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Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 and Mer (show MERTK ELISA Kits) expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 and Mer (show MERTK ELISA Kits) mRNA and increased shedding of sTyro3 and sMer.
TYRO3 is overexpressed in the early stage of colon cancer development and aberrant expression of TYRO3 promotes tumorigenesis and induces EMT (show ITK ELISA Kits) through the regulation of SNAI1 (show SNAI1 ELISA Kits).
In this paper, we review the biology of the Gas6 (show GAS6 ELISA Kits)/Tyro3, Axl (show AXL ELISA Kits), and MerTK (show MERTK ELISA Kits)(collectively named TAM (show CCNA1 ELISA Kits) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
these data suggest that Tyro3 contributes significantly to tumor growth, aggressiveness and liver dysfunction
Tyro3 gene dosage modulates Mertk (show MERTK ELISA Kits)-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 in RPE phagocytosis, and suggest that an eQTL (show EQTN ELISA Kits) can modify a recessive Inherited photoreceptor degenerations.
The mRNA expression levels of Tyro-3, Axl (show AXL ELISA Kits) were decreased in pSS (show CDSN ELISA Kits) patients. When considering the plasma level, increased levels of soluble Mer (show MERTK ELISA Kits) was observed with statistically significant difference.
genetic ablation of a receptor tyrosine kinase (show RET ELISA Kits) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
the results of the present study demonstrated that the acquired taxol resistance of ovarian cancer cells was associated with ROS (show ROS1 ELISA Kits)-dependent upregulation in the expression of Tyro3 RTK and the subsequent activation of Akt (show AKT1 ELISA Kits).
Tetherin (show BST2 ELISA Kits) phosphorylation induces the recruitment of Syk (show SYK ELISA Kits) which is required for downstream NF-kappaB (show NFKB1 ELISA Kits) activation.
These studies demonstrate that, despite their similarity, TYRO3, AXL (show AXL ELISA Kits), and MER (show MERTK ELISA Kits) are likely to perform distinct functions in both immunoregulation and the recognition and removal of ACs (show PLA2G15 ELISA Kits).
This study mapped the autophosphorylation sites of murine Tyro3 to tyrosine 723 and 756, with K540 being required for its kinase activity.
Axl (show AXL ELISA Kits), Mertk (show MERTK ELISA Kits) and Tyro3 receptors are not required for Zika virus entry and infection.
genetic ablation of a receptor tyrosine kinase (show ERBB3 ELISA Kits) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
These results suggest that TAM (show CCNA1 ELISA Kits) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Optimal TAM (show CCNA1 ELISA Kits) signaling requires coincident TAM (show CCNA1 ELISA Kits) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 ELISA Kits) receptor tyrosine kinases Tyro3, Axl (show AXL ELISA Kits), and Mer (show ERH ELISA Kits) and their ligands Gas6 (show GAS6 ELISA Kits) and Protein S.
These findings indicate that Tyro3 is a critical signal for synovial hyperplasia, osteoclast differentiation and bone erosion during arthritis.
Axl (show AXL ELISA Kits) and Mer (show ERH ELISA Kits) (TAM (show CCNA1 ELISA Kits)) receptor tyrosine kinases (RTKs) developed persistent inflammatory liver damage resembling AIH. Tyro3(-/-)Axl (show AXL ELISA Kits)(-/-)Mer (show ERH ELISA Kits)(-/-) triple mutant (TAM (show CCNA1 ELISA Kits)(-/-)) mice exhibited chronic hepatitis
Adult brain neurogenesis is reduced in the hippocampus of the Tyro3-/-Axl (show AXL ELISA Kits)-/-Mertk (show MERTK ELISA Kits)-/- triple-knockout but not in single Tyro3-/- knockouts.
Chronic systemic inflammation and autoimmune disorders in the Tyro3, Axl (show AXL ELISA Kits) and Mertk (show MERTK ELISA Kits) knockout mice cause neuronal damage and death.
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
TYRO3 protein tyrosine kinase
, Tyrosine-protein kinase receptor TYRO3
, tyrosine-protein kinase receptor TYRO3
, developmental receptor tyrosine kinase
, tyrosine-protein kinase DTK
, tyrosine-protein kinase receptor TYRO3-like
, tyrosine-protein kinase RSE
, tyrosine-protein kinase SKY
, tyrosine-protein kinase TIF
, tyrosine-protein kinase byk
, Bruton agammaglobulinemia tyrosine kinase
, TYRO3 protein tyrosine kinase 3
, Axl-related receptor tyrosine kinase
, protein-tyrosine kinase
, retina-expressed kinase
, Xenopus kinase of Sky family
, tyrosine kinase