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Browse our TRKA Proteins (NTRK1)

Full name:
Neurotrophic Tyrosine Kinase, Receptor, Type 1 Proteins (NTRK1)
On are 24 Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) Proteins from 7 different suppliers available. Additionally we are shipping TRKA Antibodies (402) and TRKA Kits (32) and many more products for this protein. A total of 482 TRKA products are currently listed.
C80751, CAPM1, CFTD, CTRKA, hscp30, MTC, NEM1, OK/SW-cl.5, p140-TrkA, Tkr, TM-5, TM3, TM5, TM30, TM30nm, TPMsk3, Trk, Trk-A, TRK1, trkA
list all proteins Gene Name GeneID UniProt
NTRK1 4914 P04629
NTRK1 18211 Q3UFB7
NTRK1 59109 P35739

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TRKA Proteins (NTRK1) by Origin

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Top referenced TRKA Proteins

  1. Dog (Canine) TRKA Protein expressed in Human Cells - ABIN2008971 : Bossemeyer, Borchard, Dosch, Helmer, Epstein, Booth, Bakker: K+-transport protein TrkA of Escherichia coli is a peripheral membrane protein that requires other trk gene products for attachment to the cytoplasmic membrane. in The Journal of biological chemistry 1989 (PubMed)
    Show all 5 references for ABIN2008971

  2. Human TRKA Protein expressed in Escherichia coli (E. coli) - ABIN2003907 : Varsano, Dong, Niesman, Gacula, Lou, Ma, Testa, Yates, Farquhar: GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling. in Molecular and cellular biology 2006 (PubMed)
    Show all 5 references for ABIN2003907

  3. Mouse (Murine) TRKA Protein expressed in Human Cells - ABIN2008616 : Perrone, Paladino, Mazzone, Nitsch, Gulisano, Zurzolo: Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling. in The Biochemical journal 2004 (PubMed)
    Show all 5 references for ABIN2008616

  4. Human TRKA Protein expressed in Human Cells - ABIN2003911 : Holtzman, Kilbridge, Li, Cunningham, Lenn, Clary, Reichardt, Mobley: TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 (PubMed)
    Show all 5 references for ABIN2003911

  5. Rat (Rattus) TRKA Protein expressed in Human Cells - ABIN2009588 : Lin, Quevedo, Brewer, Bell, Testa, Grimes, Miller, Kaplan: APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. in Molecular and cellular biology 2006 (PubMed)
    Show all 5 references for ABIN2009588

More Proteins for TRKA Interaction Partners

Zebrafish Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) interaction partners

  1. TrkA-like immunoreactivity was the only Trk detected, and it was restricted to the somata of crypt sensory neurons, their central processes being apparently unreactive.

Rabbit Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) interaction partners

  1. report describing differential expression of proteins and mRNA for NGF (show NGFB Proteins) and its cognate receptors, NTRK1 and NGFR (show NGFR Proteins), in the male sex organs of rabbits

Human Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) interaction partners

  1. Dominant mutations in TPM3 (show TPM3 Proteins), encoding alpha-tropomyosinslow, cause a congenital myopathy characterized by generalized muscle weakness. Here, we used a multidisciplinary approach to investigate the mechanism of muscle dysfunction in 12 TPM3 (show TPM3 Proteins)-myopathy patients.

  2. Two key biological processes for progressive hearing loss, TrkA signaling pathway and EGF receptor (show EGFR Proteins) signaling pathway were significantly and differentially enriched by the two sets of allele-specific target genes of miR (show MLXIP Proteins)-96.

  3. Report novel variant of myo/haemangiopericytic sarcoma with recurrent NTRK1 gene fusions.

  4. TrkA as a candidate oncogene (show RAB1A Proteins) in malignant melanoma and support a model in which the NGF (show NGFB Proteins)-TrkA-MAPK (show MAPK1 Proteins) pathway may mediate a trade-off between neoplastic transformation and adaptive anti-proliferative response.

  5. NGF (show NGFB Proteins) has a role in modulating trkANGFR/p75NTR (show NGFR Proteins) in alphaSMA (show ACTA2 Proteins)-expressing conjunctival fibroblasts from human ocular cicatricial pemphigoid

  6. This work expands the phenotypic spectrum of TPM3 (show TPM3 Proteins)-related disease and provides insights into the pathophysiological mechanisms of the actin-tropomyosin (show TPM2 Proteins) complex

  7. NGF (show NGFB Proteins)-induced tyrosine kinase (show TXK Proteins) independent TrkA signaling through CD44 (show CD44 Proteins) is sufficient to maintain tumor aggressiveness in breast cancer

  8. IL-13 (show IL13 Proteins) confers epithelial cell responsiveness to NGF (show NGFB Proteins) by regulating NTRK1 levels by a transcriptional and epigenetic mechanism and that this process likely contributes to allergic inflammation.

