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Chicken Polyclonal SOD2 Primary Antibody for ELISA, ICC - ABIN151490
Dumont, Wille, Stack, Calingasan, Beal, Lin: Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Show all 15 Pubmed References
Rat (Rattus) Polyclonal SOD2 Primary Antibody for WB - ABIN152304
Siu, Alway: Id2 and p53 participate in apoptosis during unloading-induced muscle atrophy. in American journal of physiology. Cell physiology 2005
Show all 6 Pubmed References
Dog (Canine) Monoclonal SOD2 Primary Antibody for IF, WB - ABIN968602
Ambrosone, Freudenheim, Thompson, Bowman, Vena, Marshall, Graham, Laughlin, Nemoto, Shields: Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. in Cancer research 1999
Show all 5 Pubmed References
Dog (Canine) Monoclonal SOD2 Primary Antibody for IF, WB - ABIN968603
Gilks, Price, Wright, Churg: Antioxidant gene expression in rat lung after exposure to cigarette smoke. in The American journal of pathology 1998
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Human Polyclonal SOD2 Primary Antibody for IHC (fro), IHC (p) - ABIN151468
Dumont, Stack, Elipenahli, Jainuddin, Gerges, Starkova, Yang, Starkov, Beal: Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011
Show all 5 Pubmed References
Human Polyclonal SOD2 Primary Antibody for IF (p), IHC (p) - ABIN737361
Khan, Chen, Wan, Tania, Xu, Chen, Zhang: Regulatory effects of resveratrol on antioxidant enzymes: a mechanism of growth inhibition and apoptosis induction in cancer cells. in Molecules and cells 2013
Show all 4 Pubmed References
Chicken Polyclonal SOD2 Primary Antibody for IP, IHC - ABIN361648
Adachi, Ohta, Yamada, Futenma, Kato, Hirano: Quantitative analysis of extracellular-superoxide dismutase in serum and urine by ELISA with monoclonal antibody. in Clinica chimica acta; international journal of clinical chemistry 1993
Show all 10 Pubmed References
Chicken Polyclonal SOD2 Primary Antibody for ICC, IF - ABIN361656
Gao, Flores, Leff, Bose, McCord: Synthesis and anti-inflammatory activity of a chimeric recombinant superoxide dismutase: SOD2/3. in American journal of physiology. Lung cellular and molecular physiology 2003
Show all 10 Pubmed References
Rat (Rattus) Polyclonal SOD2 Primary Antibody for WB - ABIN152303
Shi, So, Man, Vanhoutte: Oxygen-derived free radicals mediate endothelium-dependent contractions in femoral arteries of rats with streptozotocin-induced diabetes. in British journal of pharmacology 2007
Show all 3 Pubmed References
Human Polyclonal SOD2 Primary Antibody for IHC, IHC (p) - ABIN4355070
Lindfors, Nilsson, Garcia-Roves, Zuberi, Karimi, Donahue, Roopenian, Mulder, Uhlén, Ekström, Davisson, Hökfelt, Schalling, Johansen: Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse. in Proceedings of the National Academy of Sciences of the United States of America 2011
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Prion (show PRNP Antibodies) propagation exacerbates an apoptotic pathway whereby mitochondrial dysfunction follows mislocalisation of SOD2 to cytosolic caspases permitting its degradation.
Depletion of superoxide dismutases promotes muscular and neuronal ROS (show ROS1 Antibodies) accumulation which may have a significant effect on age-dependent impairment of the Drosophila adults.
Paraquat exposure, but not Sod2 knockdown, resulted in increased carbonylated protein relative abundance.
The functional SOD1 (show SOD1 Antibodies) and SOD2 genes knockout and their overexpression in neurons and glial tissue increase the sensitivity of Drosophila melanogaster to oxidative stress conditions.
ocytes lacking maternal SOD2 protein develop into adults just like normal SOD2-containing oocytes suggesting that maternal SOD2-mediated protection against mitochondrial ROS (show ROS1 Antibodies) is not essential for oocyte viability
Muscles appear to be more sensitive to superoxide attack relative to the neurons and such overt phenotypes observed in SOD2-deficient animals can be directly attributed to the muscle.
Overexpression of Cu,ZnSOD (show SOD1 Antibodies) and MnSOD in transgenic Drosophila.
Ablation of mitochondrial SOD2 through expression of a GAL4 (show LGALS4 Antibodies)-regulated, inverted-repeat Sod2 RNA-interference causes increased endogenous oxidative stress, loss of respiratory chain & TCA cycle components,& early-onset mortality in young adults.
Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity.
The chromosomal deficiency Df(2R)017 significantly up-regulated MnSOD mRNA by 1.7-fold. Deficiency in four other genomic intervals, Df(1)ct-J4, Df(2L)BSC4, Df(3L)66C-G28 and Df(3R)Scr (show SCRIB Antibodies), down-regulated MnSOD expression.
SOD1 (show SOD1 Antibodies) and SOD2 provide independent protection to compartment-specific protein iron-sulfur clusters against attack by superoxide generated under oxidative stress
SOD2 and GPX1 (show GPX1 Antibodies) can interact to affect cancer risk and progression indicated that it is the net accumulation of mitochondrial H2O2 (mtH2O2) resulting from of the balance between the activities SOD2 and anti-oxidants such as GPX1 (show GPX1 Antibodies) that determines whether SOD2 prevents or promotes oncogenesis. Review.
Low MnSOD expression is associated with Prostate Cancer.
High MNSOD expression is associated with Thyroid Tumors.
Findings suggest that the Ala16Val-MnSOD SNPs may contribute to hypercholesterolemia and higher GLU (show DCTN1 Antibodies) levels, increasing the risk to neurovascular events that may lead to stroke.
