Browse our VEGFC Proteins (VEGFC)

Full name:
Vascular Endothelial Growth Factor C Proteins (VEGFC)
On are 84 Vascular Endothelial Growth Factor C (VEGFC) Proteins from 18 different suppliers available. Additionally we are shipping VEGFC Antibodies (301) and VEGFC Kits (66) and many more products for this protein. A total of 458 VEGFC products are currently listed.
AW228853, Flt4-L, VEGF-C, VEGFC, VRP, xvegf-c
list all proteins Gene Name GeneID UniProt
VEGFC 7424 P49767
VEGFC 22341 P97953
VEGFC 114111 O35757

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VEGFC Proteins (VEGFC) by Origin

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Top referenced VEGFC Proteins

  1. Human VEGFC Protein expressed in Escherichia coli (E. coli) - ABIN413872 : Werchau, Toberer, Enk, Dammann, Helmbold: Merkel cell carcinoma induces lymphatic microvessel formation. in Journal of the American Academy of Dermatology 2011 (PubMed)
    Show all 6 references for 413872

  2. Human VEGFC Protein expressed in CHO Cells - ABIN2666942 : Cai, Ma, Gu, Zu, Qu, Zheng: Survivin regulates the expression of VEGF-C in lymphatic metastasis of breast cancer. in Diagnostic pathology 2012 (PubMed)
    Show all 6 references for 2666942

  3. Mouse (Murine) VEGFC Protein expressed in Escherichia coli (E. coli) - ABIN1047898 : Fitz, Morris, Towler, Long, Burgess, Greco, Wang, Gassaway, Nickbarg, Kovacic, Ciarletta, Giannotti, Finnerty, Zollner, Beier, Leak, Turner, Wood: Characterization of murine Flt4 ligand/VEGF-C. in Oncogene 1997 (PubMed)
    Show all 3 references for 1047898

  4. Human VEGFC Protein expressed in Escherichia coli (E. coli) - ABIN1047897 : Lee, Gray, Yuan, Luoh, Avraham, Wood: Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 2 references for 1047897

  5. Rat (Rattus) VEGFC Protein expressed in Human Cells - ABIN2009156 : Mandriota, Pepper: [Lymphangiogenesis and biological activity ov vascular endothelial growth factor-C]. in Journal de la Société de biologie 1999 (PubMed)

  6. Human VEGFC Protein expressed in Wheat germ - ABIN1324984 : Singh, Tiem, Watkins, Cho, Wang, Olsen, Uehara, Mamalis, Luo, Oakey, Ambati: Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity. in Blood 2013 (PubMed)

More Proteins for VEGFC Interaction Partners

Zebrafish Vascular Endothelial Growth Factor C (VEGFC) interaction partners

  1. Vegfc acts through ERK (show MAPK1 Proteins) to induce sprouting and differentiation of trunk lymphatic progenitors.

  2. data not only reveal a non-canonical function of Mt2 (show MT2 Proteins) in angiogenesis, but also propose Mt2 (show MT2 Proteins) as a novel regulator of vegfc expression.

  3. Vegfc signaling increases mafba (show MAFB Proteins) expression to control downstream transcription

  4. Vegfc is dispensable for facial lymphatic sprouting but not for the complete development of the facial lymphatic network.

  5. In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1 (show CCBE1 Proteins), and Vegfc-driven sprouting is enhanced by local Ccbe1 (show CCBE1 Proteins) overexpression. Moreover, Vegfc- and Vegfr3 (show FLT4 Proteins)-dependent Erk (show MAPK1 Proteins) signaling is impaired in the absence of Ccbe1 (show CCBE1 Proteins).

  6. Vegfc has an essential role in lymphangiogenesis [review]

  7. The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 (show FLT4 Proteins) signaling in zebrafish.

  8. Vegfc acts in two distinct modes during development: as a paracrine factor secreted from arteries to guide closely associated lymphatic vasculature and as an autocrine factor to drive migratory persistence during angiogenesis.

  9. Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.

  10. Here, we show that vascular endothelial growth factor C (Vegfc), an angiogenic as well as a lymphangiogenic factor, is unexpectedly involved in this process in zebrafish.

Pig (Porcine) Vascular Endothelial Growth Factor C (VEGFC) interaction partners

  1. VEGF-C and VEGF-C156S genes have roles in the pro-lymphangiogenic growth factor therapy of lymphedema

  2. Transcription of the vascular endothelial growth factor C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in swine umbilical vein endothelial cells with classical swine fever virus acute infection.

  3. No difference in bioactivity was detected between porcine relaxin-1 (show RLN1 Proteins) and recombinant human relaxin-2 (show RLN1 Proteins) in either mice or rats.

  4. During progressive ischemia, functional and metabolic benefits of intramyocardial VEGF-C gene transfer were apparent. VEGF-C-induced collateral formation occurred at the site of gene transfer

Human Vascular Endothelial Growth Factor C (VEGFC) interaction partners

  1. Data show that VEGF-C, VEGF-D (show Figf Proteins), and VEGFR-3 (show FLT4 Proteins) were expressed in a substantial percentage of breast carcinomas.

  2. By treating LECs with VEGF (show VEGFA Proteins)-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early (show JUN Proteins)' transcription factors that showed a rapid transient upregulation VEGFR-3 (show FLT4 Proteins) stimulation. these results reveal an important and unanticipated role of HOXD10 (show HOXD10 Proteins) in the regulation of VEGFR-3 (show FLT4 Proteins) signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability.

