IGF1R Protein (AA 31-936) (His tag)
Quick Overview for IGF1R Protein (AA 31-936) (His tag) (ABIN6253547)
Target
See all IGF1R ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 31-936
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Purification tag / Conjugate
- This IGF1R protein is labelled with His tag.
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Sequence
- AA 31-936
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 31-932) protein (His-Avi Tag)
IGF1R Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE, > 95 % as determined by HPLC
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 31-932) (Active) protein (Biotin,His-Avi Tag)IGF1R Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 31-932) (Active) protein (His tag)IGF1R Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 31-936) protein (His tag)IGF1R Origin: Mouse Host: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 741-935) protein (His-IF2DI Tag)IGF1R Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 31-932) protein (His tag)IGF1R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 741-935) protein (His-DYKDDDDK-Strep II Tag)IGF1R Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 31-932) protein (His tag)IGF1R Origin: Cynomolgus Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
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Alternative Name
- IGF-I R
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Background
- The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60 % homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.
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Molecular Weight
- 81.3 kDa and 24.2 kDa
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NCBI Accession
- NP_434694
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Pathways
- RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy
Target
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