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These results demonstrate that cardiomyocyte Gab1 is a critical regulator of the compensatory cardiac response to aging and hemodynamic stress.
Gab1 is essential regulator of the hair cycle and the self-renewal of hair follicle stem cells.
Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.
Hepatocyte Gab1 is required for liver fibrosis and that hepatocyte CCL5 (show CCL5 Antibodies) could be an important contributor to this process.
endothelial Gab1 signaling inhibited splenomegaly in portal hypertension independent of angiogenesis.
Suggest that Gab1 is essential for cardioprotection against ischemia reperfusion oxidative injury, mediating survival signaling.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
the acquired substrate preference for GAB1 is critical for the ERBB2 (show ERBB2 Antibodies) mutant-induced oncogenesis.
endothelial Gab1 deletion accelerates AngII-dependent vascular inflammation and atherosclerosis on ApoE (show APOE Antibodies)-null background presumably in association with downregulation of KLF2 (show KLF2 Antibodies) and KLF4 (show KLF4 Antibodies).
The scaffolding adaptor GAB1 interacts with two polarity proteins, PAR1 (show F2R Antibodies) and PAR3 (show F2RL2 Antibodies).
Gab1 has a role in regulating SDF-1 (show CXCL12 Antibodies)-induced progression via inhibition of apoptosis pathway induced by PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies)/Bcl-2 (show BCL2 Antibodies)/BAX (show BAX Antibodies) pathway in human chondrosarcoma (CS). Gab1 can be recommended as a novel biomarker for diagnosis and prognosis in patients with CS.
We found that expression of Gab1, VEGFR-2 (show KDR Antibodies), and MMP-9 (show MMP9 Antibodies) was highly and positively correlated with each other and with lymph node metastasis and TNM (show ODZ1 Antibodies) stage in intrahepatic cholangiocarcinoma tissues
Gab1 protein was upregulated in cyanotic compared to acyanotic hearts suggesting that Gab1 upregulation is a component of the survival program initiated by hypoxia in cyanotic children
CVB3 targets host GAB1 to generate a GAB1-N1-174 fragment that enhances viral infectivity, at least in part, via activation of the ERK (show EPHB2 Antibodies) pathway
EGFR (show EGFR Antibodies)-activated Src (show SRC Antibodies) family kinases maintain GAB1-SHP2 (show PTPN11 Antibodies) complexes distal from EGFR (show EGFR Antibodies).
Data demonstrate that miR (show MLXIP Antibodies)-409-3p is a metastatic suppressor, and post-transcriptional inhibition of the oncoprotein GAB1 is one of its mechanisms of action.
Results suggest that Gab1 is an essential regulator of the EGF (show EGF Antibodies)-mediated mTORC pathways and may potentially be used as a biomarker for urothelial carcinoma
Studied the pleckstrin (show PLEK Antibodies) homology (PH) domain of GAB1 for cancer treatment. Using homology models we derived, high-throughput virtual screening of five million compounds resulted in five hits which exhibited strong binding affinities to GAB1 PH domain.
C-SH3 of Grb2 (show GRB2 Antibodies) mediates the interaction with mutant Htt (show HTT Antibodies) and this interaction being stronger could replace Gab1, with mutant Htt (show HTT Antibodies) becoming the preferred partner. This would have immense effect on downstream signaling events.
These data suggest that Gab1-ERK1/2 (show MAPK1/3 Antibodies) binding and their nuclear translocation play a crucial role in Egr-1 (show EGR1 Antibodies) nuclear accumulation.
Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B (show AKT1 Antibodies) and endothelial nitric-oxide synthase (show NOS3 Antibodies) activation in endothelial cells
Gab1 is a novel critical regulatory component of endothelial cell migration and capillary formation with a key role in the activation of VEGF-evoked signaling pathways required for angiogenesis
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
GRB2-associated binder 1
, GRB2-associated-binding protein 1
, GRB2-associated binding protein 1 long isoform
, growth factor receptor bound protein 2-associated protein 1