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Browse our Phospholipase C gamma 1 Proteins (PLCG1)

Full name:
phospholipase C, gamma 1 Proteins (PLCG1)
On www.antibodies-online.com are 5 phospholipase C, gamma 1 (PLCG1) Proteins from 4 different suppliers available. Additionally we are shipping Phospholipase C gamma 1 Antibodies (221) and Phospholipase C gamma 1 Kits (60) and many more products for this protein. A total of 296 Phospholipase C gamma 1 products are currently listed.
Synonyms:
AI894140, Cded, NCKAP3, Phosphb, PLC'1, Plc-1, Plc-gamma1, PLC-II, PLC1, PLC148, PLCbeta1, Plcg-1, PLCgamma1, PPLCA, RATPHOSPHB
list all proteins Gene Name GeneID UniProt
Rat PLCG1 PLCG1 24654 P10687
PLCG1 5335 P19174
PLCG1 18803 Q62077

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Phospholipase C gamma 1 Proteins (PLCG1) by Origin

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More Proteins for Phospholipase C gamma 1 Interaction Partners

Human phospholipase C, gamma 1 (PLCG1) interaction partners

  1. Report PLCG1 genetic alterations in angiosarcomas.

  2. expression of PLC-gamma1 and PIKE (show AGAP2 Proteins) positively correlated with the tumor differentiation of oral squamous cell carcinoma.

  3. In a transgenic mouse model, PLCgamma1 is the dominant signaling effector by which activation of TrkB (show NTRK2 Proteins) promotes epilepsy.

  4. hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-665 and hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-95 were downregulated in GSRCC but upregulated in intestinal gastric adenocarcinoma, and the relatively differential expression of the miRNAs negatively controlling their target genes, GLI2 and PLCG1

  5. Results provide evidence that PTPRB (show PTPRB Proteins) and PLCG1 mutations are driving events in a subset of secondary angiosarcomas.

  6. PLCgamma1 is part of the molecular mechanism.

  7. Recurrent presence of the PLCG1 S345F mutation is associated with nodal peripheral T-cell lymphomas.

  8. The degradation of zonula occludens-1 (ZO-1 (show TJP1 Proteins)), and claudin-2 (show CLDN2 Proteins) exhibited a great dependence on the activation of the transient receptor potential melastatin (show TRPM1 Proteins) (TRPM) 2 (show CLU Proteins) channel, phospholipase Cgamma1 (PLCgamma1) and the protein kinase (show CDK7 Proteins) Calpha (show PRKACA Proteins) (PKCalpha (show PKCa Proteins)) signaling cascade.

  9. Data from structural, genetic, and mechanistic studies on the role of PLCG1 in cell biology suggest that dysfunctional forms of PLCG1 are linked to immune disorders and cancer. [REVIEW]

  10. This SOCS7 knockdown-attributed effect could be due to a precise anti-PLCg-1 role.

Mouse (Murine) phospholipase C, gamma 1 (PLCG1) interaction partners

  1. FGFR1 (show FGFR1 Proteins)/2 act in concert to recruit and transphosphorylate phospholipase Cgamma1.

  2. platelet activation through GPVI (show GP6 Proteins) and alphaIIbbeta3 utilizes PLCgamma2 (show PLCG2 Proteins) because PLCgamma1 levels are insufficient to support responsiveness, but that PLCgamma1 can restore responsiveness if expressed at levels normally achieved by PLCgamma2 (show PLCG2 Proteins).

  3. foci are polymerized de novo as a result of the T cell receptor (TCR) proximal tyrosine kinase (show TYRO3 Proteins) cascade, and facilitate distal signaling events including PLCgamma1 activation and subsequent cytoplasmic calcium ion elevation

  4. The result indicate that LAT (show LAT Proteins)-PLCg1 interaction is important for controlling IL-6 (show IL6 Proteins) production by T cells and demonstrate a critical role of IL-6 (show IL6 Proteins) in the development of the lymphoproliferative syndrome.

