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Browse our anti-GJB2 (GJB2) Antibodies

Full name:
anti-Gap Junction Protein, beta 2, 26kDa Antibodies (GJB2)
On www.antibodies-online.com are 91 Gap Junction Protein, beta 2, 26kDa (GJB2) Antibodies from 20 different suppliers available. Additionally we are shipping GJB2 Kits (29) and GJB2 Proteins (4) and many more products for this protein. A total of 129 GJB2 products are currently listed.
Synonyms:
AI325222, Cnx26, connexin-26, CX26, CXN-26, DFNA3, DFNA3A, DFNB1, DFNB1A, Gjb-2, GJB2, HID, KID, MGC53062, NSRD1, PPK

Most Popular Reactivities for anti-GJB2 (GJB2) Antibodies

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anti-Mouse (Murine) GJB2 Antibodies:

anti-Rat (Rattus) GJB2 Antibodies:

anti-Human GJB2 Antibodies:

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Top referenced anti-GJB2 Antibodies

  1. Cow (Bovine) Polyclonal GJB2 Primary Antibody for WB - ABIN2774858 : Ulfig: Expression of connexin 26 in the ganglionic eminence of preterm infants after bleedings. in Neuroscience research 2004 (PubMed)

  2. Human Polyclonal GJB2 Primary Antibody for WB - ABIN374836 : Djalilian, McGaughey, Patel, Seo, Yang, Cheng, Tomic, Sinha, Ishida-Yamamoto, Segre: Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. in The Journal of clinical investigation 2006 (PubMed)

More Antibodies against GJB2 Interaction Partners

Xenopus laevis Gap Junction Protein, beta 2, 26kDa (GJB2) interaction partners

  1. Using reconstituted hemichannels in a liposome-based transport-specific fractionation assay, we confirmed that homomeric Cx26 and Cx32 (show GJB1 Antibodies) and heteromeric Cx26/Cx32 (show GJB1 Antibodies) are permeable to GSH and other endogenous reductants.

Mouse (Murine) Gap Junction Protein, beta 2, 26kDa (GJB2) interaction partners

  1. Reduced Cx26 expression in the mature mouse cochlea may increase susceptibility to noise-induced hearing loss .

  2. mir (show MLXIP Antibodies)-27a was identified as an apoptotic molecule that participates in Cx26 knockout-induced apoptosis in the cochlear sensory epithelium of mice by downregulating sgk1 (show SGK1 Antibodies) expression

  3. Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer.

  4. Cx26-mediated intercellular communication is required for cochlear development and that deficiency of Cx26 can impair miRNA-mediated intercellular genetic communication in the cochlea, which may lead to cochlear developmental disorders

  5. presence of Cx30 (show GJB6 Antibodies) in the cochlea does not compensate for Cx26 loss, and the absence of both connexins from vestibular sensory epithelia is no more injurious than the absence of one of them

  6. Reciprocal positive regulation between Cx26 and PI3K/Akt (show AKT1 Antibodies) pathway confers acquired gefitinib resistance in non-small-cell lung carcinoma cells by promoting epithelial mesenchymal transition via a gap-junctional communication-independent manner.

  7. The inserting reconstituted gap junction Cx26 liposomes into the oocytes allowed the demonstration of intracellular/extracellular Ca(2 (show CA2 Antibodies)+)-regulated hemi-channel activities.

  8. Study used an inducible gene knockout technique to delete Cx26 expression in the cochlea after birth, results suggest that Cx26 deficiency may impair active cochlear amplification leading to late-onset hearing loss

  9. These results suggest that low levels of Cx26 expression throughout pregnancy and lactation, and not the physiological surge in Cx26, is sufficient for normal gland development and function.

  10. These results suggest that successful treatment of Cx26 deafness requires early intervention before the cochlea fully matures.

Human Gap Junction Protein, beta 2, 26kDa (GJB2) interaction partners

  1. We attempted to identify the genetic epidemiology of hereditary hearing loss among the Chinese Han population using next-generation sequencing The entire length of the genes GJB2, SLC26A4, and GJB3 were sequenced from 116 individuals suffering from hearing loss. In our study, SLC26A4 and GJB2 were the most frequently affected genes among the Chinese Han population with hearing loss.

  2. Somatic mutation in GJB2 gene cause nevoid spiny hyperkeratosis.

  3. There was a high prevalence of IVS1+1G>A mutation in this sample of deaf families in Syria.

  4. homozygous GJB2 c.109G[A mutation may be a cause of sudden death involving both ears.

  5. study suggests that the GJB2 235delC polymorphism, but not the 30-35delG variant, contributes to congenital deafness susceptibility in the Chinese population examined

  6. We report here a non consanguineous assortatively mating hearing impaired family with one of the hearing impaired partners, their hearing impaired sibling and hearing impaired offspring showing compound heterozygosity in the GJB2 gene, involving a dominant mutation p.R184Q and two recessive mutations p.Q124X and c.IVS 1+1G>A in a unique triallelic combination.

  7. There are more than 39 deafness genes reported to cause non-syndromic hereditary hearing loss (HHL) in Iran, of which the most prevalent causative genes include GJB2, SLC26A4, MYO15A, and MYO7A. In addition, we highlight some of the more common genetic causes of syndromic HHL in Iran. [review]

  8. Two GJB2 mutations, c.del35G with an allele frequency of 4.7 % and R32C (3.7 %) were detected in Mauritanian children with non-syndromic hearing loss.

  9. Our results showed that the GJB2 gene is a major contributor to non syndromic hearing loss in Morocco

  10. Compound heterozygous variants c.94C > T (p.R32C) and c.235delC (p.L79Cfs*3) in the GJB2 gene were identified in the two patients of an autosomal recessive non-syndromic hearing loss family, and the heterozygous GJB2 c.94C > T and c.235delC variants were identified in his unaffected father and mother, respectively.

Cow (Bovine) Gap Junction Protein, beta 2, 26kDa (GJB2) interaction partners

  1. intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26, Cx32 (show GJB1 Antibodies), and Cx43 (show GJA1 Antibodies)

GJB2 Antigen Profile

Antigen Summary

This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness.

Alternative names and synonyms associated with GJB2

  • gap junction protein, beta 2, 26kDa (gjb2) antibody
  • gap junction protein, beta 2, 26kDa (GJB2) antibody
  • gap junction protein, beta 2 (Gjb2) antibody
  • AI325222 antibody
  • Cnx26 antibody
  • connexin-26 antibody
  • CX26 antibody
  • CXN-26 antibody
  • DFNA3 antibody
  • DFNA3A antibody
  • DFNB1 antibody
  • DFNB1A antibody
  • Gjb-2 antibody
  • GJB2 antibody
  • HID antibody
  • KID antibody
  • MGC53062 antibody
  • NSRD1 antibody
  • PPK antibody

Protein level used designations for GJB2

gap junction protein, beta 2, 26kDa , connexin 26 , connexin 29 , gap junction membrane channel protein beta 6 , gap junction protein, beta 2, 26kDa (connexin 26) , connexin-26 , gap junction beta-2 protein , gap junction membrane channel protein beta 2 , gap junction channel protein connexin 26 , connexin26 , gap junction protein beta 2 , connexin 26 protein , cx26

GENE ID SPECIES
380170 Xenopus laevis
467220 Pan troglodytes
14619 Mus musculus
394266 Rattus norvegicus
100379528 Cavia porcellus
2706 Homo sapiens
403570 Canis lupus familiaris
407154 Bos taurus
443345 Ovis aries
704224 Macaca mulatta
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