Browse our Ret Proto-Oncogene Proteins (RET)

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Ret Proto-Oncogene Proteins (RET)
On are 38 Ret Proto-Oncogene (RET) Proteins from 7 different suppliers available. Additionally we are shipping Ret Proto-Oncogene Antibodies (391) and Ret Proto-Oncogene Kits (19) and many more products for this protein. A total of 468 Ret Proto-Oncogene products are currently listed.
c-Ret, CDHF12, CDHR16, cret, etID315074.13, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET, ret-A, RET-ELE1, ret1, RET9, RET51, wu:fd13h01, X-ret, xret
list all proteins Gene Name GeneID UniProt
RET 5979 P07949
RET 19713 P35546
Rat RET RET 24716  

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Ret Proto-Oncogene Proteins (RET) by Origin

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Top referenced Ret Proto-Oncogene Proteins

  1. Human Ret Proto-Oncogene Protein expressed in Baculovirus infected Insect Cells - ABIN2004970 : Kawamoto, Takeda, Okuno, Yamakawa, Ito, Taguchi, Kato, Suzuki, Takahashi, Nakashima: Identification of RET autophosphorylation sites by mass spectrometry. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 2004970

  2. Human Ret Proto-Oncogene Protein expressed in Human Cells - ABIN2004968 : Saenko, Rogounovitch, Shimizu-Yoshida, Abrosimov, Lushnikov, Roumiantsev, Matsumoto, Nakashima, Meirmanov, Ohtsuru, Namba, Tsyb, Yamashita: Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient. in Mutation research 2003 (PubMed)
    Show all 5 references for 2004968

More Proteins for Ret Proto-Oncogene Interaction Partners

Zebrafish Ret Proto-Oncogene (RET) interaction partners

  1. These data provide the first evidence for a physiologic role of these isoforms in RET pathway function.

  2. Significantly, we show that introduction of mapk10 (show MAPK10 Proteins) mutations into ret heterozygotes enhanced the ENS deficit, supporting MAPK10 (show MAPK10 Proteins) as a Hirschsprung disease (HSCR (show EDNRB Proteins)) susceptibility locus. Our studies demonstrate that ret heterozygous zebrafish is a sensitized model, with many significant advantages over existing murine models, to explore the pathophysiology and complex genetics of HSCR (show EDNRB Proteins).

  3. RET expression is investigated within the brain of zebrafish; both RET protein and mRNA are observed.

  4. In animals lacking Ret or Gfra3 (show GFRA3 Proteins) function, myogenic gene expression is reduced in forming opercular muscles, but not in non-opercular muscles derived from the same muscle anlagen.

  5. evaluation of noncoding sequences at the zebrafish ret locus conserved among teleosts, and at the human RET locus, conserved among mammals

  6. genes beyond RET may be implicated in the genesis of sporadic cases of HD

Human Ret Proto-Oncogene (RET) interaction partners

  1. Patients with high- and moderate-risk RET mutations had similar OS and development of distant metastatic disease after medullary thyroid carcinoma diagnosis and therefore similarly aggressive clinical courses. High-risk connotes increased disease aggressiveness; thus, future guidelines should consider RET mutation classification by disease onset (early vs late) rather than by risk (high vs moderate).

  2. results contradict previous studies suggesting that mammalian GFRalpha1 (show GFRA1 PLURAL_@32801@) and GDNF (show GDNF PLURAL_@32801@) cannot bind and activate non-mammalian RET and vice versa

  3. the significant increase of blunt-ended, double-stranded DNA breaks, but not other types of DNA breaks, in normal cells from patients with RET/PTC-driven tumors suggests that blunt-ended double-stranded DNA breaks are a preferred substrate for rearrangement formation, and implicate involvement of the non-homologous end joining pathway in the formation of RET/PTC rearrangements.

  4. Up-regulation of RET expression is associated with medullary thyroid carcinoma.

  5. Eight rare RET-coding variants, one possible splice-site variant were identified in patients with Hirschsprung disease. Almost half of the identified rare variants are proven pathogenic in vitro.

  6. We also demonstrate that the effects of RET and NRG1 (show NRG1 Proteins) are universal across European and Asian ancestries. In contrast, we detected a European-specific association of a low-frequency variant, rs80227144, in SEMA3. Conditional analyses on the lead SNPs revealed a secondary association signal, corresponding to an Asian-specific, low-frequency missense variant encoding RET p.Asp489Asn

  7. RET plays a role in mediating the phosphorylation of EGFR (show EGFR Proteins) in head and neck squamous cell carcinoma. RET inhibition not only decreases tumor growth but also enhances the efficacy of EGFR (show EGFR Proteins) inhibition with erlotinib treatment.

