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In conclusion, TMPRSS3 (show TMPRSS4 Proteins) and TNFRSF11B (show TNFRSF11B Proteins) may have potential prognostic value to be used as tumor biomarkers in breast cancer patients.
different combinations of TMPRSS3 (show TMPRSS4 Proteins) mutations led to different hearing impairment phenotypes (DFNB8/DFNB10) in the Chinese family.
TMPRSS3 (show TMPRSS4 Proteins) mutations seem to be an important cause of autosomal recessive nonsyndromic hearing loss in Slovenia resulting in rather uniform phenotype with profound congenital hearing loss.
Study demonstrated that TMPRSS3 contributes to ovarian cancer cell proliferation, invasion and metastasis, probably via activation of the ERK1/2 signaling pathway.
TMPRSS3 (show TMPRSS4 Proteins) expression is an independent prognostic factor for breast cancer patients. Bioinformatic analysis of potential TMPRSS3 (show TMPRSS4 Proteins) binding proteins revealed that TMPRSS3 (show TMPRSS4 Proteins) could be a key regulator of cancer pathways.
Low expression levels of hepsin (show HPN Proteins) and TMPRSS3 (show TMPRSS4 Proteins) are associated with poor breast cancer survival
Single nucleotide polymorphisms in TMPRSS3 (show TMPRSS4 Proteins) (rs3814903 and rs11203200) are significantly associated with breast cancer risk.
homozygous mutation TMPRSS3 (show TMPRSS4 Proteins): c.535G>A causes prelingual hearing loss in this Tibetan family
The prevalence of TMPRSS3 (show TMPRSS4 Proteins) mutations among Korean postlingual hearing loss is 8.3 %. The p.A306T variant of TMPRSS3 (show TMPRSS4 Proteins) is the common founder allele in Koreans. A novel variant, p.T248M of TMPRSS3 (show TMPRSS4 Proteins), was predicted to have milder pathogenicity.
Description of the spectrum of mutations in TMPRSS3 (show TMPRSS4 Proteins) in 374 families with autosomal recessive, non-syndromic hearing loss from India.
miR (show MLXIP Proteins)-204 has a role in suppressing cochlear spiral ganglion neuron survival in vitro by targeting TMPRSS3
Lack of Tmprss3 leads to a decrease in Kcnma1 (show KCNMA1 Proteins) potassium channels expression in cochlear inner hair cells.
The distribution of TMPRSS3 was observed in many regions of the mouse cochlea, but mainly in the spiral ganglion neurons.
Tmprss3 acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.
transmembrane protease, serine 3
, transmembrane protease serine 3-like
, serine protease TADG-12
, transmembrane protease serine 3
, tumor-associated differentially-expressed gene 12 protein
, transmembrane proteinase serine 3