  3. In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C. Integrin alpha4 and VEGF-C were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C expression had significantly shorter overall survival and tumor-free survival time.

  4. High VEGFC expression is associated with angiogenesis and lymphangiogenesis.

  5. Adiponectin (show ADIPOQ Proteins) promoted VEGF-C expression and secretion in human chondrosarcoma cells.

  6. HuR (show ELAVL1 Proteins) plays important roles in determining malignant aggressiveness and outcome in prostate cancer (PCa (show FLVCR1 Proteins)), especially in androgen-independent PCa (show FLVCR1 Proteins) cells, via the regulation of cell proliferation, migration, and expression of VEGF-A (show VEGFA Proteins), -C, and COX-2.

  7. Study showed that VEGF-C levels are high in hypervolemic and low in euvolemic (and hypovolemic) chronic kidney disease patients; serum VEGF-C levels were significantly correlated with bioimpedance spectroscopy measurements

  8. Taken together, we suggest that ELK3 (show ELK3 Proteins) is an upstream regulator of the NF-kappaB (show NFKB1 Proteins) signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression.

  9. These results indicate that VEGF-C-induced MSC (show MSC Proteins) osteogenesis is mediated through VEGFR2 (show KDR Proteins) and VEGFR3 (show FLT4 Proteins), and followed the activation of the ERK (show EPHB2 Proteins)/RUNX2 (show RUNX2 Proteins) signaling pathway.

  10. Overexpression of vascular endothelial growth factor C (VEGF-C) in Kazakh esophageal squamous cell carcinoma (ESCC) was significantly associated with gender, depth of tumor invasion, lymph node metastasis and tumor clinical stage.

Mouse (Murine) Vascular Endothelial Growth Factor C (VEGFC) interaction partners

  1. lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 (show Adamts2 Proteins) and CCBE1 (show CCBE1 Proteins) spatially and temporally patterns developing lymphatics, and one in which VEGFD (show Figf Proteins) activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth

  2. These results reveal an unexpected role for VEGF-C, a major lymphangiogenic growth factor, in the transition to fetal liver erythropoiesis.

  3. Results suggest that interleukin-6 (IL-6 (show IL6 Proteins)) increases VEGF-C induction and lymphangiogenesis may involve, at least in part, Src (show SRC Proteins)-FAK (show PTK2 Proteins)-STAT3 (show STAT3 Proteins) cascade in lymphatic endothelial cells (LECs).

  4. Data show that heparanase-1 (HPA-1 (show HPSE Proteins)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (show SDC1 Proteins)) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1 (show SDC1 Proteins)/VEGF-C complex into the medium of hepatocarcinoma cell.

  5. Data show that in the MCF-7 breast cancer cell line, only MT1X (show MT1X Proteins) metallothioneins (MTs (show NEU2 Proteins)) positively correlated with vascular endothelial growth factor C (VEGFC).

  6. The findings in this study strongly suggest the following: i) that VEGF-C promotes the proliferative activity and migratory ability of mesenchymal stem cell ; and ii) VEGF-C and Tgfb (show TGFB1 Proteins) reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes, respectively.

  7. The authors show that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine.

  8. MT1-MMP (show MMP14 Proteins) directly cleaves LYVE-1 (show LYVE1 Proteins) on lymphatic endothelial cells to inhibit LYVE-1 (show LYVE1 Proteins)-mediated lymphangiogenic responses and restrains the production of VEGF-C.

  9. HA increases lymphangiogenesis in renal fibrosis model and also stimulates vascular endothelial cell growth factor (show FGF1 Proteins)-C production from macrophages through Toll-like receptor 4 (show TLR4 Proteins)-dependent signal pathway

  10. Results showed that the VEGF-C/VEGFR-3 (show FLT4 Proteins) system underlies the protective effect of ischemic preconditioning against forebrain ischemia in the mouse hippocampus

VEGFC Protein Profile

Protein Summary

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.

Alternative names and synonyms associated with VEGFC

  • vascular endothelial growth factor c (vegfc)
  • vascular endothelial growth factor C (VEGFC)
  • vascular endothelial growth factor C (vegfc)
  • vascular endothelial growth factor C (Vegfc)
  • vascular endothelial growth factor C-like (LOC100525960)
  • AW228853 protein
  • Flt4-L protein
  • VEGF-C protein
  • VEGFC protein
  • VRP protein
  • xvegf-c protein

Protein level used designations for VEGFC

vascular endothelial growth factor C , vascular endothelial growth factor c , FLT4 ligand DHM , VEGF-C , vascular endothelial growth factor-related protein , VRP , flt4 ligand , flt4-L , vascular endothelial growth factor C isoform 129 , vascular endothelial growth factor C isoform 184

403049 Danio rerio
699502 Macaca mulatta
100380462 Salmo salar
734331 Xenopus laevis
100127470 Sus scrofa
7424 Homo sapiens
22341 Mus musculus
114111 Rattus norvegicus
100338211 Oryctolagus cuniculus
100724469 Cavia porcellus
282122 Bos taurus
482932 Canis lupus familiaris
422573 Gallus gallus
101105629 Ovis aries
100525960 Sus scrofa
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