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Phospholipase C gamma 1 Products

(phospholipase C, gamma 1 (PLCG1))

Categories

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured Phospholipase C gamma 1 Categories

Phospholipase C gamma 1 Antibodies

High quality antibodies with extensive validation data.

Phospholipase C gamma 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Phospholipase C gamma 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Phospholipase C gamma 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, PLA, ELISA, WB
Validations
  • (1)
  • (7)
Cat. No. ABIN562265
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Monkey, Rat
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (8)
Cat. No. ABIN5542680
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (8)
Cat. No. ABIN5542681
Quantity 0.1 mg
Datasheet Datasheet

Recommended Phospholipase C gamma 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (3)
Cat. No. ABIN6730785
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969307
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958575
Quantity 96 tests
Datasheet Datasheet

Recommended Phospholipase C gamma 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094664
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135496
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315336
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Phospholipase C gamma 1 products

Huang, Wang, Li, Wang, Yan, Zhang, Wang, Huang, Jia, Lu, Liu, Chen, Li, Cai, Jiang, Jin, Bai: "Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone." in: Nature communications, Vol. 7, pp. 13885, (2018) (PubMed).

Zhang, Wang, Zeng, Yan, Ouyang, Liu, Sun, Zhao, Fang, Pan, Xie, Yang, Zhang, Bai, Cai: "mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis." in: Osteoarthritis and cartilage, Vol. 25, Issue 6, pp. 952-963, (2018) (PubMed).

Wu, Huang, Jiao, Ding, Zhang, Chen, Wang, Li, Huo: "Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells." in: Oncotarget, Vol. 8, Issue 51, pp. 88630-88644, (2017) (PubMed).

Diaz-Flores, Goldschmidt, Depeille, Ng, Akutagawa, Krisman, Crone, Burgess, Williams, Houseman, Shokat, Sampath, Bollag, Roose, Braun, Shannon: "PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras." in: Science signaling, Vol. 6, Issue 304, pp. ra105, (2013) (PubMed).

Liu, Chen, Chau, Jan, Chen, Hsu, Lin, Juang, Lu, Cheng, Chen, Chang, Ting, Kao, Hsiao, Huang: "Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma." in: Molecular & cellular proteomics : MCP, Vol. 12, Issue 5, pp. 1335-49, (2013) (PubMed).

Pan, Dong, Wang, Yang, Zhang, Li, Zhang, Yang, Li, Tan, Wang: "Signal regulatory protein ? negatively regulates mast-cell activation following Fc?RI aggregation." in: European journal of immunology, Vol. 43, Issue 6, pp. 1598-607, (2013) (PubMed).

Guan, Wei, Wu, Fang, Liao, Xiao, Li, Li: "Down-regulation of miR-218-2 and its host gene SLIT3 cooperate to promote invasion and progression of thyroid cancer." in: The Journal of clinical endocrinology and metabolism, Vol. 98, Issue 8, pp. E1334-44, (2013) (PubMed).

Hsieh, Liu, Hsu, Jayakumar, Chou, Wang, Hsiao, Sheu et al.: "Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCgamma1 ..." in: Free radical biology & medicine, Vol. 49, Issue 5, pp. 881-93, (2010) (PubMed).

Moorhead, Jung, Smirnov, Kaufer, Scidmore: "Multiple host proteins that function in phosphatidylinositol-4-phosphate metabolism are recruited to the chlamydial inclusion." in: Infection and immunity, Vol. 78, Issue 5, pp. 1990-2007, (2010) (PubMed).

Shannon, Calloway, Welch, Vines: "CCR7/CCL21 migration on fibronectin is mediated by phospholipase Cgamma1 and ERK1/2 in primary T lymphocytes." in: The Journal of biological chemistry, Vol. 285, Issue 50, pp. 38781-7, (2010) (PubMed).

Synonyms and alternative names related to Phospholipase C gamma 1

phospholipase C gamma 1 (PLCG1), phospholipase C gamma 1 L homeolog (plcg1.L), 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (LOC100633163), phospholipase C, gamma 1 (Plcg1), phospholipase C gamma 1 (Plcg1), phospholipase C, gamma 1 (plcg1), AI894140, Cded, fj46f04, NCKAP3, nckap3, Plc-1, Plc-gamma1, PLC-II, plc-ii, PLC1, plc1, PLC148, plc148, Plcg-1, PLCgamma1, plcgamma1, PPLCA, wu:fj46f04, wu:fj57a05

Protein level used designations for Phospholipase C gamma 1

  • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
  • 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
  • PLC-148
  • PLC-gamma-1
  • inositoltrisphosphohydrolase
  • monophosphatidylinositol phosphodiesterase
  • phosphatidylinositol phospholipase C
  • phosphoinositidase C
  • phosphoinositide phospholipase C
  • phosphoinositide phospholipase C-gamma-1
  • phospholipase C, gamma 1 (formerly subtype 148)
  • phospholipase C-148
  • phospholipase C-II
  • phospholipase C-gamma-1
  • triphosphoinositide phosphodiesterase
  • PLC gamma 1
  • phospholipase C-gamma-1b
  • phospholipase C, gamma 1
  • PLC-II
  • cell differentiation and embryonic development
  • dead beat
  • ded
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