COL4a3 Protein (AA 1446-1667, partial) (His tag)

Catalog No. ABIN5709311

Product Details

Target: COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))

Protein Type: Recombinant

Protein Characteristics: AA 1446-1667, partial

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This COL4a3 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: GLKGKRGDSG SPATWTTRGF VFTRHSQTTA IPSCPEGTVP LYSGFSFLFV QGNQRAHGQD LGTLGSCLQR FTTMPFLFCN VNDVCNFASR NDYSYWLSTP ALMPMNMAPI TGRALEPYIS RCTVCEGPAI AIAVHSQTTD IPPCPHGWIS LWKGFSFIMF TSAGSEGTGQ ALASPGSCLE EFRASPFLEC HGRGTCNYYS NSYSFWLASL NPERMFRKPI PSTVKAGELE KIISRCQVCM KK

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))

Alternative Name: CO4A3 (COL4A3 Products)

Synonyms: zTumstatin Protein, [a]3(IV) Protein, alpha3(IV) Protein, collagen type IV alpha 3 chain Protein, collagen, type IV, alpha 3 Protein, COL4A3 Protein, col4a3 Protein, Col4a3 Protein

Background: Type IV collagen is the major structural component of glomerular basent mbranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity, these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.

Molecular Weight: 30.6 kDa

UniProt: Q01955

Pathways: Sensory Perception of Sound, Positive Regulation of Endopeptidase Activity