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GAB1 antibody
GAB1
Reactivity: Human
WB
Host: Mouse
Monoclonal
1AT1979
unconjugated
Product Details anti-GAB1 Antibody
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Target
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GAB1
(GRB2-Associated Binding Protein 1 (GAB1))
Reactivity
All reactivities for GAB1 antibodies
Human
Host
All hosts for GAB1 antibodies
Mouse
Clonality
All clonalities for GAB1 antibodies
Monoclonal
Conjugate
All conjugates for GAB1 antibodies
This GAB1 antibody is un-conjugated
Application
All applications for GAB1 antibodies
Western Blotting (WB)
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Immunogen
This Gab1 antibody is generated from mice immunized with a GST fusion protein encoding full length human GAB1.
Clone
1AT1979
Isotype
IgG1
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Discover our top product GAB1 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB: 1:1000. WB: 1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
References for anti-GAB1 antibody (ABIN6243205)
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Fan, Wong, Marino, Ou, Shen, Wu, Wong, Reiser, Johnson : "Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants. " in: The Journal of biological chemistry , Vol. 288 , Issue 23 , pp. 16895-904 , (2013 ) (PubMed ).
Sun, Yuan, Liu, Shi, Baker, Vuori, Wu, Feng : "Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis. " in: Molecular and cellular biology , Vol. 24 , Issue 4 , pp. 1531-9 , (2004 ) (PubMed ).
Target Details for GAB1
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Target
GAB1
(GRB2-Associated Binding Protein 1 (GAB1))
Alternative Name
Gab1 (GAB1 Products )
Synonyms
AA408973 antibody, AW107238 antibody, growth factor receptor bound protein 2-associated protein 1 antibody, GRB2-associated binding protein 1 antibody, GRB2 associated binding protein 1 antibody, Gab1 antibody, GAB1 antibody
Background
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
Molecular Weight
76616
NCBI Accession
NP_002030 , NP_997006
UniProt
Q13480
Pathways
RTK Signaling , Signaling Events mediated by VEGFR1 and VEGFR2 , Platelet-derived growth Factor Receptor Signaling , Signaling of Hepatocyte Growth Factor Receptor , VEGFR1 Specific Signals
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