Browse our IGF1R Proteins (IGF1R)

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Insulin-Like Growth Factor 1 Receptor Proteins (IGF1R)
On are 42 Insulin-Like Growth Factor 1 Receptor (IGF1R) Proteins from 14 different suppliers available. Additionally we are shipping IGF1R Antibodies (487) and IGF1R Kits (53) and many more products for this protein. A total of 598 IGF1R products are currently listed.
A330103N21Rik, CD221, D930020L01, DKFZp469I0618, hyft, igf-1r, igf-ir, IGF1R, IGFIR, IGFIRC, IGFR, IGFR1, JTK13, xIGF-1R, xigf1r, xIGFR
list all proteins Gene Name GeneID UniProt
IGF1R 3480 P08069
IGF1R 25718 P24062
IGF1R 16001 Q60751

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IGF1R Proteins (IGF1R) by Origin

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Top referenced IGF1R Proteins

  1. Human IGF1R Protein expressed in Human Cells - ABIN2002215 : Tollefsen, Stoszek, Thompson: Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation. in Biochemistry 1991 (PubMed)
    Show all 5 references for 2002215

More Proteins for IGF1R Interaction Partners

Horse (Equine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. This study evaluated the expression of IGF-1 (show IGF1 Proteins) receptor, insulin receptor (show INSR Proteins) AND IGF-1 (show IGF1 Proteins) in the lammelar tissue of horses with insulin (show INS Proteins)-induced hyperinsulinemia.

  2. The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.

  3. Somatomedin (IGF-I (show IGF1 Proteins)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]

Human Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. Results provide evidence that cathepsin G (show CTSG Proteins) (GC) activates IGF-1R by stimulating IGF-1 (show IGF1 Proteins) release from MCF-7 cells, and that IGF-1R activation is required for CG-induced cell aggregation.

  2. GRK2 (show ADRBK1 Proteins) is negatively related to IGF1R and IGF1R, but not GRK2 (show ADRBK1 Proteins), was associated with the tumour-node-metastasis stage and overall and disease-free survival in hepatocellular carcinoma.

  3. Heterodimerization of EGFR (show EGFR Proteins) with IGF-1R can lead to increased activity of EGFR (show EGFR Proteins) and may be an important platform for cetuximab mediated signaling in head and neck tumors that have become resistant to anti-EGFR (show EGFR Proteins) therapy.

  4. mTORC1/2 inhibition promotes reorganization of integrin/focal adhesion kinase-mediated adhesomes, induction of IGFR/IR-dependent PI3K (show PIK3CA Proteins) activation, and Akt (show AKT1 Proteins) phosphorylation via an integrin/FAK (show PTK2 Proteins)/IGF1R-dependent process, mediating tumor drug resistance.

  5. We found that the thyroid hormone receptor (show THRA Proteins) (TRalpha (show THRA Proteins) 3) has a differential expression profile. Thyroid hormone (show PTH Proteins) is critical for normal brain development. Our results showed that there is a possible link between IGF1 (show IGF1 Proteins)/IGF1R and the TRalpha (show THRA Proteins) 3 and that over expression of IGF1R in RTT cells may be the cause of neurites improvement in neural RTT-derived neurons.

  6. Data show that the let-7c/miR (show MLXIP Proteins)-99a/miR (show MLXIP Proteins)-125b cluster controlled tumorigenesis by targeting IL-6 (show IL6 Proteins), IL-6R and IGF1R.

  7. IGF1R expression may have prognostic relevance in penile squamous cell carcinoma

  8. High IGF1R expression is associated with bone metastasis in prostate cancer.

  9. the Runx2 (show RUNX2 Proteins) knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha (show GRK4 Proteins)), the sensor of cellular metabolism. Importantly, the Runx2 (show RUNX2 Proteins) knockdown in bone-derived cells resulted in increased sensitivity to both Erk1/2 inhibition and AMPKalpha (show GRK4 Proteins) activation by PD184161 and metformin, respectively, despite increased IGF-1Rbeta and AMPKalpha (show GRK4 Proteins) levels.

  10. Overexpression of mutated K-RAS in gastrointestinal cancer cell lines led to more aggressive phenotypes, with increased proliferation, decreased apoptosis, and increased motility and invasion. IGF-1R blockade suppressed cell growth, colony formation, migration, and invasion, and up-regulated chemotherapy-induced apoptosis of gastrointestinal cancer cells, even when mutated K-RAS was over-expressed.

Pig (Porcine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. IGF-I (show IGF1 Proteins), IGF-II, and IGFBP-3 (show IGFBP3 Proteins) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.

  2. IL-1beta (show IL1B Proteins) impaired the actions of IGF-I (show IGF1 Proteins) at a point distal to the IGF receptor

  3. IGF-1R is expressed in porcine somatostatin (show SST Proteins)-containing islet D-cells

  4. This study suggests an association between the affinity of insulin (show INS Proteins) receptors and number of IGF-1 (show IGF1 Proteins) receptors with placental and/or fetal growth.

