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Browse our Ret Proto-Oncogene Proteins (RET)

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Ret Proto-Oncogene Proteins (RET)
On are 31 Ret Proto-Oncogene (RET) Proteins from 6 different suppliers available. Additionally we are shipping Ret Proto-Oncogene Antibodies (372) and Ret Proto-Oncogene Kits (16) and many more products for this protein. A total of 439 Ret Proto-Oncogene products are currently listed.
c-Ret, CDHF12, CDHR16, cret, etID315074.13, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET, ret-A, RET-ELE1, ret1, RET9, RET51, wu:fd13h01, X-ret, xret
list all proteins Gene Name GeneID UniProt
RET 5979 P07949
RET 19713 P35546
Rat RET RET 24716  

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Ret Proto-Oncogene Proteins (RET) by Origin

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Top referenced Ret Proto-Oncogene Proteins

  1. Human Ret Proto-Oncogene Protein expressed in Baculovirus infected Insect Cells - ABIN2004970 : Kawamoto, Takeda, Okuno, Yamakawa, Ito, Taguchi, Kato, Suzuki, Takahashi, Nakashima: Identification of RET autophosphorylation sites by mass spectrometry. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for ABIN2004970

  2. Human Ret Proto-Oncogene Protein expressed in Human Cells - ABIN2004968 : Saenko, Rogounovitch, Shimizu-Yoshida, Abrosimov, Lushnikov, Roumiantsev, Matsumoto, Nakashima, Meirmanov, Ohtsuru, Namba, Tsyb, Yamashita: Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient. in Mutation research 2003 (PubMed)
    Show all 5 references for ABIN2004968

More Proteins for Ret Proto-Oncogene Interaction Partners

Zebrafish Ret Proto-Oncogene (RET) interaction partners

  1. RET expression is investigated within the brain of zebrafish; both RET protein and mRNA are observed.

  2. In animals lacking Ret or Gfra3 (show GFRA3 Proteins) function, myogenic gene expression is reduced in forming opercular muscles, but not in non-opercular muscles derived from the same muscle anlagen.

  3. evaluation of noncoding sequences at the zebrafish ret locus conserved among teleosts, and at the human RET locus, conserved among mammals

  4. genes beyond RET may be implicated in the genesis of sporadic cases of HD

Human Ret Proto-Oncogene (RET) interaction partners

  1. RET c.1296A may be a common susceptibility allele for nephron underdosing-related diseases. The 5'-UTR and intronic variants near exon 5 of GFRA1 (show GFRA1 Proteins) are not associated with nephron endowment.

  2. Analysis of RET(E616Q) reveals a gain of function mutant phenotype for this variant, in a family with features of Multiple Endocrine Neoplasia Type 2A, which has not previously been reported

  3. Different mutations in the RET gene were identified in Chinese families with multiple endocrine neoplasia type 2A : C634S in Family 1, C611Y in Family 2, and C634Y in Family 3

  4. This study shows that the Cys634Tyr missense substitution and the Gly691Ser polymorphism are recurrent in three unrelated families with MEN2A.

  5. RET proto-oncogene mutation is associated with Hereditary Medullary Thyroid Carcinoma.

  6. Our findings nevertheless suggest that CCDC6 (show CCDC6 Proteins)-RET fusions identified by multiplex testing are potential targets for nintedanib therapy.

  7. our study suggested that the prevalence of ALK, ROS1 (show ROS1 Proteins) and RET fusions is very rare in lung squamous cell carcinoma patients.

  8. Data show that heat shock protein 90 (HSP90 (show HSP90 Proteins)) inhibitor 17-DMAG caused loss of ret proto-oncogene protein (RET) and proto-oncogene (show RAB1A Proteins) protein erbB-3 (ERBB3 (show ERBB3 Proteins)) phosphorylation and lead to rapid cell death.

  9. Results suggest, a potential role for PIK3CA (show PIK3CA Proteins), VEGFR2 (show KDR Proteins), RET and FGFR2 (show FGFR2 Proteins) as therapeutic targets in EGFR (show EGFR Proteins) non-mutated NSCLC that requires further clinical validation.

