Browse our Phospholipase C gamma 1 Proteins (PLCG1)

Full name:
phospholipase C, gamma 1 Proteins (PLCG1)
On are 6 phospholipase C, gamma 1 (PLCG1) Proteins from 5 different suppliers available. Additionally we are shipping Phospholipase C gamma 1 Antibodies (299) and Phospholipase C gamma 1 Kits (40) and many more products for this protein. A total of 355 Phospholipase C gamma 1 products are currently listed.
AI894140, Cded, NCKAP3, Phosphb, PLC'1, Plc-1, Plc-gamma1, PLC-II, PLC1, PLC148, PLCbeta1, Plcg-1, PLCgamma1, PPLCA, RATPHOSPHB
list all proteins Gene Name GeneID UniProt
Rat PLCG1 PLCG1 24654 P10687
PLCG1 5335 P19174
PLCG1 18803 Q62077

Show all synonyms

Phospholipase C gamma 1 Proteins (PLCG1) by Origin

Select your origin of interest

More Proteins for Phospholipase C gamma 1 Interaction Partners

Human phospholipase C, gamma 1 (PLCG1) interaction partners

  1. These results suggest that immobilized EGF (show EGF Proteins) increases collective keratinocyte displacement via an increase in single-cell migration persistence resulting from altered EGFR (show EGFR Proteins) trafficking and PLCgamma1 activation.

  2. High PLC (show HSPG2 Proteins) gamma expression is associated with breast cancer.

  3. We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt (show AKT1 Proteins). As well as defining a novel mechanism of Akt (show AKT1 Proteins) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2 (show FGFR2 Proteins), Plc11 and Grb2 (show GRB2 Proteins) correlate with patient survival

  4. These results indicate that PP1 (show PPA1 Proteins) is recruited to the extracellular calcium-dependent E-cadherin (show CDH1 Proteins)-catenin-PIP5K1a (show PIP5K1A Proteins) complex in the plasma membrane to activate PIP5K1a (show PIP5K1A Proteins), which is required for PLC (show HSPG2 Proteins)-g1 activation leading to keratinocyte differentiation.

  5. FGFR1 (show FGFR1 Proteins) dimers forms a complex with its effector PLCgamma1.

  6. High PLC gamma1 expression is associated with gastric adenocarcinoma.

  7. Report PLCG1 genetic alterations in angiosarcomas.

  8. expression of PLC-gamma1 and PIKE (show AGAP2 Proteins) positively correlated with the tumor differentiation of oral squamous cell carcinoma.

  9. In a transgenic mouse model, PLCgamma1 is the dominant signaling effector by which activation of TrkB (show NTRK2 Proteins) promotes epilepsy.

  10. hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-665 and hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-95 were downregulated in GSRCC but upregulated in intestinal gastric adenocarcinoma, and the relatively differential expression of the miRNAs negatively controlling their target genes, GLI2 and PLCG1

Mouse (Murine) phospholipase C, gamma 1 (PLCG1) interaction partners

  1. our studies demonstrate that PLCgamma1 is important for pre-TCR mediated signal transduction and pre-T cell development.

  2. Knock-down of PLC-gamma-1 induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 (show RUNX1 Proteins) and subsequent PU.1 upregulation while subsequent rescue of RUNX1 (show RUNX1 Proteins) in sh-PLC-gamma-1-transfected cells strongly inhibited foreign body giant cell formation.

  3. study shows that PLCgamma1 controls osteoclast numbers via a CSF-1 (show CSF1 Proteins)-dependent DAG/beta-catenin (show CTNNB1 Proteins)/cyclinD1 pathway.

  4. this study shows that PLC-gamma1 contributes to protective activity of LAT (show LAT Proteins) activity in vivo

  5. PLCgamma1 signaling is involved in the formation of neuronal processes for functionally faithful brain development. [review]

  6. FGFR1 (show FGFR1 Proteins)/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1.

  7. platelet activation through GPVI (show GP6 Proteins) and alphaIIbbeta3 utilizes PLCgamma2 (show PLCG2 Proteins) because PLCgamma1 levels are insufficient to support responsiveness, but that PLCgamma1 can restore responsiveness if expressed at levels normally achieved by PLCgamma2 (show PLCG2 Proteins).

  8. foci are polymerized de novo as a result of the T cell receptor (TCR) proximal tyrosine kinase (show TYRO3 Proteins) cascade, and facilitate distal signaling events including PLCgamma1 activation and subsequent cytoplasmic calcium ion elevation

  9. The result indicate that LAT (show LAT Proteins)-PLCg1 interaction is important for controlling IL-6 (show IL6 Proteins) production by T cells and demonstrate a critical role of IL-6 (show IL6 Proteins) in the development of the lymphoproliferative syndrome.

  10. low level of LAT (show LAT Proteins)-PLC-gamma1 interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.

Cow (Bovine) phospholipase C, gamma 1 (PLCG1) interaction partners

  1. This study is the first to indicate that PLC gamma 1 is expressed in bovine adrenal chromaffin cells and has the potential to be activated.

  2. Tyrosine775 is identified as a new, functionally important phosphorylation site on PLC gamma 1; phosphorylation of both Y775 and Y783 is required for PLC gamma 1 activation as measured by antigen receptor-induced Ca2 (show CA2 Proteins)+ flux, NF-AT (show NFATC3 Proteins) and AP-1 (show JUN Proteins) activation.

  3. PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src (show SRC Proteins) homology (SH2C) domain.

Phospholipase C gamma 1 (PLCG1) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Phospholipase C gamma 1 (PLCG1)

  • phospholipase C, beta 1 (phosphoinositide-specific) (Plcb1)
  • phospholipase C, gamma 1 (plcg1)
  • phospholipase C, gamma 1 (PLCG1)
  • phospholipase C, gamma 1 (Plcg1)
  • phospholipase C, gamma 1 (LOC100349958)
  • AI894140 protein
  • Cded protein
  • NCKAP3 protein
  • Phosphb protein
  • PLC'1 protein
  • Plc-1 protein
  • Plc-gamma1 protein
  • PLC-II protein
  • PLC1 protein
  • PLC148 protein
  • PLCbeta1 protein
  • Plcg-1 protein
  • PLCgamma1 protein
  • PPLCA protein
  • RATPHOSPHB protein

Protein level used designations for PLCG1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 , 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 , PLC-154 , PLC-I , PLC-beta-1 , Phospholipase C-beta1 , phosphoinositide phospholipase C , phosphoinositide phospholipase C-beta-1 , phospholipase C-I , phospholipase C-beta-1 , PLC gamma 1 , phospholipase C-gamma-1b , phospholipase C, gamma 1 , 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate , 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 , 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 , 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 , PLC-148 , PLC-gamma-1 , inositoltrisphosphohydrolase , monophosphatidylinositol phosphodiesterase , phosphatidylinositol phospholipase C , phosphoinositidase C , phosphoinositide phospholipase C-gamma-1 , phospholipase C, gamma 1 (formerly subtype 148) , phospholipase C-148 , phospholipase C-II , phospholipase C-gamma-1 , triphosphoinositide phosphodiesterase , cell differentiation and embryonic development , PLC-II

24654 Rattus norvegicus
398359 Xenopus laevis
100633163 Amphimedon queenslandica
5335 Homo sapiens
18803 Mus musculus
25738 Rattus norvegicus
281987 Bos taurus
100716986 Cavia porcellus
100349958 Oryctolagus cuniculus
485874 Canis lupus familiaris
419175 Gallus gallus
101103341 Ovis aries
Selected quality suppliers for Phospholipase C gamma 1 Proteins (PLCG1)
Did you look for something else?