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anti-Human Phospholipase D2 Antibodies:
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Human Polyclonal Phospholipase D2 Primary Antibody for EIA, IHC (p) - ABIN954193
Chae, Kim, Ha, Kim, Suh, Ryu: Protein kinase Cdelta-mediated phosphorylation of phospholipase D controls integrin-mediated cell spreading. in Molecular and cellular biology 2010
Show all 4 references for ABIN954193
Human Monoclonal Phospholipase D2 Primary Antibody for ELISA, WB - ABIN562269
Somers-Edgar, Taurin, Larsen, Chandramouli, Nelson, Rosengren: Mechanisms for the activity of heterocyclic cyclohexanone curcumin derivatives in estrogen receptor negative human breast cancer cell lines. in Investigational new drugs 2011
Cow (Bovine) Polyclonal Phospholipase D2 Primary Antibody for WB - ABIN2777719
Gorshkova, He, Berdyshev, Usatuyk, Burns, Kalari, Zhao, Pendyala, Garcia, Pyne, Brindley, Natarajan: Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1. in The Journal of biological chemistry 2008
Human Monoclonal Phospholipase D2 Primary Antibody for ELISA, WB - ABIN393480
Oguin, Sharma, Stuart, Duan, Scott, Jones, Daniels, Lindsley, Thomas, Brown: Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition. in The Journal of biological chemistry 2014
PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells.
PLD2 protein itself interacts with HIF-1alpha (show HIF1A Antibodies), prolyl hydroxylase (PHD (show PDC Antibodies)) and VHL (show VHL Antibodies) to promote degradation of HIF-1alpha (show HIF1A Antibodies) via the proteasomal pathway independent of lipase (show LIPG Antibodies) activity.
PLD2-mediated production of phosphatidic acid contributed to the control of EGFR (show EGFR Antibodies) exposure to ligand through a multipronged transcriptional and posttranscriptional program during the out-of-control accumulation of EGFR (show EGFR Antibodies) signaling in cancer cells.
These results suggest that PLD2 expression in colon cancer cells is up-regulated via HIF1-alpha (show HIF1A Antibodies) in response to hypoxic stress and underscores the crucial role of HIF1-alpha (show HIF1A Antibodies)-induced PLD2 in tumor growth.
A 3D model of the PLD2 by combining homology and ab initio 3 dimensional structural modeling methods, and docking conformation, is reported.
PLD2 expression regulates formation of Golgi tubules in Hela cells.
Results indicate distinctive roles of phospholipase D PLD1 (show PLD Antibodies) and PLD2 isoforms in pathological conditions in retinal pigment epithelium (RPE (show RPE Antibodies)).
Phospholipase D is involved in the formation of Golgi associated clathrin coated vesicles in human parotid duct cells
PLD2, but not PLD1, directly binds to the C terminus of TREK1 (show KCNK2 Antibodies) and TREK2 (show KCNK10 Antibodies).
Ectopic expression of PLD1 or PLD2 in human glioma U87 cells increased the expression of hypoxia-inducible factor-1alpha protein.
Results suggest that PLD2 is the isoform that mediates aldosterone secretion and likely priming.
PLD1/2 signaling pathways are involved in mitogenic signaling in astrocytes.
Data show that although phospholipase D PLD1 (show PLD Antibodies) deficiency impaired Fc epsilon receptor FcepsilonRI (show FCER1A Antibodies)-mediated signaling and mast cell function, phospholipase D (show PLD Antibodies) PLD2 deficiency actually enhanced these pathways.
PLD2 in neutrophils is essential for the pathogenesis of experimental sepsis
The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD (show PLD Antibodies)) trafficking and activity in mast cells was investigated.
AQP3 (show AQP3 Antibodies) has a pro-differentiative role in epidermal keratinocytes and PLD2 activity is necessary for this effect.
phosphatidic acid and phospholipase D1 and D2 have roles in leukocyte adhesion
PLD1 and PLD2 have roles in platelet alpha-granule secretion
Demonstrate a novel role for endothelial PLD2 in the survival and migration of ECs under hypoxia via the expression of hypoxia-inducible factor-1alpha and in pathological retinal angiogenesis and tumor angiogenesis in vivo.
Pharmacological PLD (show PLD Antibodies) inhibition might provide a safe therapeutic strategy to prevent arterial thrombosis and ischemic stroke.
The results indicate that PKC (show FYN Antibodies) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase (show DNAH8 Antibodies) by Ang II (show AGT Antibodies).
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.
, phospholipase D2-like
, choline phosphatase 2
, phosphatidylcholine-hydrolyzing phospholipase D2
, PLD 2
, phospholipase D gene 2