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Browse our anti-PAK4 (PAK4) Antibodies

Full name:
anti-P21-Activated Kinase 4 Antibodies (PAK4)
On www.antibodies-online.com are 174 P21-Activated Kinase 4 (PAK4) Antibodies from 26 different suppliers available. Additionally we are shipping PAK4 Proteins (24) and PAK4 Kits (2) and many more products for this protein. A total of 212 PAK4 products are currently listed.
Synonyms:
5730488L07Rik, AW555722, mKIAA1142
list all antibodies Gene Name GeneID UniProt
PAK4 10298 O96013
PAK4 70584 Q8BTW9
PAK4 292756  

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anti-Human PAK4 Antibodies:

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anti-Rat (Rattus) PAK4 Antibodies:

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Top referenced anti-PAK4 Antibodies

  1. Human Monoclonal PAK4 Primary Antibody for WB - ABIN967342 : Abo, Qu, Cammarano, Dan, Fritsch, Baud, Belisle, Minden: PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. in The EMBO journal 1999 (PubMed)
    Show all 2 references for ABIN967342

  2. Bat Polyclonal PAK4 Primary Antibody for WB - ABIN610860 : Jones, Jakubowicz, Pitossi, Maurer, Hemmings: Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 2 references for ABIN610860

  3. Human Polyclonal PAK4 Primary Antibody for EIA, IHC (p) - ABIN360324 : Lu, Pan, Devaux, Ray: p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN360324

  4. Human Polyclonal PAK4 Primary Antibody for ELISA, IF - ABIN4343475 : Liu, Yang, Liu, Liu, Zhang, Xu, Zhu, Xu: p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma. in Urologic oncology 2015 (PubMed)

More Antibodies against PAK4 Interaction Partners

Human P21-Activated Kinase 4 (PAK4) interaction partners

  1. Study demonstrated that PAK4 interacted with eEF1A1 (show EEF1A1 Antibodies) to promote migration and invasion of gastric cancer cells, thereby providing new insights into the function of PAK4 and eEF1A1 (show EEF1A1 Antibodies) in the progression of gastric cancer.

  2. The results support a novel connection between HIF-1a (show HIF1A Antibodies) and Pak4 in hypoxic cancer cells, and provide insights into mechanisms whereby tumors respond to and thrive under oxygen-deficient conditions.

  3. Data suggest that signaling via ANP (show NPPA Antibodies)/ANPR (atrial natriuretic factor/ANP (show NPPA Antibodies) receptor (show PPP5C Antibodies)) in vascular endothelial cells activates PAK4 (p21-activated kinase 4) and CCM2 (cerebral cavernous malformation 2 (show CCM2 Antibodies) protein), resulting in phosphorylation of MLC (myosin light chain), cytoskeletal reorganization, and cell spreading; kinase homology domain of ANPRA (guanylyl cyclase-A (show NPR1 Antibodies)) activates downstream targets of ANP (show NPPA Antibodies)/ANPR signaling.

  4. High expression of PAK4 is associated with breast cancer.

  5. In gastric cancer, High PAK4 expression was significantly correlated with clinicopathological variables related to tumour progression, including depth of invasion, metastatic lymph nodes, pathological stage, distant metastasis or recurrent disease. High PAK4 expression was significantly associated with poorer disease-specific survival and relapse-free survival.

  6. PAK4 methylation by SETD6 (show SETD6 Antibodies) promotes the activation of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway.

  7. Study has confirms prognostic role of PAK4 level in cervical cancer patients and recognizes the regulatory role in cervical cancer progression. PAK4 also confers the chemoresistance of cervical cancer cells in a PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)-dependent way.

  8. PAK4 catalytic domain binds cellular ATP and the Inka1 inhibitor. The crystal lattice consists only of PAK4-PAK4 contacts, which form a hexagonal array with channels of 80 A in diameter that run the length of the crystal.

  9. PAK4 localizes to cell-cell junctions and contributes to estblishing cell polarity.PAK4 phosphorylate beta-catenin (show CTNNB1 Antibodies) Serine-675.PAK4 binding to cell-cell junctions is dependent on Cdc42 (show CDC42 Antibodies).

  10. Nuclear Pak4 is involved in the pathogenesis of endometrial cancer especially in postmenopausal women.

Mouse (Murine) P21-Activated Kinase 4 (PAK4) interaction partners

  1. PAK4 microparticles may have a role in the ventilation-induced lung injury process

  2. These data demonstrate the relevance of PAK4 in osteoclast differentiation and the potential of PAK4 inhibitors for treating osteoclast-related disorders.

  3. PAK4 promotes alpha-MSH/UVB-induced melanogenesis via the CREB (show CREB1 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathways and suggest that PAK4 may be a potential therapeutic target in pigmentation disorders.

  4. PAK4 phosphorylates Par6B (show PARD6B Antibodies) at Ser143 blocking its interaction with Cdc42 (show CDC42 Antibodies).

  5. Defined here is the overlap in phosphopeptides regulated by K-Ras (show HRAS Antibodies), Cdc42 (show CDC42 Antibodies), and PAK4; perturbation of these signaling components affects phosphoproteins associated with microtubule depolymerization, cytoskeletal organization, and the cell cycle.

  6. These results indicate that PAK4 functions, including control of actin dynamics, are necessary for normal development of the heart

  7. p21-activated kinase 4 regulates regulatory myosin light chain phosphorylation and myosin contractility during FcgammaR-mediated phagocytosis.

  8. the transient increase in PAK4 levels at early G1 reduces p21 (show D4S234E Antibodies) levels, thereby abrogating the activity of CDK4 (show CDK4 Antibodies)/CDK6 (show CDK6 Antibodies) kinases, and allowing cells to proceed with the cell cycle in a precisely coordinated way

  9. Conditional Pak4 knockout mice were born normally, but displayed growth retardation and died prematurely. The brains showed a dramatic decrease in proliferation of cortical and striatal neuronal progenitor cells.

  10. results suggest that overexpression of Pak4 triggers events that are important for the transformation of mammary epithelial cells

PAK4 Antigen Profile

Antigen Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with PAK4

  • p21 protein (Cdc42/Rac)-activated kinase 4 (PAK4) antibody
  • p21-activated kinase 4 (LOC100336246) antibody
  • p21 protein (Cdc42/Rac)-activated kinase 4 (Pak4) antibody
  • 5730488L07Rik antibody
  • AW555722 antibody
  • mKIAA1142 antibody

Protein level used designations for PAK4

p21-activated kinase 4 , PAK-4 , p21(CDKN1A)-activated kinase 4 , protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs , serine/threonine-protein kinase PAK 4 , p21 (CDKN1A)-activated kinase 4

GENE ID SPECIES
100067000 Equus caballus
100336246 Bos taurus
10298 Homo sapiens
70584 Mus musculus
292756 Rattus norvegicus
484513 Canis lupus familiaris
770462 Gallus gallus
539742 Bos taurus
100341934 Oryctolagus cuniculus
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