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Browse our COL4A1 Proteins (COL4A1)

Full name:
Collagen, Type IV, alpha 1 Proteins (COL4A1)
On www.antibodies-online.com are 16 Collagen, Type IV, alpha 1 (COL4A1) Proteins from 5 different suppliers available. Additionally we are shipping COL4A1 Antibodies (97) and COL4A1 Kits (35) and many more products for this protein. A total of 153 COL4A1 products are currently listed.
Synonyms:
arresten, Bru, Col4a-1, col4a1, Del(8)44H, HANAC, ICH, POREN1, Raw, Svc, wu:fc02g11
list all proteins Gene Name GeneID UniProt
COL4A1 1282 P02462
COL4A1 12826 P02463
Rat COL4A1 COL4A1 290905  

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COL4A1 Proteins (COL4A1) by Origin

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More Proteins for COL4A1 Interaction Partners

Zebrafish Collagen, Type IV, alpha 1 (COL4A1) interaction partners

  1. the shiomaneki (sio) gene locus encodes Col4a6 (show COL4a6 Proteins), a subunit of type IV collagen (show COL4 Proteins), which, in a complex with Col4a5, is a basement membrane (BM) component. Both col4a5 and col4a6 (show COL4a6 Proteins) mutants displayed similar abnormalities in the axogenesis

  2. During motor axon regeneration, col4a5 destabilizes axons probing inappropriate trajectories to ensure target-selective regeneration, possible through slit1a.

  3. Genetic and biochemical studies indicate that Slit binds to Dragnet (Col4a5) which forms the basement membrane on the surface of the tectum.

Human Collagen, Type IV, alpha 1 (COL4A1) interaction partners

  1. Mutations upregulating COL4A1 expression lead topontine autosomal dominant microangiopathy with leukoencephalopathy (PADMAL).

  2. The study shows an association of the COL4A1 gene with cerebral palsy and suggests a potential role of COL4A1 in the pathogenesis of this disease.

  3. Differential protein expression of collagen IV (show COL4 Proteins), laminin alpha2, and nidogen-1 (show NID1 Proteins) indicated basal lamina remodeling develops in ischemic failing versus nonfailing human hearts.

  4. COL4A1 expression is significantly upregulated in human masticatory mucosa during wound healing.

  5. The findings indicate the critical role of CatB in regulating the expression of collagens III and IV by fibroblasts via prolonging TLR2/NF-kappaB (show NFKB1 Proteins) activation and oxidative stress.

  6. pulmonary complications should be considered in patients with COL4A1 mutation-related disorders.

  7. Chromosomal analysis and array-CGH showed no aberration. Target capture sequencing for COL4A1 and COL4A2 (show COL4a2 Proteins) revealed a de novo COL4A1 mutation (c.2123G>T [p.Gly708Val]).

  8. In porencephaly subjects with COL4A1 mutation, we did not detect significant alterations of immunofluorescence patterns in basal membranes of different skin structures. Heterozygous COL4A1 G749S mutation is associated with a normal immunofluorescence pattern of skin basement membranes.

  9. High serum Collagen Type IV (show COL4 Proteins) is associated with ovarian and breast cancer.

  10. Hydroxylation and O-linked glycosylation sites in col4a1 from human lens capsule.

Mouse (Murine) Collagen, Type IV, alpha 1 (COL4A1) interaction partners

  1. This extensive description of the muscular phenotype of the Col4a1 HANAC murine model suggests a potential contribution of primary endothelial cell defects, together with muscle BM alterations, to the development of COL4A1-related myopathy.

  2. The findings indicate the critical role of CatB in regulating the expression of collagens III and IV by fibroblasts via prolonging TLR2/NF-kappaB (show NFKB1 Proteins) activation and oxidative stress.

  3. data show that both basement membrane defects and ER stress contribute to Col4a1 renal disease, which has important implications for the development of treatment strategies for collagenopathies

  4. Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A (show PDGFA Proteins)), a potent chemotactic factor for fibroblasts.

  5. Col4a1 mutations cause abnormal vascular development, which triggers small-vessel disease, recurrent hemorrhagic strokes, and age-related macroangiopathy.

  6. Down-regulation let-7 by transforming growth factor-beta1-induced Lin28 (show LIN28A Proteins) upregulates collagen expression in glomerular mesangial cells from diabetic mice.

  7. COL4A1 and COL4A2 (show COL4a2 Proteins) mutations are pleiotropic and cause a wide spectrum of disorders, including ocular dysgenesis, brain malformations and myopathy, of variable severity in both mice and humans.

  8. WT1 (show WT1 Proteins) maintains testicular cord integrity by additively regulating the expression of basal lamina components Col4a1 and Col4a2 (show COL4a2 Proteins) with SOX9 (show SOX9 Proteins).

  9. show that heterozygous Col4a1 mutant mice have ocular dysgenesis, neuronal localization defects, and myopathy characteristic of Muscle-eye-brain disease/Walker-Warburg syndrome

  10. Data suggest that podocyte von Hippel-Lindau protein (show VHLL Proteins) is required for normal maintenance of podocytes, basment membrane collagen {alpha}1{alpha}2{alpha}1(IV) deposition and ultrastructure, neuroglobin (show NGB Proteins) experssion and glomerular barrier properties.

Cow (Bovine) Collagen, Type IV, alpha 1 (COL4A1) interaction partners

  1. High shear stress up-regulates type IV collagen (show COL4 Proteins) synthesis and down-regulates MMP-2 (show MMP2 Proteins) secretion in endothelial cells.

  2. alpha1.alpha2 stabilize the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys (show LYZ Proteins) cross-links

COL4A1 Protein Profile

Protein Summary

This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Alternative names and synonyms associated with COL4A1

  • collagen, type IV, alpha 5 (Alport syndrome) (col4a5)
  • collagen, type IV, alpha 1 (COL4A1)
  • collagen, type IV, alpha 1 (LOC100224679)
  • collagen, type IV, alpha 1 (Col4a1)
  • arresten protein
  • Bru protein
  • Col4a-1 protein
  • col4a1 protein
  • Del(8)44H protein
  • HANAC protein
  • ICH protein
  • POREN1 protein
  • Raw protein
  • Svc protein
  • wu:fc02g11 protein

Protein level used designations for COL4A1

collagen alpha-5(IV) chain , drg , dragnet , type IV collagen alpha 1 , collagen, type IV, alpha 1 , collagen type IV alpha 1 chain , collagen alpha-1(IV) chain-like , COL4A1 NC1 domain , collagen IV, alpha-1 polypeptide , collagen alpha-1(IV) chain , collagen of basement membrane, alpha-1 chain , Del(8)Bru44H , alpha1(IV) collagen , procollagen, type IV, alpha 1 , retinal anterior wiring , alpha 1 type IV collagen , collagen IV a1 chain

GENE ID SPECIES
323561 Danio rerio
403496 Canis lupus familiaris
700281 Macaca mulatta
100478752 Ailuropoda melanoleuca
100224679 Taeniopygia guttata
1282 Homo sapiens
12826 Mus musculus
282191 Bos taurus
290905 Rattus norvegicus
395530 Gallus gallus
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