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anti-Human Phospholipase D2 Antibodies:
anti-Rat (Rattus) Phospholipase D2 Antibodies:
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Human Monoclonal Phospholipase D2 Primary Antibody for ELISA, WB - ABIN393480
Oguin, Sharma, Stuart, Duan, Scott, Jones, Daniels, Lindsley, Thomas, Brown: Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition. in The Journal of biological chemistry 2014
Human Monoclonal Phospholipase D2 Primary Antibody for ELISA, WB - ABIN562269
Somers-Edgar, Taurin, Larsen, Chandramouli, Nelson, Rosengren: Mechanisms for the activity of heterocyclic cyclohexanone curcumin derivatives in estrogen receptor negative human breast cancer cell lines. in Investigational new drugs 2011
PLD2 is involved into pathogenesis of a vast array of human diseases, and as such it can be targeted for therapy. (Review)
Slug is a positive regulator, and Snail (show SNAI1 Antibodies) a negative regulator, of PLD2 expression.
Data suggest that elevated membrane tension acts through phospholipase D2 (PLD2) and the mammalian target of rapamycin (show FRAP1 Antibodies) complex 2 (mTORC2 (show CRTC2 Antibodies)) to limit actin nucleation.
results suggest that the small GTPase (show RACGAP1 Antibodies) RalA (show rala Antibodies) plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (show CAV1 Antibodies) and FilA but by stimulating PLD2-mediated generation of phosphatidic acid.
Suggest PLD (show PLD Antibodies) expression in high grade serous ovarian carcinoma may have a role in mediating progression to effusions and chemoresistance.
PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells.
PLD2 protein itself interacts with HIF-1alpha (show HIF1A Antibodies), prolyl hydroxylase (PHD (show PDC Antibodies)) and VHL (show VHL Antibodies) to promote degradation of HIF-1alpha (show HIF1A Antibodies) via the proteasomal pathway independent of lipase (show LIPG Antibodies) activity.
PLD2-mediated production of phosphatidic acid contributed to the control of EGFR (show EGFR Antibodies) exposure to ligand through a multipronged transcriptional and posttranscriptional program during the out-of-control accumulation of EGFR (show EGFR Antibodies) signaling in cancer cells.
These results suggest that PLD2 expression in colon cancer cells is up-regulated via HIF1-alpha (show HIF1A Antibodies) in response to hypoxic stress and underscores the crucial role of HIF1-alpha (show HIF1A Antibodies)-induced PLD2 in tumor growth.
A 3D model of the PLD2 by combining homology and ab initio 3 dimensional structural modeling methods, and docking conformation, is reported.
Results suggest that PLD2 is the isoform that mediates aldosterone secretion and likely priming.
High PLD2 expression is associated with Lung Metastasis of Breast Cancer.
Pld1-/- and Pld2-/- mice present elevated free fatty acids (FFA) levels and are insulin (show INS Antibodies) as well as glucose intolerant. In conclusion, these data suggest that deficiency of PLD1 or PLD2 activity promotes development of overweight and diabetes.
PLD1/2 signaling pathways are involved in mitogenic signaling in astrocytes.
Data show that although phospholipase D PLD1 (show PLD Antibodies) deficiency impaired Fc epsilon receptor FcepsilonRI (show FCER1A Antibodies)-mediated signaling and mast cell function, phospholipase D (show PLD Antibodies) PLD2 deficiency actually enhanced these pathways.
PLD2 in neutrophils is essential for the pathogenesis of experimental sepsis
The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD (show PLD Antibodies)) trafficking and activity in mast cells was investigated.
AQP3 (show AQP3 Antibodies) has a pro-differentiative role in epidermal keratinocytes and PLD2 activity is necessary for this effect.
phosphatidic acid and phospholipase D1 and D2 have roles in leukocyte adhesion
PLD1 and PLD2 have roles in platelet alpha-granule secretion
The results indicate that PKC (show FYN Antibodies) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase (show DNAH8 Antibodies) by Ang II (show AGT Antibodies).
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.
, phospholipase D2-like
, choline phosphatase 2
, phosphatidylcholine-hydrolyzing phospholipase D2
, PLD 2
, phospholipase D gene 2