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Browse our IGF1R Proteins (IGF1R)

Full name:
Insulin-Like Growth Factor 1 Receptor Proteins (IGF1R)
On are 39 Insulin-Like Growth Factor 1 Receptor (IGF1R) Proteins from 15 different suppliers available. Additionally we are shipping IGF1R Antibodies (470) and IGF1R Kits (46) and many more products for this protein. A total of 571 IGF1R products are currently listed.
A330103N21Rik, CD221, D930020L01, DKFZp469I0618, hyft, IGF-1R, IGF1R, IGFIR, IGFIRC, IGFR, IGFR1, JTK13, xIGF-1R, xigf1r, xIGFR
list all proteins Gene Name GeneID UniProt
IGF1R 3480 P08069
IGF1R 25718 P24062
IGF1R 16001 Q60751

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IGF1R Proteins (IGF1R) by Origin

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Top referenced IGF1R Proteins

  1. Human IGF1R Protein expressed in Human Cells - ABIN2002215 : Tollefsen, Stoszek, Thompson: Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation. in Biochemistry 1991 (PubMed)
    Show all 5 references for ABIN2002215

More Proteins for IGF1R Interaction Partners

Horse (Equine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. This study evaluated the expression of IGF-1 (show IGF1 Proteins) receptor, insulin receptor (show INSR Proteins) AND IGF-1 (show IGF1 Proteins) in the lammelar tissue of horses with insulin (show INS Proteins)-induced hyperinsulinemia.

  2. The laminar cell types expressing insulin receptor (show INSR Proteins) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.

  3. Somatomedin (IGF-I (show IGF1 Proteins)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]

Human Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. Previously characterized disease-causing mutations in IGF2, IGF1R, IGF2R (show IGF2R Proteins), or IGFALS (show IGFALS Proteins) all were found in the general population but with allele frequencies of <1:30,000.

  2. These results indicate that mutagenesis and skin carcinogenesis in IGF-1 (show IGF1 Proteins)-deficient geriatric skin may be caused by defects in multiple cellular responses to UVB-induced DNA damage, including through a failure to properly suppress DNA synthesis on UVB-damaged DNA templates.

  3. Authors identified Insulin (show INS Proteins) Growth Factor (IGF)1 (show IGF1 Proteins) receptor as the signal positively regulated by TGFbeta (show TGFB1 Proteins) implicated in ovarian tumor cell proliferation.

  4. IGF-1R downregulation may have a regulatory impact after initiation of hepatic lineage commitment.

  5. Our findings imply that APBB1 (show APBB1 Proteins) plays an important role in the maintenance of EMT (show ITK Proteins)-associated CSC-like properties and gamma-radiation resistance via activation of IGF1Rbeta/AKT (show AKT1 Proteins)/GSK3beta pathway in lung cancer cells, highlighting APBB1 (show APBB1 Proteins) as a potential target for therapeutic cancer treatment.

  6. a straightforward protocol for production of recombinant IGF-II and prepared six IGF-II analogs with IGF-I-like mutations. All modified molecules exhibit significantly reduced affinity toward IR-A, particularly the analogs with a Pro-Gln insertion in the C-domain. Moreover, one of the analogs has enhanced binding affinity for IGF-1R due to a synergistic effect of the Pro-Gln insertion and S29N point mutation.

  7. These results indicate that miR (show MLXIP Proteins)-139 is capable of inhibiting chondrocyte proliferation and migration, thus being a possible therapeutic target for OA. The mechanism of miR (show MLXIP Proteins)-139 in chondrocytes may be related to its regulation on EIF4G2 (show EIF4G2 Proteins) and IGF1R.

  8. Results indicate that recombinant lentiviral vectors provided an efficient and stable knockdown of insulin-like growth factor 1 receptor (IGF-1R) providing useful tool for IGF-1R pathway studies.

  9. Findings indicated both cezanne (show OTUD7B Proteins)-1 and IGF1R expressions were negative independent predictive factors for the prognosis of lung adenocarcinoma, respectively. There was a close positive interrelationship between cezanne (show OTUD7B Proteins)-1 and IGF1R expression.

  10. an IGF-1 (show IGF1 Proteins)/IGF-1R loop could play a role in the tumorigenesis and progression of schwannomas via an autocrine-paracrine mechanism.

Pig (Porcine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. IGF-I (show IGF1 Proteins), IGF-II, and IGFBP-3 (show IGFBP3 Proteins) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.

  2. IL-1beta (show IL1B Proteins) impaired the actions of IGF-I (show IGF1 Proteins) at a point distal to the IGF receptor

  3. IGF-1R is expressed in porcine somatostatin (show SST Proteins)-containing islet D-cells

  4. This study suggests an association between the affinity of insulin (show INS Proteins) receptors and number of IGF-1 (show IGF1 Proteins) receptors with placental and/or fetal growth.