  5. low level of LAT (show LAT Proteins)-PLC-gamma1 interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.

  6. These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT (show LAT Proteins) and PLCgamma1 in Dow2-induced anergic T cells. The novel CD3 (show CD3E Proteins)-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression

  7. Membrane tethering of PKCdelta (show PKCd Proteins) leads to increased force exertion on extracellular matrix through PLCgamma1/EGFR (show EGFR Proteins) signaling.

  8. EAT-2 (show SH2D1B Proteins) mediates its effects in natural killer cells by linking SLAM (show SLAMF1 Proteins) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 Proteins) kinase.

  9. Data suggest that transmembrane adaptor protein LAT (show LAT Proteins)-PLCgamma1 (Phospholipase C gamma 1) signaling may function differently in various subsets of gammadelta T cells.

  10. Data indicate that mutation of the residues on and adjacent to the G helix within the Itk (show ITK Proteins) kinase domain impairs the catalytic efficacy of PLCgamma1 substrate phosphorylation.

Cow (Bovine) phospholipase C, gamma 1 (PLCG1) interaction partners

  1. This study is the first to indicate that PLC gamma 1 is expressed in bovine adrenal chromaffin cells and has the potential to be activated.

  2. Tyrosine775 is identified as a new, functionally important phosphorylation site on PLC gamma 1; phosphorylation of both Y775 and Y783 is required for PLC gamma 1 activation as measured by antigen receptor-induced Ca2 (show CA2 Proteins)+ flux, NF-AT (show NFATC3 Proteins) and AP-1 (show JUN Proteins) activation.

  3. PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src (show SRC Proteins) homology (SH2C) domain.

Phospholipase C gamma 1 (PLCG1) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Phospholipase C gamma 1 (PLCG1)

  • phospholipase C, beta 1 (phosphoinositide-specific) (Plcb1)
  • phospholipase C, gamma 1 (plcg1)
  • phospholipase C, gamma 1 (PLCG1)
  • phospholipase C, gamma 1 (Plcg1)
  • phospholipase C, gamma 1 (LOC100349958)
  • AI894140 protein
  • Cded protein
  • NCKAP3 protein
  • Phosphb protein
  • PLC'1 protein
  • Plc-1 protein
  • Plc-gamma1 protein
  • PLC-II protein
  • PLC1 protein
  • PLC148 protein
  • PLCbeta1 protein
  • Plcg-1 protein
  • PLCgamma1 protein
  • PPLCA protein
  • RATPHOSPHB protein

Protein level used designations for PLCG1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 , 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 , PLC-154 , PLC-I , PLC-beta-1 , Phospholipase C-beta1 , phosphoinositide phospholipase C , phosphoinositide phospholipase C-beta-1 , phospholipase C-I , phospholipase C-beta-1 , PLC gamma 1 , phospholipase C-gamma-1b , phospholipase C, gamma 1 , 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate , 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 , 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 , 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 , PLC-148 , PLC-gamma-1 , inositoltrisphosphohydrolase , monophosphatidylinositol phosphodiesterase , phosphatidylinositol phospholipase C , phosphoinositidase C , phosphoinositide phospholipase C-gamma-1 , phospholipase C, gamma 1 (formerly subtype 148) , phospholipase C-148 , phospholipase C-II , phospholipase C-gamma-1 , triphosphoinositide phosphodiesterase , cell differentiation and embryonic development , PLC-II

GENE ID SPECIES
24654 Rattus norvegicus
398359 Xenopus laevis
100633163 Amphimedon queenslandica
5335 Homo sapiens
18803 Mus musculus
25738 Rattus norvegicus
281987 Bos taurus
100716986 Cavia porcellus
100349958 Oryctolagus cuniculus
485874 Canis lupus familiaris
419175 Gallus gallus
101103341 Ovis aries
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