GJB2 Products
(Gap Junction Protein, beta 2, 26kDa (GJB2))
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This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008].
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Featured GJB2 Categories
GJB2 Antibodies
High quality antibodies with extensive validation data.
GJB2 ELISA Kits
Reliable ELISA kits for a wide range of species.
GJB2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GJB2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7153609
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS
Validations
- (3)
Cat. No.
ABIN190896
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (4)
- (2)
Cat. No.
ABIN544540
Quantity
400 μL
Datasheet
Datasheet
Recommended GJB2 ELISA Kits
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Analytical Method
Quantitative Sandwich ELISA
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Cat. No.
ABIN6966962
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966961
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Cat. No.
ABIN6956053
Quantity
96 tests
Datasheet
Datasheet
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Source
Wheat germ
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Cat. No.
ABIN1355142
Quantity
25 μg
Datasheet
Datasheet
Reactivity
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Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3097181
Quantity
1 mg
Datasheet
Datasheet
Reactivity
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Source
Tobacco (Nicotiana tabacum)
Validations
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Cat. No.
ABIN3121332
Quantity
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Datasheet
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Latest Publications for our GJB2 products
: "Connexin 26 Expression in Mammalian Cardiomyocytes." in: Scientific reports, Vol. 8, Issue 1, pp. 13975, (2018) (PubMed).: "Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules." in: The Journal of general physiology, Vol. 146, Issue 3, pp. 245-54, (2015) (PubMed).
: "Insights on the mechanisms of Ca(2+) regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y)." in: The Journal of general physiology, Vol. 142, Issue 1, pp. 23-35, (2013) (PubMed).
: "Inhibition of connexin 26 by the AMP-activated protein kinase." in: The Journal of membrane biology, Vol. 240, Issue 3, pp. 151-8, (2011) (PubMed).
: "Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response." in: The Journal of clinical investigation, Vol. 116, Issue 5, pp. 1243-53, (2006) (PubMed).
: "GJB2 deafness gene shows a specific spectrum of mutations in Japan, including a frequent founder mutation." in: Human genetics, Vol. 112, Issue 4, pp. 329-33, (2003) (PubMed).
: "Novel mutations in GJB2 encoding connexin-26 in Japanese patients with keratitis-ichthyosis-deafness syndrome." in: The British journal of dermatology, Vol. 148, Issue 4, pp. 649-53, (2003) (PubMed).
: "The novel R75Q mutation in the GJB2 gene causes autosomal dominant hearing loss and palmoplantar keratoderma in a Turkish family." in: Clinical genetics, Vol. 62, Issue 4, pp. 306-9, (2002) (PubMed).
: "Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A-->G mitochondrial mutation." in: American journal of medical genetics, Vol. 103, Issue 4, pp. 334-8, (2001) (PubMed).
Synonyms and alternative names related to GJB2
gap junction protein beta 2 L homeolog (gjb2.L), gap junction protein beta 2 (GJB2), gap junction protein, beta 2 (Gjb2), gap junction protein beta 2 (Gjb2), AI325222, Cnx26, connexin-26, cx26, Cx26, CX26, CXN-26, dfna3, DFNA3, dfna3a, DFNA3A, dfnb1, DFNB1, dfnb1a, DFNB1A, Gjb-2, GJB2, HID, KID, MGC53062, nsrd1, NSRD1, ppk, PPKProtein level used designations for GJB2
- gap junction protein, beta 2, 26kDa
- connexin 26
- connexin 29
- gap junction membrane channel protein beta 6
- gap junction protein, beta 2, 26kDa (connexin 26)
- connexin-26
- gap junction beta-2 protein
- gap junction membrane channel protein beta 2
- gap junction channel protein connexin 26
- connexin26
- gap junction protein beta 2
- connexin 26 protein
- cx26
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