  5. mRNA expression of IGF-I receptor

Cow (Bovine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.

  2. study determined IGFR1 and PAPP-A (show PAPPA Proteins) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (show SNRPB Proteins)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (show PAPPA Proteins) secretion as a modulator of IGF1 (show IGF1 Proteins) in cattle with COD (show SNRPB Proteins)

  3. Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.

  4. two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle

  5. insulin (show INS Proteins)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization

  6. The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.

  7. Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 Proteins), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.

  8. Results do not support the premise that increased apoptosis associated with high levels of IGF1 (show IGF1 Proteins) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.

  9. IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR (show FRAP1 Proteins) activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.

  10. IGF-1 (show IGF1 Proteins) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.

Mouse (Murine) Insulin-Like Growth Factor 1 Receptor (IGF1R) interaction partners

  1. MicroRNA-99a inhibits insulin (show INS Proteins)-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting IGF-1R and mTOR (show FRAP1 Proteins) signaling.

  2. These results indicated that IGF1R may increase cell viability under hypoxic conditions by promoting autophagy and scavenging reactive oxygen species production, which is closed with PI3K/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway.

  3. When charged with hypoxia-ischemia, mutant brains with deleted IGF-1 (show IGF1 Proteins) receptor were broadly protected from cell damage, neuroinflammation and cerebral edema.

  4. Suggest that overexpression of IGF-IR or IRA (show INSR Proteins) isoform, as homodimers or as part of IRA (show INSR Proteins)/IGF-IR hybrid receptors, confers a stronger migratory capability to vascular smooth muscle cells and might occur in early stages of atherosclerotic process.

  5. Macrophage IGF1R signaling suppresses macrophage and foam cell accumulation in lesions and reduces plaque vulnerability, providing a novel mechanism whereby IGF-1 (show IGF1 Proteins) exerts antiatherogenic effects in ApoE (show APOE Proteins) knockout mice.

  6. study recognized the promotion of miR (show MLXIP Proteins)-223 level by AGE-BSA treatment in osteoblast-like MC3T3-E1 cells. The promoted miR (show MLXIP Proteins)-223 targeted IGF-1R and mediated the AGE-BSA-induced apoptosis in MC3T3-E1 cells.

  7. osterix (show SP7 Proteins) is a downstream target of IGF1R in chondrocytes.

  8. NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-195/497-Igf1r/Insr (show INSR Proteins)-Ccnd2 (show CCND2 Proteins)/Ccne1 (show CCNE1 Proteins) plays important roles in myogenesis.

  9. this study, we have characterized epigenetic changes following pregnancy and found that Igf1r and other IGF family members are hypermethylated and downregulated.

  10. IGF1R signaling was necessary for DC-mediated T-ALL survival.

IGF1R Protein Profile

Protein Summary

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Alternative names and synonyms associated with IGF1R

  • insulin-like growth factor 1 receptor (IGF1R)
  • insulin-like growth factor 1 receptor (igf1r)
  • insulin-like growth factor 1 receptor (Igf1r)
  • insulin-like growth factor I receptor (Igf1r)
  • A330103N21Rik protein
  • CD221 protein
  • D930020L01 protein
  • DKFZp469I0618 protein
  • hyft protein
  • IGF-1R protein
  • IGF1R protein
  • IGFIR protein
  • IGFIRC protein
  • IGFR protein
  • IGFR1 protein
  • JTK13 protein
  • xIGF-1R protein
  • xigf1r protein
  • xIGFR protein

Protein level used designations for IGF1R

insulin-like growth factor 1 receptor , IGF-I receptor , insulin-like growth factor I receptor , soluble IGF1R variant 1 , soluble IGF1R variant 2 , insulin-like growth factor-1 receptor beta subunit , xIGF-1R , xIGFR , insulin-like growth factor receptor tyrosine kinase , insulin-like growth factor-I receptor , type 1 IGF receptor , tyrosine kinase , IGF-1 receptor , insulin-like growth factor 1 receptor beta subunit , insulin-like growth factor receptor 1 , insulin-like growth factor-1 receptor , receptor tyrosine kinase , line 186

100055698 Equus caballus
453676 Pan troglodytes
100172156 Pongo abelii
100329112 Xenopus (Silurana) tropicalis
100020095 Monodelphis domestica
3480 Homo sapiens
25718 Rattus norvegicus
398022 Xenopus laevis
395889 Gallus gallus
397350 Sus scrofa
281848 Bos taurus
442951 Canis lupus familiaris
100734840 Cavia porcellus
16001 Mus musculus
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