  9. NGF (show NGFB Proteins) and its precursor proNGF are primarily considered as regulators of neuronal function that induce their responses via the tyrosine kinase receptor TrkA and the panneurotrophin receptor p75NTR (show NGFR Proteins). (Review)

  10. findings suggest that Cbl-b limits NGF (show NGFB Proteins)-TrkA signaling to control the length of neurites.

Mouse (Murine) Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) interaction partners

  1. Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.

  2. Data show that lysophosphatidic acid (LPA) induces phosphorylation of trkA receptor (TrkA) through lysophosphatidic acid receptor 1 (LPA1 (show LPAR1 Proteins)) binding to TrkA

  3. adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk mouse mutant with a pain phenotype

  4. IL-6 (show IL6 Proteins) may act as a new potential cumulus expansion-related transcript, which may be involved in the integration of TrkA and EGF (show EGF Proteins) signaling in affecting expansion of cumulus oocyte complexes.

  5. SOCS2 (show SOCS2 Proteins) immunoprecipitates with TrkA and a juxtamembrane motif of TrkA is required for this interaction. Over-expression of SOCS2 (show SOCS2 Proteins) in PC12 Tet-On cells increased total and surface TrkA expression.

  6. the ubiquitination of the TrkA neurotrophin receptor plays a critical role in NGF-mediated functions, such as neuronal survival and sensitivity to pain.

  7. These data suggest that ubiquitination is a mechanism used in nociceptive neurons to regulate TrkA level and function.

  8. the juxtamembrane region of p75(ICD (show NGFR Proteins)) acts to cause a conformational change within the extracellular domain of TrkA.

  9. Our results suggest that BDNF (show BDNF Proteins)-TrkB (show NTRK2 Proteins) but not NGF (show NGFB Proteins)-TrkA signaling is involved in the brain repair after ICH (show ACE Proteins), and early proper treadmill exercise might promote this repair process.

  10. NGF support the survival of only a subset of basal forebrain cholinergic neuron during brain development.

TRKA (NTRK1) Protein Profile

Protein Summary

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TRKA (NTRK1)

  • neurotrophic tyrosine kinase, receptor, type 1 (ntrk1)
  • neurotrophic tyrosine kinase, receptor, type 1 (NTRK1)
  • neurotrophic tyrosine kinase, receptor, type 1 (LOC100354292)
  • neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1)
  • tropomyosin 3 (TPM3)
  • C80751 protein
  • CAPM1 protein
  • CFTD protein
  • CTRKA protein
  • hscp30 protein
  • MTC protein
  • NEM1 protein
  • OK/SW-cl.5 protein
  • p140-TrkA protein
  • Tkr protein
  • TM-5 protein
  • TM3 protein
  • TM5 protein
  • TM30 protein
  • TM30nm protein
  • TPMsk3 protein
  • Trk protein
  • Trk-A protein
  • TRK1 protein
  • trkA protein

Protein level used designations for NTRK1

high affinity nerve growth factor receptor , tyrosine kinase receptor A , neurotrophic tyrosine kinase, receptor, type 1 , high affinity nerve growth factor receptor-like , tropomyosin-related kinase A , Oncogene TRK , TRK1-transforming tyrosine kinase protein , gp140trk , TrkA neurotrophin receptor , p140-TrkA , slow nerve growth factor receptor , trk , trk-A , trkA proto-oncogene receptor , neurotrophic tyrosine kinase receptor type 1 , tropomyosin receptor kinase , alpha-tropomyosin, slow skeletal , cytoskeletal tropomyosin TM30 , heat-stable cytoskeletal protein 30 kDa , tropomyosin alpha-3 chain , tropomyosin gamma , tropomyosin-5

30546 Danio rerio
719670 Macaca mulatta
100064594 Equus caballus
100452269 Pongo abelii
100474165 Ailuropoda melanoleuca
457408 Pan troglodytes
490404 Canis lupus familiaris
100354292 Oryctolagus cuniculus
100585466 Nomascus leucogenys
100618744 Monodelphis domestica
4914 Homo sapiens
18211 Mus musculus
59109 Rattus norvegicus
353111 Bos taurus
396337 Gallus gallus
7170 Homo sapiens
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