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Browse our anti-Lin-28 Homolog A (C. Elegans) (LIN28A) Antibodies

Full name:
anti-Lin-28 Homolog A (C. Elegans) Antibodies (LIN28A)
On www.antibodies-online.com are 163 Lin-28 Homolog A (C. Elegans) (LIN28A) Antibodies from 27 different suppliers available. Additionally we are shipping Lin-28 Homolog A (C. Elegans) Kits (18) and Lin-28 Homolog A (C. Elegans) Proteins (18) and many more products for this protein. A total of 208 Lin-28 Homolog A (C. Elegans) products are currently listed.
Synonyms:
AL024421, CSDD1, ENSMUSG00000070700, Gm10299, Lin-28, lin-28A, LIN28, RGD1566408, sb:cb650, Tex17, ZCCHC1, zgc:55584
list all antibodies Gene Name GeneID UniProt
LIN28A 298542  
LIN28A 79727 Q9H9Z2
LIN28A 83557 Q8K3Y3

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Most Popular Reactivities for anti-Lin-28 Homolog A (C. Elegans) (LIN28A) Antibodies

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All available anti-Lin-28 Homolog A (C. Elegans) Antibodies

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Top referenced anti-Lin-28 Homolog A (C. Elegans) Antibodies

  1. Human Monoclonal LIN28A Primary Antibody for IF, IHC (p) - ABIN387790 : Peng, Maihle, Huang: Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer. in Oncogene 2010 (PubMed)
    Show all 5 references for ABIN387790

  2. Human Polyclonal LIN28A Primary Antibody for FACS, WB - ABIN655496 : Qiu, Ma, Wang, Peng, Huang: Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells. in Nucleic acids research 2010 (PubMed)
    Show all 5 references for ABIN655496

  3. Mouse (Murine) Polyclonal LIN28A Primary Antibody for FACS, IF - ABIN655156 : Iliopoulos, Hirsch, Struhl: An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. in Cell 2009 (PubMed)
    Show all 5 references for ABIN655156

  4. Human Polyclonal LIN28A Primary Antibody for EIA, FACS - ABIN953173 : West, Viswanathan, Yabuuchi, Cunniff, Takeuchi, Park, Sero, Zhu, Perez-Atayde, Frazier, Surani, Daley: A role for Lin28 in primordial germ-cell development and germ-cell malignancy. in Nature 2009 (PubMed)
    Show all 5 references for ABIN953173

  5. Human Polyclonal LIN28A Primary Antibody for EIA, FACS - ABIN953174 : Heo, Joo, Kim, Ha, Yoon, Cho, Yeom, Han, Kim: TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. in Cell 2009 (PubMed)
    Show all 5 references for ABIN953174

  6. Human Polyclonal LIN28A Primary Antibody for WB - ABIN783322 : Heo, Joo, Cho, Ha, Han, Kim: Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. in Molecular cell 2008 (PubMed)
    Show all 3 references for ABIN783322

  7. Human Monoclonal LIN28A Primary Antibody for ICC, ELISA - ABIN968936 : Gerecht-Nir, Dazard, Golan-Mashiach, Osenberg, Botvinnik, Amariglio, Domany, Rechavi, Givol, Itskovitz-Eldor: Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells. in Developmental dynamics : an official publication of the American Association of Anatomists 2005 (PubMed)
    Show all 2 references for ABIN968936

  8. Human Polyclonal LIN28A Primary Antibody for EIA, IHC (p) - ABIN500176 : Ambros: A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans. in Cell 1989 (PubMed)

  9. Cow (Bovine) Polyclonal LIN28A Primary Antibody for IHC, WB - ABIN2775818 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)

More Antibodies against Lin-28 Homolog A (C. Elegans) Interaction Partners

Human Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. The molecular dynamics simulations suggest that a conserved structural feature of the loop regions of pre-let-7 miRNAs is more important for LIN28 recognition than sequence conservation among members of the let-7 family or the presence of the GGAG motif in the 3' region.

  2. Lin28A is up-regulated in 73.3 % of colon cancer patients. Lin28A-enforced expression in colon cancer cells enhanced the chemosensitivity of cancer cells to 5-FU via promoting apoptosis in a let-7 independent manner, associated with decreasing the expression of DNA damage repair protein H2AX.

  3. Upregulation of let-7a carries the potential to reverse CCL18 (show CCL18 Antibodies) induced cell proliferation and migration alteration in breast cancer cells by regulating Lin28 expression.

  4. Data suggest that the Lin28/let-7 (lin-28 homolog protein/mirnlet7 microRNA) molecular switch plays roles in regulation of cell growth signaling pathways and in regulation of expression of metabolic enzymes. [REVIEW]

  5. Lin28A expression promotes metabolic switching to a phenotype that relies predominantly on glycolysis as an energy source, while compromising oxidative phosphorylation.

