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anti-Mouse (Murine) NFAT5 Antibodies:
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Hamster Polyclonal NFAT5 Primary Antibody for ChIP, GS - ABIN267152
Johnson, Shapiro, Risbud: RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE? in The Journal of biological chemistry 2016
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NFAT5 can modulate different T-cell responses depending on stress conditions and stimulatory context.
results provide evidence that NFAT5 expression in macrophages enhances chronic arthritis by conferring apoptotic resistance to activated macrophages.
In vivo, osmotic stress up-regulates the SCTR (show SCTR Antibodies) gene in the kidney cortex and medulla of wild-type mice, but does not do so in NFAT5(+/-) mice.
TonEBP suppresses adipogenesis and insulin (show INS Antibodies) sensitivity by blocking epigenetic transition of PPARgamma2 (show PPARG Antibodies)
TonEBP is a critical regulator of neuroinflammation and blood-brain barrier leakage in kainic acid-induced seizures.
PKC-alpha (show PKCa Antibodies) contributes to high NaCl-dependent activation of NFAT5 through ERK1/2 (show MAPK1/3 Antibodies).
these data support a novel function of the XO-NFAT5 axis in macrophage activation and TLR-induced arthritis
Suggest that biomechanical stretch is sufficient to activate NFAT5 both in native and cultured VSMCs where it regulates the expression of tenascin-C (show TNC Antibodies).
Together, these results clearly demonstrated that hyperglycemia-induced TonEBP plays a crucial role in increasing aldose reductase (show AKR1B1 Antibodies) and PKCdelta (show PKCd Antibodies) levels and leading to apoptotic death.
Data indicate that in transgenic mice overexpressing Sfmbt2 10th intron-hosted miR (show MLXIP Antibodies)-466a-3p, significant down-regulation of Nfat5 and many other osmoregulation-related genes was observed in both the renal cortex and medulla.
TonEBP expression correlated with canonical osmoregulatory targets TauT/SLC6A6 (show TAUT Antibodies), SMIT/SLC5A3 (show SLC5A3 Antibodies), and AR/AKR1B1 (show AKR1B1 Antibodies), supporting in vitro findings that the inflammatory milieu during IDD (show COL9A3 Antibodies) does not interfere with TonEBP osmoregulation. In summary, whereas TonEBP participates in the proinflammatory response to TNF-alpha (show TNF Antibodies)
genetic variation in NFAT5 expression and function in the central nervous system may affect the regulation of systemic water balance
The hyperosmotic AR gene expression was dependent on activation of metalloproteinases, autocrine/paracrine TGF-beta (show TGFB1 Antibodies) signaling, activation of p38 MAPK (show MAPK14 Antibodies), ERK1/2 (show MAPK1/3 Antibodies), and PI3K (show PIK3CA Antibodies) signal transduction pathways, and the transcriptional activity of NFAT5.
Conclusion. miR (show MLXIP Antibodies)-20b acts as a tumor suppressor in the development of thymoma and thymoma-associated myasthenia gravis. The tumor suppressive function of miR (show MLXIP Antibodies)-20b in thymoma could be due to its inhibition of NFAT (show NFATC1 Antibodies) signaling by repression of NFAT5 and CAMTA1 (show CAMTA1 Antibodies) expression.
The hyperosmotic, but not the hypoxic, PlGF (show PGF Antibodies) gene expression was in part mediated by NFAT5.
Proteins associated with and binding NH2-terminal region of NFAT5.NUP160 (show NUP160 Antibodies) and NUP205 contribute to regulation of NFAT5 transcriptional activity
Our data demonstrates the involvement of TonEBP in the mechanisms responsible for osmoadaptation to hyperosmolar stress in retinal pigment epithelium cells.
Additionally, in peritoneal dialysis the cells of the peritoneal cavity are repeatedly exposed to a rise and fall in osmotic concentrations. Here we review the current information about NFAT5 in uremic patients and patients on peritoneal dialysis.
Results suggest that the NFAT5 gene, which is upregulated a few hours after cocaine exposure, may be involved in the genetic predisposition to cocaine dependence.
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.
nuclear factor of activated T-cells 5
, nuclear factor of activated T-cells 5, tonicity-responsive
, nuclear factor of activated T-cells 5-like
, T-cell transcription factor NFAT5
, rel domain-containing transcription factor NFAT5
, tonicity-responsive enhancer binding protein
, NFAT-like protein 1
, TonE-binding protein
, glutamine rich protein H65
, osmotic response element-binding protein
, tonicity-responsive enhancer-binding protein