  8. Study identified TP53 (show TP53 Proteins) and RET among the most mutated oncogenes in hepatocellular carcinoma to be associated with lower overall survival.

  9. A p.C634W mutation in ret proto-oncogene protein (RET) has been detected in a family affected with multiple endocrine neoplasia type 2A (MEN2A), in which most carriers have developed clinical symptoms.

  10. RET/papillary thyroid cancer (PTC (show F9 Proteins)) rearrangements, resulting in aberrant activity of the RET protein tyrosine kinase (show EPHA8 Proteins) receptor (show NTRK1 Proteins), occur exclusively in papillary thyroid cancer. Serum thyroid stimulating hormone in RET/PTC-positive thyroid cancer patients without nodular goiter or Hashimoto's thyroiditis increased following surgery.

Mouse (Murine) Ret Proto-Oncogene (RET) interaction partners

  1. Using an organ culture system for prostate development and Ret mutant mice, we demonstrate that RET-mediated GDNF (show GDNF PLURAL_@32801@) signaling in UGS increases proliferation of mesenchyme cells and suppresses androgen-induced proliferation and differentiation of prostate epithelial cells, inhibiting prostate development.

  2. we described a RET-ER81 (show ETV1 Proteins)-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ

  3. These data provide the first evidence for a physiologic role of these isoforms in RET pathway function.

  4. Hox (show MSH2 Proteins) proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes.

  5. Ret and Gfra2 (show GFRA2 Proteins) null mice display comparable early central projection deficits, but Gfra2 (show GFRA2 Proteins) null rapidly adapting mechanoreceptors recover later.

  6. Parkin (show PARK2 Proteins) and the RET signaling cascade converge to control mitochondrial integrity and thereby properly maintain substantia nigra pars (show EPRS Proteins) compacta dopaminergic neurons and their innervation in the striatum.

  7. the Ret signaling pathway is important for podocyte survival and recovery from glomerular injury in vivo

  8. RET coupling to ERK (show EPHB2 Proteins) and Akt (show AKT1 Proteins) depends strongly on artemin (show ARTN Proteins) concentration, and it is highest at the low (~100 pM) artemin (show ARTN Proteins) levels required for neurite outgrowth.

  9. we analysed non-thermal, atmospheric pressure, plasma irradiation mediated effects in melanocytic tumors which spontaneously developed in HL-RET-mice

  10. the important IL-10 (show IL10 Proteins) transcription factor Maf (show MAF Proteins) was upregulated in RET-deficient Th2 cells and down-regulated upon RET signalling activation by glial-derived neurotrophic factor (show NTF3 Proteins) family ligands.

Ret Proto-Oncogene (RET) Protein Profile

Protein Summary

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Alternative names and synonyms associated with Ret Proto-Oncogene (RET)

  • ret proto-oncogene receptor tyrosine kinase (ret)
  • ret proto-oncogene (ret)
  • ret proto-oncogene (RET)
  • ret proto-oncogene (Ret)
  • c-Ret protein
  • CDHF12 protein
  • CDHR16 protein
  • cret protein
  • etID315074.13 protein
  • HSCR1 protein
  • MEN2A protein
  • MEN2B protein
  • MTC1 protein
  • PTC protein
  • RET protein
  • ret-A protein
  • RET-ELE1 protein
  • ret1 protein
  • RET9 protein
  • RET51 protein
  • wu:fd13h01 protein
  • X-ret protein
  • xret protein

Protein level used designations for Ret Proto-Oncogene Proteins (RET)

proto-oncogene tyrosine-protein kinase receptor Ret , receptor tyrosine kinase , ret proto-oncogene , tryptase , proto-oncogene tyrosine-protein kinase receptor Ret-like , RET transforming sequence , cadherin family member 12 , cadherin-related family member 16 , hydroxyaryl-protein kinase , proto-oncogene c-Ret , ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) , Ret gene for receptor tyrosin , Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease) , ret tyrosine kinase

30512 Danio rerio
373625 Xenopus laevis
449594 Pan troglodytes
703466 Macaca mulatta
100033966 Equus caballus
100403596 Callithrix jacchus
100442682 Pongo abelii
100467317 Ailuropoda melanoleuca
100495902 Xenopus (Silurana) tropicalis
100602103 Nomascus leucogenys
5979 Homo sapiens
19713 Mus musculus
24716 Rattus norvegicus
403494 Canis lupus familiaris
396107 Gallus gallus
515924 Bos taurus
100340710 Oryctolagus cuniculus
100733392 Cavia porcellus
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