PAK4 Products
(P21-Activated Kinase 4 (PAK4))
Categories
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured PAK4 Categories
PAK4 Antibodies
High quality antibodies with extensive validation data.
PAK4 ELISA Kits
Reliable ELISA kits for a wide range of species.
PAK4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PAK4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7439984
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7169132
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, FACS
Validations
- (5)
Cat. No.
ABIN3032118
Quantity
0.4 mL
Datasheet
Datasheet
Recommended PAK4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958368
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5564605
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1571715
Quantity
96 tests
Datasheet
Datasheet
Recommended PAK4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569703
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN5569960
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (2)
Cat. No.
ABIN5570591
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PAK4 products
: "p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammation in Astrocytes." in: Frontiers in cellular and infection microbiology, Vol. 7, pp. 271, (2018) (PubMed).: "Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum." in: Journal of virology, Vol. 91, Issue 6, (2017) (PubMed).
: "p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma." in: Urologic oncology, Vol. 33, Issue 5, pp. 205.e13-21, (2015) (PubMed).
: "p21-Activated kinase 4 promotes prostate cancer progression through CREB." in: Oncogene, Vol. 32, Issue 19, pp. 2475-82, (2013) (PubMed).
: "p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 43, pp. 18622-7, (2010) (PubMed).
: "Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor." in: Molecular and cellular biology, Vol. 29, Issue 11, pp. 3018-32, (2009) (PubMed).
: "Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling." in: Journal of cell science, Vol. 121, Issue Pt 7, pp. 989-1001, (2008) (PubMed).
: "p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD." in: Molecular and cellular biology, Vol. 23, Issue 16, pp. 5526-39, (2003) (PubMed).
: "p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death." in: The Journal of biological chemistry, Vol. 278, Issue 12, pp. 10374-80, (2003) (PubMed).
: "p21-activated kinases: three more join the Pak." in: The international journal of biochemistry & cell biology, Vol. 34, Issue 7, pp. 713-7, (2002) (PubMed).
Synonyms and alternative names related to PAK4
p21 (RAC1) activated kinase 4 (PAK4), p21 protein (Cdc42/Rac)-activated kinase 4 (Pak4), p21 (RAC1) activated kinase 4 (Pak4), p21 protein (Cdc42/Rac)-activated kinase 4 (pak4), 5730488L07Rik, AW555722, im:5916170, mKIAA1142, wu:fd12b01, zgc:92014Protein level used designations for PAK4
- PAK-4
- p21(CDKN1A)-activated kinase 4
- p21-activated kinase 4
- protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
- serine/threonine-protein kinase PAK 4
- p21 (CDKN1A)-activated kinase 4
- p21 protein (Cdc42/Rac)-activated kinase 4
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