  10. Study shows that the RET nuclear expression was an independent predictor of renal clear cell carcinoma postoperative metastasis.

Mouse (Murine) Ret Proto-Oncogene (RET) interaction partners

  1. Hox (show MSH2 Proteins) proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes.

  2. Ret and Gfra2 (show GFRA2 Proteins) null mice display comparable early central projection deficits, but Gfra2 (show GFRA2 Proteins) null rapidly adapting mechanoreceptors recover later.

  3. Parkin (show PARK2 Proteins) and the RET signaling cascade converge to control mitochondrial integrity and thereby properly maintain substantia nigra pars (show EPRS Proteins) compacta dopaminergic neurons and their innervation in the striatum.

  4. the Ret signaling pathway is important for podocyte survival and recovery from glomerular injury in vivo

  5. RET coupling to ERK (show EPHB2 Proteins) and Akt (show AKT1 Proteins) depends strongly on artemin (show ARTN Proteins) concentration, and it is highest at the low (~100 pM) artemin (show ARTN Proteins) levels required for neurite outgrowth.

  6. we analysed non-thermal, atmospheric pressure, plasma irradiation mediated effects in melanocytic tumors which spontaneously developed in HL-RET-mice

  7. the important IL-10 (show IL10 Proteins) transcription factor Maf (show MAF Proteins) was upregulated in RET-deficient Th2 cells and down-regulated upon RET signalling activation by glial-derived neurotrophic factor (show NTF3 Proteins) family ligands.

  8. the neurotrophic factor (show NTF3 Proteins) receptor RET drives haematopoietic stem cell survival, expansion and function; haematopoietic stem cells express RET and its neurotrophic factor (show NTF3 Proteins) partners are produced in the haematopoietic stem cell environment

  9. TNFR1 (show TNFRSF1A Proteins) exerts a dual role in nociceptor information processing by suppressing TrkA (show NTRK1 Proteins) and enhancing Ret signaling in peptidergic and nonpeptidergic nociceptors, respectively.

  10. only the SH3 domains of CD2AP (show Cd2ap Proteins) are necessary to enhance the E3 ligase activity of Cbl-3 (show CBLC Proteins)/c toward Ret51

Ret Proto-Oncogene (RET) Protein Profile

Protein Summary

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Alternative names and synonyms associated with Ret Proto-Oncogene (RET)

  • ret proto-oncogene receptor tyrosine kinase (ret)
  • ret proto-oncogene (ret)
  • ret proto-oncogene (RET)
  • ret proto-oncogene (Ret)
  • c-Ret protein
  • CDHF12 protein
  • CDHR16 protein
  • cret protein
  • etID315074.13 protein
  • HSCR1 protein
  • MEN2A protein
  • MEN2B protein
  • MTC1 protein
  • PTC protein
  • RET protein
  • ret-A protein
  • RET-ELE1 protein
  • ret1 protein
  • RET9 protein
  • RET51 protein
  • wu:fd13h01 protein
  • X-ret protein
  • xret protein

Protein level used designations for Ret Proto-Oncogene Proteins (RET)

proto-oncogene tyrosine-protein kinase receptor Ret , receptor tyrosine kinase , ret proto-oncogene , tryptase , proto-oncogene tyrosine-protein kinase receptor Ret-like , RET transforming sequence , cadherin family member 12 , cadherin-related family member 16 , hydroxyaryl-protein kinase , proto-oncogene c-Ret , ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) , Ret gene for receptor tyrosin , Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease) , ret tyrosine kinase

30512 Danio rerio
373625 Xenopus laevis
449594 Pan troglodytes
703466 Macaca mulatta
100033966 Equus caballus
100403596 Callithrix jacchus
100442682 Pongo abelii
100467317 Ailuropoda melanoleuca
100495902 Xenopus (Silurana) tropicalis
100602103 Nomascus leucogenys
5979 Homo sapiens
19713 Mus musculus
24716 Rattus norvegicus
403494 Canis lupus familiaris
396107 Gallus gallus
515924 Bos taurus
100340710 Oryctolagus cuniculus
100733392 Cavia porcellus
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