Results suggest some pharmacogenetic effects of Val16Ala-SOD2 in hypercholesterolemia patients undergoing rosuvastatin treatment.
he data demonstrated that linalool exhibited inhibitory effect on glioma cells through regulation of SIRT3 (show SIRT3 Antibodies)-SOD2-ROS (show ROS1 Antibodies) signaling
WT-MnSOD protein conserves a destabilizing amino acid at position 146 as part of a strategy to favor metal ion binding.
There is significant association between SOD (show SOD1 Antibodies) rs4880 polymorphism and pulmonary arterial hypertension (PAH) susceptibility, and this polymorphism influenced PAH susceptibility by altering the expression of SOD2.
It is suggested that the MnSOD A16V polymorphism may be associated with a risk of female infertility in northern Iran.
Mutated obese carries of SOD1 (show SOD1 Antibodies) -251, SOD2 47 and CAT -262 are associated with a higher distribution of fat in comparison with obese wild-type carriers.
show that ischemia markedly potentiated the expression of arginase-1 (show ARG1 Antibodies), and also induced the SOD2 in the wound tissue.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2, GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1 (show NR3C1 Antibodies). TNF (show TNF Antibodies) and IL6 (show IL6 Antibodies) levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
Data suggest that during ectogenesis of blastocysts infected with bovine Herpesvirus type 5, expression of SOD2 (Mn) remains high indicating intense mitochondrial activity; this effect may be involved in inhibition of apoptosis in infected embryos.
expression profile of SOD2 in follicles: oocytes (SOD2 restricted to ooplasm (show NLRP5 Antibodies)); cumulus cells (expressed some SOD2); follicular fluid (small follicles show increased amounts of SOD2 in comparison with large follicles)
Shear stress influences spatial variations in vascular Mn-SOD expression with implications for LDL nitration.
The expression of SOD1 (show SOD1 Antibodies) and SOD2 through the course of the estrous cycle is reported.
Heart mitochondrial nucleoids contained SOD2, aortic endothelial cell mitochondrial nucleoids did not
results suggest that Sod2 is a target gene of LRH-1 (show NR5A2 Antibodies), and that LRH-1 (show NR5A2 Antibodies) agonists can mediate a reduction in ROS (show ROS1 Antibodies) production and oxidative stress driven by an excess of fatty acids, as exhibited in nonalcoholic fatty liver disease
We investigated the role of Mn-SOD in NIHL by examining the extent of hearing loss and hair cell damage after noise exposure in C57BL/6 wild-type (WT) mice and Mn-SOD heterozygous knockout (HET) mice. Mean ABR thresholds were significantly worse on post-noise exposure days 7 and 14 in HET mice compared with WT mice. Outer hair cell damage was significantly greater in all cochlear turns in HET mice compared with WT mice.
Data suggest that negative regulatory effect of Sirt3 (show SIRT3 Antibodies) on Nlrp3 (show NLRP3 Antibodies) inflammasome assembly in macrophages due to prolonged fasting occurs via Sirt3 (show SIRT3 Antibodies)-mediated deacetylation of mitochondrial Sod2, leading to Sod2 activation; prolonged fasting blunts inflammasomes in wild-type mice but not in Sirt3 (show SIRT3 Antibodies) knock-out mice. (Sirt3 (show SIRT3 Antibodies) = sirtuin 3 (show SIRT3 Antibodies); Nlrp3 (show NLRP3 Antibodies) = NLR (show CXCR5 Antibodies) family, pyrin domain containing 3 protein; Sod2 = superoxide dismutase 2)
Data show that overexpression of manganese superoxide dismutase (MnSOD) increased the expression of aquaporin-1 (AQP1 (show AQP1 Antibodies))
Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 (show SIRT3 Antibodies) enrichment within the mitochondria and subsequent upregulation of FoxO3a (show FOXO3 Antibodies)-mediated mitochondria gene expression of PGC-1alpha (show PPARGC1A Antibodies) and SOD2.
Thus, a ROS (show ROS1 Antibodies)-dependent epigenetic positive regulation of Sod2 gene expression likely represents a defense mechanism prolonging eNOS (show NOS3 Antibodies) function in aging mouse femoral arteries.
In this review, we will conglomerate the current aspects by which MnSOD can contribute to embryonic stem cells' and adult stem cells' functions and interpret the necessity of understanding MnSOD for further stem cell mediated applications
The results indicated that the inconsistency between Mn SOD expression and its activity might contribute to the development of recognition dysfunction induced by chronic Al overload.
Evidence for a tumor suppressive role of MnSOD in liver, where the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and hypoxia pathway may be crucial elements.
SOD2 overexpression in cardiomyocytes enhances mitochondrial function and metabolic vasodilation, leading to a phenotype of supernormal cardiac function.
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, manganese superoxide dismutase
, Mn Sod
, Mn superoxide dismutase
, superoxide dismutase 2, mitochondrial
, superoxide dismutase [Mn], mitochondrial
, Mn-superoxide dismutase
, mitochodnrial SOD
, mitochondrial Mn-superoxide dismutase 2
, mitochondrial MnSOD
, mitochondrial superoxide dismutase 2
, superoxide dismutase
, superoxide dismutase 2
, superoxide dismutase 2 (Mn)
, superoxide dismutase-2
, indophenoloxidase B
, manganese-containing superoxide dismutase
, mangano-superoxide dismutase
, superoxide dismutase (Mn type)
, manganous superoxide dismutase
, manganese SOD
, Superoxide dimutase 2, mitochondrial