  6. high LIN28 expressing ovarian cancer cells secrete exosomes that can be taken up by nontumor cells and cause changes in gene expression and cell behavior associated with tumor development. IGROV1

  7. data document the expression profiles of the Lin28/let-7 system in rat testis along postnatal/pubertal maturation, and their perturbation in models of pubertal and hormonal manipulation

  8. The role of Lin28 in cancer and immunity. [Review]

  9. Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts.

  10. Our findings suggest that Lin28 plays a key role in the acquisition of resistance to AR-targeted therapies by prostate cancer cells and establish the importance of Lin28 in prostate cancer progression.

Cow (Bovine) Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. Lin28 pseudogenes do not acquire patterns of tissue-specific methylation as for the parental gene, but rather are methylated in patterns specific to the local genomic environment into which they were inserted.

Mouse (Murine) Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. MAPK/ERK (show MAPK1 Antibodies) directly impacts LIN28, defining an axis that connects signalling, post-transcriptional gene control, and cell fate regulation.

  2. Sirt1 (show SIRT1 Antibodies) knockdown abolished the protective effects of Lin28a against cardiac remodeling and dysfunction after MI, and Lin28a failed to increase the numbers of GFP-LC3 (show MAP1LC3A Antibodies)-positive punctae and decrease aggresome and p62 (show GTF2H1 Antibodies) accumulation in Sirt1 (show SIRT1 Antibodies)-knockdown neonatal cardiomyocytes subjected to hypoxia-induced injury.

  3. data point toward a complex system of regulation by Lin28a, Lin28b (show LIN28B Antibodies), and let-7, in which Lin28b (show LIN28B Antibodies) and let-7 can impact both puberty and growth in a sex-specific manner

  4. Lin28A binds active promoters and recruits Tet1 (show TET1 Antibodies) to regulate gene expression via epigenetic DNA modifications.

  5. Lin28a protects against DCM through PKA/ROCK2 (show ROCK2 Antibodies) dependent pathway.

  6. Lin28B (show LIN28B Antibodies) upregulation in a mouse model does not affect neuroblast proliferation, ganglion size, and Let-7 expression during early postnatal development

  7. Data show that the RNA-binding protein lin28a/microRNA let-7a axis regulated glucose metabolism in part through the insulin (show INS Antibodies)-PI3K-mTOR (show FRAP1 Antibodies) pathway.

  8. Lin28a protects against hypoxia/reoxygenation induced cardiomyocytes apoptosis by alleviating mitochondrial dysfunction under high glucose/high fat conditions

  9. Lin28a overexpression efficiently and specifically reduces let-7 miRNAs and up-regulates let-7 target genes.

  10. Lin28 binds to guanine-rich miRNAs and mRNAs that contain G-quartet structural features and remodels these structures.

Zebrafish Lin-28 Homolog A (C. Elegans) (LIN28A) interaction partners

  1. The knockdown of Lin-28a or Lin-28b (show LIN28B Antibodies) function by morpholino microinjection into embryos resulted in severe cell proliferation defects during early morphogenesis.

  2. The Lin-28 is induced in Muller glia within 6 h following retinal injury and is necessary for Muller glia dedifferentiation.

Lin-28 Homolog A (C. Elegans) (LIN28A) Antigen Profile

Antigen Summary

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).

Alternative names and synonyms associated with Lin-28 Homolog A (C. Elegans) (LIN28A)

  • lin-28 homolog C (C. elegans) (Lin28c) antibody
  • lin-28 homolog A (lin28a) antibody
  • lin-28 homolog (C. elegans) (lin28) antibody
  • RNA-binding protein LIN-28 (lin28) antibody
  • lin-28 homolog A (C. elegans) (LIN28A) antibody
  • lin-28 homolog A (C. elegans) (Lin28a) antibody
  • lin-28 homolog A (C. elegans) (lin28a) antibody
  • AL024421 antibody
  • CSDD1 antibody
  • ENSMUSG00000070700 antibody
  • Gm10299 antibody
  • Lin-28 antibody
  • lin-28A antibody
  • LIN28 antibody
  • RGD1566408 antibody
  • sb:cb650 antibody
  • Tex17 antibody
  • ZCCHC1 antibody
  • zgc:55584 antibody

Protein level used designations for LIN28A

lin-28A , protein lin-28 homolog A , lin-28 homolog , RNA-binding protein LIN-28 , lin-28 homolog A (C. elegans) , lin-28-like , RNA-binding protein LIN-28A , zinc finger CCHC domain-containing protein 1 , zinc finger, CCHC domain containing 1 , testis expressed gene 17 , testis-expressed protein 17 , Lin-28.1 , RNA-binding protein lin-28

GENE ID SPECIES
298542 Rattus norvegicus
548523 Xenopus (Silurana) tropicalis
549020 Xenopus (Silurana) tropicalis
100012320 Monodelphis domestica
100071098 Equus caballus
100302344 Ovis aries
100379627 Felis catus
387262 Xenopus laevis
79727 Homo sapiens
612162 Canis lupus familiaris
100142662 Sus scrofa
614997 Bos taurus
83557 Mus musculus
500562 Rattus norvegicus
456661 Pan troglodytes
428206 Gallus gallus
394066 Danio rerio
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