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anti-Human IGF1R Antibodies:
anti-Rat (Rattus) IGF1R Antibodies:
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Human Polyclonal IGF1R Primary Antibody for IHC, WB - ABIN363154
Counillon, Pouysségur: The expanding family of eucaryotic Na(+)/H(+) exchangers. in The Journal of biological chemistry 2000
Show all 5 references for ABIN363154
Human Polyclonal IGF1R Primary Antibody for IHC, WB - ABIN363153
OConnor, Kauffmann-Zeh, Liu, Lehar, Evan, Baserga, Blättler: Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. in Molecular and cellular biology 1997
Show all 5 references for ABIN363153
Human Polyclonal IGF1R Primary Antibody for WB - ABIN871427
Adams, Epa, Garrett, Ward: Structure and function of the type 1 insulin-like growth factor receptor. in Cellular and molecular life sciences : CMLS 2000
Show all 4 references for ABIN871427
Human Polyclonal IGF1R Primary Antibody for WB - ABIN362638
Li, Ferber, Miura, Baserga: Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain. in The Journal of biological chemistry 1995
Show all 3 references for ABIN362638
Human Polyclonal IGF1R Primary Antibody for IF, WB - ABIN362040
Han, Quirion, Zheng: WITHDRAWN: Glutamate Attenuates IGF-1 Receptor Signaling via NR2B containing NMDA Receptors 3 and neuronal Nitric Oxide Synthase. in Biochemical and biophysical research communications 2011
Show all 2 references for ABIN362040
Human Polyclonal IGF1R Primary Antibody for IF, IHC - ABIN362636
Yamamoto, Oshima, Yoshihara, Nishi, Arai, Inui, Kaneko, Nozawa, Adachi, Rino, Masuda, Imada: Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer. in Experimental and therapeutic medicine 2012
Show all 2 references for ABIN362636
miR223 may regulate the acquired resistance of PC9 (show PCSK9 Antibodies)/ER cells to erlotinib by targeting the IGF-1R/Akt (show AKT1 Antibodies)/S6 signaling pathway.
decreasing IGF-1R mRNA and protein expression in NCI H295R cells can partially inhibit adrenal tumor cell growth in vitro.
High IGF1R expression is associated with gastric cancer.
IGF2R (show IGF2R Antibodies) plays a minor role in regulating the activity of IGF1R under a variety of conditions and that due to their high expression levels, IGFBPs are the dominant mechanism to regulating IGF network activation
methylation of IGF-1 (show IGF1 Antibodies), IGF1R, IGFBP3 (show IGFBP3 Antibodies), and IGF-1 (show IGF1 Antibodies) + IGF1R + IGFBP3 (show IGFBP3 Antibodies) was closely linked with the occurrence of EC and patients' clinicopathological features. Besides, the methylation status of the target genes and the expressions of IGF-1 (show IGF1 Antibodies) and IGF-1R protein were independent factors of EC prognosis, which could provide a direction for the prognosis and treatment of EC.
Positive correlations indicated probable cross-talk between the IGF-IR-mediated and adiponectin (show ADIPOQ Antibodies)-mediated signaling pathways.
IGF1R is a direct target of miR (show MLXIP Antibodies)-494 in epithelial ovarian carcinoma cells. miR (show MLXIP Antibodies)-494 overexpression inhibited IGF1R expression and its downstream signal protein (show KLK7 Antibodies) expression. IGF1R downregulation has similar effects to miR (show MLXIP Antibodies)-494 overexpression on EOC cells, and overexpression of IGF1R effectively rescued the inhibition of overexpressed miR (show MLXIP Antibodies)-494 in EOC cells. miR (show MLXIP Antibodies)-494 directly binds the IGF1R 3'-UTR (show UTS2R Antibodies).
identification of IGF-1R in odontogenic myxoma is shared with numerous tumours and indicates the ability of these tumour cells to respond to growth factors
NANOG (show NANOG Antibodies) was regulated by extracellular IGF signaling pathway via STAT3 (show STAT3 Antibodies) phosphorylation in colorectal cancer (CRC (show CALR Antibodies)). This coincides with that IGF receptor IGF-1R is often increasing expressed in malignant metastasis colon cancer. Taken together, our data define the crucial functions of IGF/STAT3 (show STAT3 Antibodies)/NANOG (show NANOG Antibodies)/Slug (show SNAI2 Antibodies) signaling axis in the progression of CRC (show CALR Antibodies)
This study suggests IGF1R as a potential biomarker of improved clinical outcome in HR+ve breast cancer patients treated with exemestane. Adding metformin to exemestane treatment may add to this effect
Suggest that overexpression of IGF-IR or IRA (show INSR Antibodies) isoform, as homodimers or as part of IRA (show INSR Antibodies)/IGF-IR hybrid receptors, confers a stronger migratory capability to vascular smooth muscle cells and might occur in early stages of atherosclerotic process.
Macrophage IGF1R signaling suppresses macrophage and foam cell accumulation in lesions and reduces plaque vulnerability, providing a novel mechanism whereby IGF-1 (show IGF1 Antibodies) exerts antiatherogenic effects in ApoE (show APOE Antibodies) knockout mice.
study recognized the promotion of miR (show MLXIP Antibodies)-223 level by AGE-BSA treatment in osteoblast-like MC3T3-E1 cells. The promoted miR (show MLXIP Antibodies)-223 targeted IGF-1R and mediated the AGE-BSA-induced apoptosis in MC3T3-E1 cells.
osterix (show SP7 Antibodies) is a downstream target of IGF1R in chondrocytes.
NF-kappaB (show NFKB1 Antibodies)-miR (show MLXIP Antibodies)-195/497-Igf1r/Insr (show INSR Antibodies)-Ccnd2 (show CCND2 Antibodies)/Ccne1 (show CCNE1 Antibodies) plays important roles in myogenesis.
this study, we have characterized epigenetic changes following pregnancy and found that Igf1r and other IGF family members are hypermethylated and downregulated.
IGF1R signaling was necessary for DC-mediated T-ALL survival.
mitochondria, activated by IGF-1R signaling, constitute a critical regulator of information processing in hippocampal neurons.
IGF1R is involved in osteoblast differentiation during fracture repair and it plays an important role in coordinating chondrocyte, osteoclast, and endothelial responses that contribute to endochondral bone formation required for normal fracture repair
ectopic down-regulation of IGF1R reversed the protective effect of miR (show MLXIP Antibodies)-100 down-regulation on H2O2-induced apoptosis, revealing that miR (show MLXIP Antibodies)-100 regulates cardiomyocyte apoptosis through the association of IGF1R.
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
insulin-like growth factor I receptor
, IGF-I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor 1 receptor
, line 186