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Cnn and PLP directly interact at two defined sites to coordinate the cell cycle-dependent rearrangement and scaffolding activity of the centrosome to permit normal centrosome organization, cell division, and embryonic viability.
Basal body formation in the male testes and the production of functional sperm does not rely on the PLP-CaM (show CALM ELISA Kits) interaction, whereas production of functional mechanosensory neurons does.
Data indicate that interphase centrioles are closely associated with Sas-4, Spd-2, Polo kinase (show PLK1 ELISA Kits), Pericentrin-like protein (Dplp), Asterless (Asl (show ADSL ELISA Kits)), Plk4 (show PLK4 ELISA Kits) kinase, Centrosomin (show EIF3A ELISA Kits) (Cnn) and gamma-tubulin (show TUBG1 ELISA Kits).
identification of CP309 which can bind to calmodulin (show CALM ELISA Kits); it is is required for microtubule nucleation mediated by centrosomes and it interacts with the gamma-tubulin (show TUBG1 ELISA Kits) small complex
we identified two novel mutations in the PCNT gene associated with Microcephalic osteodysplastic primordial dwarfism type II and intracranial aneurysms
PCNT has to be phosphorylated by PLK1 (show PLK1 ELISA Kits) to be a suitable substrate of separase (show ESPL1 ELISA Kits).
Cep68 degradation allows Cep215 (show CDK5RAP2 ELISA Kits) removal from peripheral pericentriolar material (PCM (show PCMT1 ELISA Kits)) preventing centriole separation following disengagement, PCNT cleavage mediates Cep215 (show CDK5RAP2 ELISA Kits) removal from core of the PCM (show PCMT1 ELISA Kits) to inhibit centriole disengagement and duplication
The CEP215 (show CDK5RAP2 ELISA Kits)-pericentrin interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis.
Data suggest that changes in the expression levels of PCNT in DS subjects may be involved into the molecular mechanism of Down's syndrome.
PCNT gene mutation is associated with hematological abnormalities in patients with microcephalic osteodysplastic primordial dwarfism type II.
Che-1 (show BCHE ELISA Kits) depletion abolishes the ability of Chk1 (show CHEK1 ELISA Kits) to bind pericentrin and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 (show CDK1 ELISA Kits) and advances entry into mitosis.
The pericentrin B cleavage is essential for timely centriole disengagement and duplication.
Kendrin is a novel and crucial substrate for separase (show ESPL1 ELISA Kits) at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis.
Expression of RRP1B, PCNT, KIF21A (show KIF21A ELISA Kits) and ADRB2 (show ADRB2 ELISA Kits) in leucocytes of Down's syndrome subjects, was analyzed.
Meiotic division is highly error-prone in the absence of Pcnt and disrupted acentriolar microtubule-organizing centers.
Pericentrin is a key functional component of the unique acentriolar MTOCs of mouse oocytes, and plays an important role in regulating meiotic spindle assembly and/or stability.
The mouse Pcnt(-/-) phenotype was associated with misdirected ventricular septal growth in the heart, decreased proliferative symmetric divisions in brain neural progenitors, and increased misoriented divisions in fibroblasts.
Findings suggest distinct functional roles of several Pcnt variants in different ciliated tissues and sensory neurons, like the olfactory epithelium and the retina of the mouse
A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice
results confirm that MT1-MMP (show MMP14 ELISA Kits) cleaves pericentrin-2 in humans but not in mice and that mouse models of cancer probably cannot be used to critically examine MT1-MMP (show MMP14 ELISA Kits) functionality
Pcnt was shown to be localized to the base of primary cilia in multiple embryonic tissues, in agreement with a recent study demonstrating the involvement of Pcnt in primary cilia formation using cultured mammalian cells.
Pericentrin forms complexes with CHD3 (show CHD3 ELISA Kits) and CHD4 (show CHD4 ELISA Kits), but a distinct CHD3 (show CHD3 ELISA Kits)-pericentrin complex is required for centrosomal anchoring of pericentrin/gamma-tubulin (show TUBG1 ELISA Kits) and for centrosome integrity.
pPKCdelta(Thr505) interacts with MTOC-associated proteins pericentrin and gamma-tubulin (show TUBG1 ELISA Kits), and plays a role in meiotic spindle organization in oocytes
pericentrin is essential for the assembly of chemosensory cilia of olfactory receptor neurons, but it is not globally required for cilia formation in mammals.
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II.
, drosophila pericentrin like protein
, lethal (3) s2172
, pericentrin-like protein
, pericentrin/AKAP450 centrosomal targeting
, pericentrin B
, DIP2 disco-interacting protein 2 homolog A
, pericentrin (kendrin)
, pericentrin 2 (kendrin)
, pericentrin 2