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Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 (show GAB2 Antibodies) is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 (show GAB2 Antibodies) are recruited to Il4r (show IL4R Antibodies), synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 (show GAB2 Antibodies) = growth factor receptor bound protein 2-associated protein 2 (show GAB2 Antibodies); Il4r (show IL4R Antibodies) = interleukin-4 receptor (show IL4R Antibodies))
these findings suggest that the striated (show NSDHL Antibodies) muscle-specific (show EIF3K Antibodies) high-MW isoform of Gab1 has a crucial role for NRG-1 (show NRG1 Antibodies)/ErbB (show EGFR Antibodies) signaling in cardiomyocytes.
These findings provide the direct evidence about the roles of docking protein Gab1 in lungs.
These results demonstrate that cardiomyocyte Gab1 is a critical regulator of the compensatory cardiac response to aging and hemodynamic stress.
Gab1 is essential regulator of the hair cycle and the self-renewal of hair follicle stem cells.
Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.
Hepatocyte Gab1 is required for liver fibrosis and that hepatocyte CCL5 (show CCL5 Antibodies) could be an important contributor to this process.
endothelial Gab1 signaling inhibited splenomegaly in portal hypertension independent of angiogenesis.
Suggest that Gab1 is essential for cardioprotection against ischemia reperfusion oxidative injury, mediating survival signaling.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
Knockdown of GAB1 mimicked the tumor-suppressive effects of miR (show MLXIP Antibodies)-150 overexpression on HCC (show FAM126A Antibodies) cells, whereas restoration of GAB1 expression partially abolished the inhibitory effects.
The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 (show GAB2 Antibodies) and their complexes with Shp2 (show PTPN11 Antibodies). VEGFR2 (show KDR Antibodies) recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2 (show GAB2 Antibodies). As Gab2 (show GAB2 Antibodies) binds VEGFR2 (show KDR Antibodies) complexes more transiently than Gab1, VEGFR2 (show KDR Antibodies) complexes can recycle and continue to participate in other signaling pathways.
data suggested that miR (show MLXIP Antibodies)-141-3p decreased the proliferation and migration of keloid fibroblasts by repressing GAB1 expression, providing a useful target for keloid management
Gab1 expression is correlated with poor prognosis of Epithelial ovarian cancer patients.
these data provide novel information for comprehending the tumor-suppressive role of miR (show MLXIP Antibodies)-200a in HCC (show FAM126A Antibodies) pathogenesis through inhibition of GAB1 translation.
Gab1 has a role in regulating SDF-1 (show CXCL12 Antibodies)-induced progression via inhibition of apoptosis pathway induced by PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies)/Bcl-2 (show BCL2 Antibodies)/BAX (show BAX Antibodies) pathway in human chondrosarcoma (CS). Gab1 can be recommended as a novel biomarker for diagnosis and prognosis in patients with CS.
We found that expression of Gab1, VEGFR-2 (show KDR Antibodies), and MMP-9 (show MMP9 Antibodies) was highly and positively correlated with each other and with lymph node metastasis and TNM (show ODZ1 Antibodies) stage in intrahepatic cholangiocarcinoma tissues
Gab1 protein was upregulated in cyanotic compared to acyanotic hearts suggesting that Gab1 upregulation is a component of the survival program initiated by hypoxia in cyanotic children
CVB3 targets host GAB1 to generate a GAB1-N1-174 fragment that enhances viral infectivity, at least in part, via activation of the ERK (show EPHB2 Antibodies) pathway
These data suggest that Gab1-ERK1/2 (show MAPK1/3 Antibodies) binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Antibodies) nuclear accumulation.
Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B (show AKT1 Antibodies) and endothelial nitric-oxide synthase (show NOS3 Antibodies) activation in endothelial cells
Gab1 is a novel critical regulatory component of endothelial cell migration and capillary formation with a key role in the activation of VEGF-evoked signaling pathways required for angiogenesis
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
GRB2-associated binder 1
, GRB2-associated-binding protein 1
, GRB2-associated binding protein 1 long isoform
, growth factor receptor bound protein 2-associated protein 1