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Browse our IGF1R Proteins (IGF1R)

Full name:
Insulin-Like Growth Factor 1 Receptor Proteins (IGF1R)
On are 32 Insulin-Like Growth Factor 1 Receptor (IGF1R) Proteins from 14 different suppliers available. Additionally we are shipping IGF1R Antibodies (433) and IGF1R Kits (37) and many more products for this protein. A total of 518 IGF1R products are currently listed.
A330103N21Rik, CD221, D930020L01, DKFZp469I0618, hyft, IGF-1R, IGF1R, IGFIR, IGFIRC, IGFR, IGFR1, JTK13, xIGF-1R, xigf1r, xIGFR
list all proteins Gene Name GeneID UniProt
IGF1R 3480 P08069
IGF1R 25718 P24062
IGF1R 16001 Q60751

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IGF1R Proteins (IGF1R) by Origin

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Top referenced IGF1R Proteins

  1. Human IGF1R Protein expressed in Human Cells - ABIN2002215 : Tollefsen, Stoszek, Thompson: Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation. in Biochemistry 1991 (PubMed)
    Show all 5 references for ABIN2002215

More Proteins for IGF1R Interaction Partners

Horse (Equine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. This study evaluated the expression of IGF-1 (show IGF1 Proteins) receptor, insulin receptor (show INSR Proteins) AND IGF-1 (show IGF1 Proteins) in the lammelar tissue of horses with insulin (show INS Proteins)-induced hyperinsulinemia.

  2. The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.

  3. Somatomedin (IGF-I (show IGF1 Proteins)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]

Human Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. Positive correlations indicated probable cross-talk between the IGF-IR-mediated and adiponectin (show ADIPOQ Proteins)-mediated signaling pathways.

  2. IGF1R is a direct target of miR-494 in epithelial ovarian carcinoma cells. miR-494 overexpression inhibited IGF1R expression and its downstream signal protein expression. IGF1R downregulation has similar effects to miR-494 overexpression on EOC cells, and overexpression of IGF1R effectively rescued the inhibition of overexpressed miR-494 in EOC cells. miR-494 directly binds the IGF1R 3'-UTR.

  3. identification of IGF-1R in odontogenic myxoma is shared with numerous tumours and indicates the ability of these tumour cells to respond to growth factors

  4. NANOG (show NANOG Proteins) was regulated by extracellular IGF signaling pathway via STAT3 (show STAT3 Proteins) phosphorylation in colorectal cancer (CRC (show CALR Proteins)). This coincides with that IGF receptor IGF-1R is often increasing expressed in malignant metastasis colon cancer. Taken together, our data define the crucial functions of IGF/STAT3 (show STAT3 Proteins)/NANOG (show NANOG Proteins)/Slug (show SNAI2 Proteins) signaling axis in the progression of CRC (show CALR Proteins)

  5. This study suggests IGF1R as a potential biomarker of improved clinical outcome in HR+ve breast cancer patients treated with exemestane. Adding metformin to exemestane treatment may add to this effect

  6. We present multiplexed RO assays for an IGF1R-EGFR (show EGFR Proteins) bispecific antibody (Bs-Ab) and a CTLA4 (show CTLA4 Proteins)-Ig recombinant fusion protein to demonstrate key considerations for accurate RO assessment.

  7. IGF1 (show IGF1 Proteins) pro-forms can induce breast cancer cell proliferation via the IGF1R, independent from the mature IGF1 (show IGF1 Proteins) form.

  8. p53 (show TP53 Proteins) R273H mutation unleashes the inhibition effect of miR (show MLXIP Proteins)-30a on IGF-1R expression, thus leading to elevated activation of IGF-1R-AKT (show AKT1 Proteins) signaling cascade in tumor cells.

  9. miR (show MLXIP Proteins)-214 significantly blocked IGF-1R-forced renal cancer cell proliferation, which was reversed by expression of 3'UTR-less IGF-1R and constitutively active mTORC1.

  10. The findings suggest that miR (show MLXIP Proteins)-98 inhibits cancer cell growth and metastasis by direct targeting IGF1R, implicating miR (show MLXIP Proteins)-98 as a novel potential therapeutic target for oral squamous cell carcinoma (OSCC).

Pig (Porcine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. IGF-I (show IGF1 Proteins), IGF-II, and IGFBP-3 (show IGFBP3 Proteins) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.

  2. IL-1beta (show IL1B Proteins) impaired the actions of IGF-I (show IGF1 Proteins) at a point distal to the IGF receptor

  3. IGF-1R is expressed in porcine somatostatin (show SST Proteins)-containing islet D-cells

  4. This study suggests an association between the affinity of insulin (show INS Proteins) receptors and number of IGF-1 (show IGF1 Proteins) receptors with placental and/or fetal growth.

