Browse our COL4a3 Proteins (COL4a3)

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Collagen, Type IV, alpha 3 Proteins (COL4a3)
On are 9 Collagen, Type IV, alpha 3 (COL4a3) Proteins from 5 different suppliers available. Additionally we are shipping COL4a3 Antibodies (58) and COL4a3 Kits (6) and many more products for this protein. A total of 79 COL4a3 products are currently listed.
alpha3(IV), zTumstatin, [a]3(IV)
list all proteins Gene Name GeneID UniProt
COL4a3 12828 Q9QZS0
COL4a3 363265  
COL4a3 1285 Q01955

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Mouse (Murine) Collagen, Type IV, alpha 3 (COL4a3) interaction partners

  1. Report monoclonal antibody against the collagen type IV (show COL4 Proteins) alpha3NC1 domain as a marker for glomerular disease.

  2. Data show that deletion of tumstatin and TSP1 (show GZMA Proteins) in p53 (show TP53 Proteins)-/- mice leads to increased tumor burden and reduced survival.

  3. the pathogenetic role of USAG-1 (show SOSTDC1 Proteins) in Col4a3-/- mice might involve crosstalk between kidney tubules and the glomerulus and that inhibition of USAG-1 (show SOSTDC1 Proteins) may be a promising therapeutic approach for the treatment of Alport syndrome.

  4. Collagen alpha3(IV) nor alpha4(IV) were detected in the lens capsule 2 weeks postnatal.

  5. Matrix metalloproteinase-9 (show MMP9 Proteins) generated fragments of procollagen, type IV, alpha 3 has endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth.

  6. Alpha3(IV), alpha4(IV), and alpha5(IV) chains form a complex, which is a heterotrimer, and a defect in complex formation might be one of the molecular mechanisms underlying the pathogenesis of Alport syndrome.

  7. CCR1-mediated recruitment and local activation of macrophages contribute to disease progression in COL4A3-deficient mice. CCR1 is potential therapeutic target for Alport disease or other progressive nephropathies with interstitial macrophage infiltrates.

  8. Upregulation of Lama5 (show LAMA5 Proteins) transcription and concentration of laminin alpha1 and alpha5 within (Alport)collagen alpha3(IV) knockout glomerular basement membrane thickenings contribute to abnormal permeabilities.

  9. A single immunization of highly denatured recombinant mouse collagen IV (show COL4 Proteins) alpha 3 chain noncollagen domain induces severe glomerulonephritis in 100% of Wistar Kyoto rats.

Human Collagen, Type IV, alpha 3 (COL4a3) interaction partners

  1. COL4A3 gene expression is negatively regulated by ZEB1 binding to E2 box motifs in the COL4A3 promoter region.

  2. COL4A3 expression is significantly downregulated in human masticatory mucosa during wound healing

  3. New COL4A3 mutations among Portuguese patients with collagen IV (show COL4 Proteins)-related nephropathies were identified in 18 unrelated families.

  4. The results support the hypothesis that certain hypomorphic podocin variants may act as adverse genetic modifiers when co-inherited with COL4A3 mutations

  5. Letter/Case Report: novel COL4A3 gene mutations in a consanguineous family with autosomal recessive Alport syndrome.

  6. we identified seven families with associated mutations in COL4A3 and COL4A4 genes and four families with associated mutations in COL4A4 and COL4A5 (show COL4a5 Proteins). We did not find kindreds with digenic inheritance attributable to mutations in COL4A3 and COL4A5 (show COL4a5 Proteins)

  7. Functional studies in cultured podocytes transfected with wild type or mutant COL4A3 chains showed retention of mutant collagens and differential activation of the unfolded protein response cascade.

  8. We found that 7 out of 70 families (10%) with familial focal segmental glomerulosclerosis in our cohort have rare variants in COL4A3 and COL4A4.

  9. COL4A3 mutations cause focal segmental glomerulosclerosis.

  10. The expression of collagen type IV (show COL4 Proteins) and its alpha chains (alpha1-6) was investigated in different endothelial cell culture systems in vitro qualitatively and quantitatively.

COL4a3 Protein Profile

Protein Summary

Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Alternative names and synonyms associated with COL4a3

  • collagen, type IV, alpha 3 (Goodpasture antigen) (COL4A3)
  • collagen, type IV, alpha 3 (col4a3)
  • collagen, type IV, alpha 3 (Col4a3)
  • alpha3(IV) protein
  • zTumstatin protein
  • [a]3(IV) protein

Protein level used designations for COL4a3

type IV collagen alpha 3 chain , collagen alpha-3(IV) chain , collagen type IV alpha3 chain , procollagen, type IV, alpha 3 , tumstatin , collagen, type IV, alpha 3 (Goodpasture antigen) , collagen IV, alpha-3 polypeptide

424797 Gallus gallus
553354 Danio rerio
12828 Mus musculus
363265 Rattus norvegicus
1285 Homo sapiens
317711 Bos taurus
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