  5. mRNA expression of IGF-I receptor

Cow (Bovine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.

  2. study determined IGFR1 and PAPP-A (show PAPPA Proteins) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Proteins)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (show PAPPA Proteins) secretion as a modulator of IGF1 (show IGF1 Proteins) in cattle with COD (show SNRPB Proteins)

  3. Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.

  4. two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle

  5. insulin (show INS Proteins)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization

  6. The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.

  7. Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 Proteins), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.

  8. Results do not support the premise that increased apoptosis associated with high levels of IGF1 (show IGF1 Proteins) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.

  9. IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR (show FRAP1 Proteins) activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.

  10. IGF-1 (show IGF1 Proteins) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.

Mouse (Murine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. IGF1R has a crucial role in granulosa cells function and, consequently, in female fertility.

  2. Ubiquitous inducible IGF-1R knockout (UBIKOR) mice were strikingly lean with coordinate changes in body composition and organ size. They were insulin (show INS Proteins) resistant but preserved physiological energy expenditure and displayed enhanced fasting metabolic flexibility.

  3. the overlap of IR and IGF1R signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (show FOXO3 Proteins)-regulated, autophagy-mediated protein degradation

  4. SUMOylation of IGF1R affects upstream mechanisms that control and coordinate expression of cell cycle regulators to increase cell cycle progression and proliferation.

  5. findings demonstrated that significant resistance of the brain to amyloid-beta can be achieved lifelong by suppressing neuronal IGF1R.

  6. Results found that glioblastoma tumors resistant to PDGFR (show PDGFRB Proteins) inhibition required the expression and activation of the insulin receptor (IR (show INSR Proteins))/insulin (show INS Proteins) growth-like factor receptor (IGF1R) for tumor cell proliferation and survival.

  7. Conditional deletion of synaptotagmin-10, the Ca(2 (show CA2 Proteins)+) sensor for IGF1 (show IGF1 Proteins) secretion from mitral cells, or deletion of IGF1 (show IGF1 Proteins) receptor in the olfactory bulb prevented the socially relevant GABAergic long-term potentiation and impaired memory formation after social transmission of food preference.

  8. These results support the role of Igf1r in controlling the kinetics of cell proliferation and differentiation during pulmonary airway epithelial regeneration after injury.

  9. Although smaller than WT (wild type) mice, old-aged Igf1r(+/-) had increased adiposity and exhibit increased lipogenesis. We hypothesize that IGF-1 (show IGF1 Proteins) resistance initially causes a transient increase in insulin (show INS Proteins) signaling thereby promoting a lipogenic phenotype, which subsequently leads to insulin (show INS Proteins) resistance.

  10. HASF is a novel ligand of IGF1R.

IGF1R Protein Profile

Protein Summary

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Alternative names and synonyms associated with IGF1R

  • insulin-like growth factor 1 receptor (IGF1R)
  • insulin-like growth factor 1 receptor (Igf1r)
  • insulin-like growth factor 1 receptor (igf1r)
  • insulin-like growth factor I receptor (Igf1r)
  • insulin-like growth factor I receptor (LOC780503)
  • insulin-like growth factor I receptor (igf-ir)
  • A330103N21Rik protein
  • CD221 protein
  • D930020L01 protein
  • DKFZp469I0618 protein
  • hyft protein
  • igf-1r protein
  • igf-ir protein
  • IGF1R protein
  • IGFIR protein
  • IGFIRC protein
  • IGFR protein
  • IGFR1 protein
  • JTK13 protein
  • xIGF-1R protein
  • xigf1r protein
  • xIGFR protein

Protein level used designations for IGF1R

IGF-I receptor , insulin-like growth factor I receptor , soluble IGF1R variant 1 , soluble IGF1R variant 2 , insulin-like growth factor receptor tyrosine kinase , insulin-like growth factor-I receptor , type 1 IGF receptor , tyrosine kinase , IGF-1 receptor , insulin-like growth factor 1 receptor beta subunit , insulin-like growth factor receptor 1 , insulin-like growth factor-1 receptor , receptor tyrosine kinase , insulin-like growth factor 1 receptor , line 186 , insulin-like growth factor-1 receptor beta subunit , xIGF-1R , xIGFR

3480 Homo sapiens
25718 Rattus norvegicus
281848 Bos taurus
395889 Gallus gallus
397350 Sus scrofa
442951 Canis lupus familiaris
453676 Pan troglodytes
100172156 Pongo abelii
100329112 Xenopus (Silurana) tropicalis
16001 Mus musculus
100020095 Monodelphis domestica
780503 Ovis aries
100136427 Salmo salar
398022 Xenopus laevis
100055698 Equus caballus
100734840 Cavia porcellus
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