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Browse our TSC1 Proteins (TSC1)

Full name:
Tuberous Sclerosis 1 Proteins (TSC1)
On www.antibodies-online.com are 3 Tuberous Sclerosis 1 (TSC1) Proteins from 2 different suppliers available. Additionally we are shipping TSC1 Antibodies (810) and TSC1 Kits (2) and many more products for this protein. A total of 832 TSC1 products are currently listed.
Synonyms:
hamartin, LAM, mKIAA0243, TSC, tsc1, wu:fc38b04
list all proteins Gene Name GeneID UniProt
TSC1 7248 Q92574
TSC1 64930 Q9EP53
Rat TSC1 TSC1 60445 Q9Z136

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TSC1 Proteins (TSC1) by Origin

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More Proteins for TSC1 Interaction Partners

Zebrafish Tuberous Sclerosis 1 (TSC1) interaction partners

  1. Tsc1 is involved in regulation of interactive network between the cilium and the TOR pathway.

Human Tuberous Sclerosis 1 (TSC1) interaction partners

  1. The mTOR (show FRAP1 Proteins)-dependent, epithelial phenotype of TSC (show SLC12A3 Proteins) astrocytes suggests TSC1/2 and mTOR (show FRAP1 Proteins) tune the phosphorylation level of catenin delta-1 (show CTNND1 Proteins) by controlling PKCe (show PRKCE Proteins) activity, thereby regulating the mesenchymal-epithelial-transition (MET)

  2. We conditionally ablated the tuberous sclerosis complex 1 (Tsc1) gene, an mTOR (show FRAP1 Proteins) inhibitor, in the rods of the Pde6b (show PDE6B Proteins)(H620Q/H620Q) preclinical RP mouse model and observed, functionally and morphologically, an improvement in the survival of rods and cones at early and late disease stages.

  3. TSC1 mutations leading to tuberous sclerosis in Chinese children.

  4. Our results indicate that TSC2 and less commonly TSC1 alterations are the primary essential driver event in angiomyolipoma/Lymphangioleiomyomatosis, whereas other somatic mutations are rare and likely do not contribute to tumor development.

  5. brain somatic mutations in TSC1 and TSC2 cause focal cortical dysplasia

  6. TSC1 expression is reduced in two subsets of clear-cell renal cell carcinomas, those with monoallelic VHL (show VHL Proteins) gene inactivation and those with concurrent low HIF-1alpha (show HIF1A Proteins) and high HIF-2alpha (show EPAS1 Proteins) expression.

  7. Repression of TSC1/TSC2 mediated by MeCP2 (show MECP2 Proteins) regulates human embryo lung fibroblast cell differentiation and proliferation.

  8. TSC1 mutation is associated in patients, diagnosed with tuberous sclerosis associated vascular malformation.

  9. Novel TSC1 mutations in Chinese patients with tuberous sclerosis.

  10. Gene expression level of TSC1 is significantly higher in AD patients when compared to normal controls.

Mouse (Murine) Tuberous Sclerosis 1 (TSC1) interaction partners

  1. Recombination and loss of Tsc1 was demonstrated in skin fibroblasts in vivo and in cultured skin fibroblasts. Loss of Tsc1 in fibroblasts in mice does not lead to a model of angiomyolipoma or lymphangioleiomyomatosis.

  2. Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A (show FLNA Proteins) levels. Reducing filamin A (FLNA (show FLNA Proteins)) levels has been shown to decrease Tsc1(+/-) dendritic complexity, these data suggest that increased FLNA (show FLNA Proteins) levels in Tsc1(+/-) mice contribute to abnormal dendritic patterning in the Tsc1 heterozygote condition of individuals with tuberous sclerosis complex.

  3. selective mTORC1 activation in smooth muscle cells induced by deleting the negative mTORC1 regulator tuberous sclerosis complex 1 gene (TSC1) was sufficient to produce pulmonary hypertension.

  4. The present study demonstrates for the first time evidence of microglial activation in a mouse model of TSC (show SLC12A3 Proteins) with mutation tsc1.

  5. Repression of TSC1/TSC2 mediated by MeCP2 (show MECP2 Proteins) regulates human embryo lung fibroblast cell differentiation and proliferation.

  6. suppression of AKT (show AKT1 Proteins) by hyperactivation of mTORC1, inhibition on nuclear ERalpha (show ESR1 Proteins) signaling, and down-regulation of cell-cycle-driving proteins play important roles in the retarded mammary development induced by Tsc1 deletion.

  7. TSC1 knockout mice are lean, glucose intolerant with a decreased activation of protein kinase B (Akt/PKB (show AKT1 Proteins)) targets that regulate glucose transporters in skeletal muscle.

  8. a pivotal role for Tsc1 in regulating various aspects of visual-pathway development, is reported.

  9. PAK2 (show PAK2 Proteins) is a direct effector of TSC1-TSC2-RHEB (show RHEB Proteins) signaling and a new target for rational drug therapy in TSC (show SLC12A3 Proteins).

  10. Tsc1 plays a critical role in regulating macrophage survival, function and polarization via inhibition of mTORC1 activity.

TSC1 Protein Profile

Protein Summary

This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with TSC1

  • tuberous sclerosis 1 (TSC1)
  • tuberous sclerosis 1b (tsc1b)
  • tuberous sclerosis 1 (tsc1)
  • tuberous sclerosis 1 (Tsc1)
  • hamartin protein
  • LAM protein
  • mKIAA0243 protein
  • TSC protein
  • tsc1 protein
  • wu:fc38b04 protein

Protein level used designations for Tuberous Sclerosis 1 Proteins (TSC1)

tuberous sclerosis 1 protein , tuberous sclerosis 1 , fc38b04 , hamartin , hamartin-like , tumor suppressor , tuberous sclerosis 1 protein homolog , chromosome 9 TSC1

GENE ID SPECIES
100066615 Equus caballus
464818 Pan troglodytes
100017591 Monodelphis domestica
100080641 Ornithorhynchus anatinus
100330617 Danio rerio
100338695 Oryctolagus cuniculus
100380126 Xenopus (Silurana) tropicalis
100407741 Callithrix jacchus
100471530 Ailuropoda melanoleuca
100539473 Meleagris gallopavo
100587112 Nomascus leucogenys
7248 Homo sapiens
64930 Mus musculus
60445 Rattus norvegicus
480688 Canis lupus familiaris
100154726 Sus scrofa
533440 Bos taurus
417166 Gallus gallus
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