COL4A1 Protein (AA 30-167, partial) (GST tag)
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- Target See all COL4A1 Proteins
- COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 30-167, partial
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This COL4A1 protein is labelled with GST tag.
- Application
- SDS-PAGE (SDS), ELISA
- Sequence
- GCAGSGCGKC DCHGVKGQKG ERGLPGLQGV IGFPGMQGPE GPQGPPGQKG DTGEPGLPGT KGTRGPPGAS GYPGNPGLPG IPGQDGPPGP PGIPGCNGTK GERGPLGPPG LPGFAGNPGP PGLPGMKGDP GEILGHVP
- Characteristics
- Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Ref.12 Ref.17 Ref.18 Ref.19 Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin
- Purity
- 90 %
- Top Product
- Discover our top product COL4A1 Protein
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- Comment
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Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS buffer, 20mM GSH
- Storage
- -20 °C
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- Target
- COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))
- Alternative Name
- Collagen alpha-1(IV) chain (COL4A1 Products)
- Synonyms
- col4a1 Protein, wu:fc02g11 Protein, HANAC Protein, ICH Protein, POREN1 Protein, arresten Protein, Bru Protein, Col4a-1 Protein, Del(8)44H Protein, Raw Protein, Svc Protein, collagen, type IV, alpha 5 (Alport syndrome) Protein, collagen type IV alpha 1 chain Protein, collagen, type IV, alpha 1 Protein, col4a5 Protein, COL4A1 Protein, Col4a1 Protein
- Molecular Weight
- 40.3 kD
- UniProt
- P02462
- Pathways
- Skeletal Muscle Fiber Development, Growth Factor Binding
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