic lumen diameter consistent with flow-dependent remodeling

  4. In the embryo, phenotypes driven by increased Vegfc (show VEGFC Proteins) are suppressed in the absence of Ccbe1 (show CCBE1 Proteins), and Vegfc (show VEGFC Proteins)-driven sprouting is enhanced by local Ccbe1 (show CCBE1 Proteins) overexpression. Moreover, Vegfc (show VEGFC Proteins)- and Vegfr3-dependent Erk (show MAPK1 Proteins) signaling is impaired in the absence of Ccbe1 (show CCBE1 Proteins).

  5. Flt4 plays an essential role in lymphangiogenesis [review]

  6. The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc (show VEGFC Proteins)/Vegfr3 signaling in zebrafish.

  7. Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.

  8. flt4 signalling is suppressed by Dll4 (show DLL4 Proteins) in developing zebrafish intersegmental arteries.

FLT4 Protein Profile

Protein Summary

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.

Alternative names and synonyms associated with FLT4

  • FMS-like tyrosine kinase 4 (Flt4)
  • fms-related tyrosine kinase 4 (FLT4)
  • fms-related tyrosine kinase 4 (Flt4)
  • fms-related tyrosine kinase 4 (flt4)
  • kinase insert domain protein receptor (Kdr)
  • 6130401C07 protein
  • AI323512 protein
  • cb1059 protein
  • Chy protein
  • Flk-1 protein
  • Flk1 protein
  • Flt-4 protein
  • FLT41 protein
  • Krd-1 protein
  • LMPH1A protein
  • Ly73 protein
  • PCL protein
  • sVEGFR-2 protein
  • VEGFR-2 protein
  • VEGFR-3 protein
  • VEGFR2 protein
  • Vegfr3 protein

Protein level used designations for FLT4

chylous ascites , receptor protein tyrosine kinase , tyrosine-protein kinase receptor FLT4 , vascular endothelial growth factor receptor 3 , vascular endothelial growth factor receptor-3 , FLT-4 , VEGFR-3 , fms-like tyrosine kinase 4 , soluble VEGFR3 variant 1 , soluble VEGFR3 variant 2 , soluble VEGFR3 variant 3 , FMS-like tyrosine kinase 4 , tyrosine kinase VEGFR-3 , VEGFR3 , expando , receptor tyrosine kinase Flt4 , VEGF receptor-2 , fetal liver kinase 1 , kinase NYK , protein-tyrosine kinase receptor flk-1 , soluble vascular endothelial growth factor receptor 2 , vascular endothelial growth factor receptor 2 , vascular endothelial growth factor receptor- 2 , vascular endothelial growth factor receptor-2

14257 Mus musculus
2324 Homo sapiens
114110 Rattus norvegicus
338031 Bos taurus
100008829 Oryctolagus cuniculus
395742 Gallus gallus
30121 Danio rerio
16542 Mus musculus
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