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Data suggest that, as part of DNA repair in nucleus of embryonic stem cells, IGF1R interacts with and phosphorylates PCNA at tyrosine residues 60, 133, and 250; this is followed by mono- and polyubiquitination of PCNA by RAD18 and SHPRH. (IGF1R = insulin-like growth factor 1 receptor; PCNA = proliferating cell nuclear antigen; RAD18 = E3 ubiquitin-protein ligase RAD18; SHPRH = E3 ubiquitin-protein ligase SHPRH)
These data suggest the involvement of IGF-2, IGF-1R, IGF-2R and PTEN in temporo-spatial patterning of basic cellular processes (proliferation, differentiation) during normal tooth development.
Genetic variants in the IGF1 (show IGF1 Proteins) and IGF1R genes might not be associated with high myopia in Han Chinese. Further studies are needed to verify the possible function of IGF1 (show IGF1 Proteins) and IGF1R in the development of myopia.
Small interfering RNA-mediated IGF-1R knockdown mimics the effects of miR (show MLXIP Proteins)-375 up-regulation, while overexpression of Insulin Like Growth Factor 1 Receptor partially reverses those effects in oral squamous cell carcinoma cells.
miR (show MLXIP Proteins)-30a suppressed migration and invasion through the IGF1R/p-AKT (show AKT1 Proteins)/b-catenin/E-cadherin (show CDH1 Proteins) pathway in colorectal cancer cells.
Results detected IGF1R gene amplification and that it was correlated with high levels of mRNA and protein expression in type IV gastric neoplasm.
Signaling via the insulin (INS (show INS Proteins)) and insulin-like growth factor 1 (IGF1 (show IGF1 Proteins)) receptors (INSR (show INSR Proteins) and IGF1R) regulate basal cell (BC) differentiation into ciliated cells.
Ultravioet rays-induced DNA repair in geriatric keratinocytes is due in part to silenced IGF-1R activation.
demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 (show GRK5 Proteins) and GRK6 (show GRK6 Proteins), both of which regulate Src (show SRC Proteins) and IGF-IR signaling and have been implicated in cancer.
This meta-analysis revealed that high expression of IGF-1R was associated with poor prognosis in non-small cell lung cancer.
A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.
study determined IGFR1 and PAPP-A (show PAPPA Proteins) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Proteins)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (show PAPPA Proteins) secretion as a modulator of IGF1 (show IGF1 Proteins) in cattle with COD (show SNRPB Proteins)
Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.
two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle
insulin (show INS Proteins)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 Proteins), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Results do not support the premise that increased apoptosis associated with high levels of IGF1 (show IGF1 Proteins) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.
IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR (show FRAP1 Proteins) activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.
IGF-1 (show IGF1 Proteins) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.
IGF-I (show IGF1 Proteins), IGF-II, and IGFBP-3 (show IGFBP3 Proteins) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
IL-1beta (show IL1B Proteins) impaired the actions of IGF-I (show IGF1 Proteins) at a point distal to the IGF receptor
IGF-1R is expressed in porcine somatostatin (show SST Proteins)-containing islet D-cells
This study suggests an association between the affinity of insulin (show INS Proteins) receptors and number of IGF-1 (show IGF1 Proteins) receptors with placental and/or fetal growth.
mRNA expression of IGF-I receptor
let-7g regulates autophagy in mouse granulosa cells by targeting insulin-like growth factor 1 receptor and downregulating protein kinase B (show AKT1 Proteins)/mammalian target of rapamycin (show FRAP1 Proteins) signaling
VEGF (show VEGFA Proteins) and IGF1 (show IGF1 Proteins) were critical factors for the spontaneous cardiac differentiation of BATDCs, and MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) signaling was involved in the role of VEGF (show VEGFA Proteins) and IGF1 (show IGF1 Proteins).
miR (show MLXIP Proteins)-223/IGF-IR signalling pathway is regulated in parallel in both the lung vasculature and the right ventricle under conditions of hypoxia induced pulmonary hypertension.
Data (including data from studies using heterozygous transgenic mice) suggest that gene expression in liver is altered in a model of inflammation of liver due to partial deficiency of Igf1 (show IGF1 Proteins); this leads to over-expression of Igf1 (show IGF1 Proteins) receptor, inflammation mediators, and acute-phase proteins, but under-expression of cytoskeletal proteins, extracellular matrix proteins, and tight junction proteins.
Findings indicate that the energy-sensing LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins) pathway regulates IGF1 (show IGF1 Proteins) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R-PKB (show AKT2 Proteins) pathway.
IGF1R has a crucial role in granulosa cells function and, consequently, in female fertility.
Ubiquitous inducible IGF-1R knockout (UBIKOR) mice were strikingly lean with coordinate changes in body composition and organ size. They were insulin (show INS Proteins) resistant but preserved physiological energy expenditure and displayed enhanced fasting metabolic flexibility.
the overlap of IR and IGF1R signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (show FOXO3 Proteins)-regulated, autophagy-mediated protein degradation
SUMOylation of IGF1R affects upstream mechanisms that control and coordinate expression of cell cycle regulators to increase cell cycle progression and proliferation.
findings demonstrated that significant resistance of the brain to amyloid-beta can be achieved lifelong by suppressing neuronal IGF1R.
This study evaluated the expression of IGF-1 (show IGF1 Proteins) receptor, insulin receptor (show INSR Proteins) AND IGF-1 (show IGF1 Proteins) in the lammelar tissue of horses with insulin (show INS Proteins)-induced hyperinsulinemia.
The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.
Somatomedin (IGF-I (show IGF1 Proteins)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
, insulin-like growth factor I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor receptor tyrosine kinase
, insulin-like growth factor-I receptor
, type 1 IGF receptor
, tyrosine kinase
, IGF-1 receptor
, insulin-like growth factor 1 receptor beta subunit
, insulin-like growth factor receptor 1
, insulin-like growth factor-1 receptor
, receptor tyrosine kinase
, insulin-like growth factor 1 receptor
, line 186
, insulin-like growth factor-1 receptor beta subunit