  5. mRNA expression of IGF-I receptor

Cow (Bovine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. study determined IGFR1 and PAPP-A (show PAPPA Proteins) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Proteins)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (show PAPPA Proteins) secretion as a modulator of IGF1 (show IGF1 Proteins) in cattle with COD (show SNRPB Proteins)

  2. Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.

  3. two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle

  4. insulin (show INS Proteins)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization

  5. The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.

  6. Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 Proteins), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.

  7. Results do not support the premise that increased apoptosis associated with high levels of IGF1 (show IGF1 Proteins) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.

  8. IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR (show FRAP1 Proteins) activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.

  9. IGF-1 (show IGF1 Proteins) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.

  10. granulosa cell clustering is accompanied by marked increases in FSHr (show FSHR Proteins), IGF-1r, and p450 arom (show CYP19A1 Proteins) expression, and precedes induction and subsequent peak E2 production

Mouse (Murine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. Macrophage IGF1R signaling suppresses macrophage and foam cell accumulation in lesions and reduces plaque vulnerability, providing a novel mechanism whereby IGF-1 (show IGF1 Proteins) exerts antiatherogenic effects in ApoE (show APOE Proteins) knockout mice.

  2. study recognized the promotion of miR (show MLXIP Proteins)-223 level by AGE-BSA treatment in osteoblast-like MC3T3-E1 cells. The promoted miR (show MLXIP Proteins)-223 targeted IGF-1R and mediated the AGE-BSA-induced apoptosis in MC3T3-E1 cells.

  3. osterix (show SP7 Proteins) is a downstream target of IGF1R in chondrocytes.

  4. NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-195/497-Igf1r/Insr (show INSR Proteins)-Ccnd2 (show CCND2 Proteins)/Ccne1 (show CCNE1 Proteins) plays important roles in myogenesis.

  5. this study, we have characterized epigenetic changes following pregnancy and found that Igf1r and other IGF family members are hypermethylated and downregulated.

  6. IGF1R signaling was necessary for DC-mediated T-ALL survival.

  7. mitochondria, activated by IGF-1R signaling, constitute a critical regulator of information processing in hippocampal neurons.

  8. IGF1R is involved in osteoblast differentiation during fracture repair and it plays an important role in coordinating chondrocyte, osteoclast, and endothelial responses that contribute to endochondral bone formation required for normal fracture repair

  9. ectopic down-regulation of IGF1R reversed the protective effect of miR (show MLXIP Proteins)-100 down-regulation on H2O2-induced apoptosis, revealing that miR (show MLXIP Proteins)-100 regulates cardiomyocyte apoptosis through the association of IGF1R.

  10. Data (including data from studies in knockout mice) suggest that Igf1r plays role in cardiomyocytes during ventricular remodeling of aging; deletion of Igf1r in cardiomyocytes attenuates cardiac aging in male mice.

IGF1R Protein Profile

Protein Summary

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Alternative names and synonyms associated with IGF1R

  • insulin-like growth factor 1 receptor (IGF1R)
  • insulin-like growth factor 1 receptor (igf1r)
  • insulin-like growth factor 1 receptor (Igf1r)
  • insulin-like growth factor I receptor (Igf1r)
  • A330103N21Rik protein
  • CD221 protein
  • D930020L01 protein
  • DKFZp469I0618 protein
  • hyft protein
  • IGF-1R protein
  • IGF1R protein
  • IGFIR protein
  • IGFIRC protein
  • IGFR protein
  • IGFR1 protein
  • JTK13 protein
  • xIGF-1R protein
  • xigf1r protein
  • xIGFR protein

Protein level used designations for IGF1R

insulin-like growth factor 1 receptor , IGF-I receptor , insulin-like growth factor I receptor , soluble IGF1R variant 1 , soluble IGF1R variant 2 , insulin-like growth factor-1 receptor beta subunit , xIGF-1R , xIGFR , insulin-like growth factor receptor tyrosine kinase , insulin-like growth factor-I receptor , type 1 IGF receptor , tyrosine kinase , IGF-1 receptor , insulin-like growth factor 1 receptor beta subunit , insulin-like growth factor receptor 1 , insulin-like growth factor-1 receptor , receptor tyrosine kinase , line 186

100055698 Equus caballus
453676 Pan troglodytes
100172156 Pongo abelii
100329112 Xenopus (Silurana) tropicalis
100020095 Monodelphis domestica
3480 Homo sapiens
25718 Rattus norvegicus
398022 Xenopus laevis
395889 Gallus gallus
397350 Sus scrofa
281848 Bos taurus
442951 Canis lupus familiaris
100734840 Cavia porcellus
16001 Mus musculus
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