Browse our anti-Nucleoporin 98kDa (NUP98) Antibodies

On are 66 Nucleoporin 98kDa (NUP98) Antibodies from 15 different suppliers available. Additionally we are shipping Nucleoporin 98kDa Kits (18) and Nucleoporin 98kDa Proteins (10) and many more products for this protein. A total of 101 Nucleoporin 98kDa products are currently listed.
4732457F17, ADIR2, AI849286, CG10198, CG10201, Dmel\\CG10198, GB12688, im:7151238, l(3)95BCd, Nup-98, Nup 96, NUP96, NUP98, Nup 98, nup98-96, Nup98-Nup96, Nup98/96, nup145, NUP196, zgc:63593, zgc:113968
list all antibodies Gene Name GeneID UniProt
NUP98 269966  
NUP98 81738 P49793
NUP98 4928 P52948

Most Popular Reactivities for anti-Nucleoporin 98kDa (NUP98) Antibodies

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anti-Human Antibodies:

All available anti-Nucleoporin 98kDa Antibodies

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More Antibodies against Nucleoporin 98kDa Interaction Partners

Fruit Fly (Drosophila melanogaster) Nucleoporin 98kDa (NUP98) interaction partners

  1. Nup98 provides a scaffold for poised genes and mediates Induced enhancer-promoter contacts in genetic transcription.

  2. Nup98 associates and colocalizes with the MBD (show DPEP1 Antibodies)-R2/NSL and Trx (show GSR Antibodies) complexes. Nup98 regulates transcription of Trx (show GSR Antibodies) targets, the Hox (show MSH2 Antibodies) genes.

  3. Nup98, a virus-induced gene, was antiviral against a panel of viruses.

  4. Study analyzed genomic interactions of full-length nucleoporins Nup98, Nup50 (show NUP50 Antibodies), and Nup62 and found that they predominantly interacted with active genes inside the nucleoplasm, particularly those involved in developmental regulation and the cell cycle.

  5. Nup88 (show NUP88 Antibodies) localizes to silent loci, Sec13 (show SEC13 Antibodies), Nup98, and a subset of FG-repeat nucleoporins bind to developmentally regulated genes undergoing transcription induction.

Mouse (Murine) Nucleoporin 98kDa (NUP98) interaction partners

  1. We demonstrated that Nup98-TopIIbeta and Nup98-SETBP1 (show SETBP1 Antibodies) negatively regulate the XPO1 (show XPO1 Antibodies)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis.

  2. The age-associated accumulation of somatic mutations that occurs in the Nup98-HOXD13 (show HOXD13 Antibodies) (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR (show EIF2AK2 Antibodies) transgene.

  3. Nup50 (show NUP50 Antibodies) dynamics are independent of importin alpha, Nup153 (show NUP153 Antibodies), and Nup98, even though the latter two proteins also exhibit transcription-dependent mobility.

  4. Data indicate that loss of cyclin-dependent kinase inhibitor p15 (p15Ink4b (show CDKN2B Antibodies)) collaborates with oncogene (show RAB1A Antibodies) fusion protein Nup98-HoxD13 (show HOXD13 Antibodies) transgene in the development of predominantly myeloid neoplasms.

  5. Homeobox (show PRRX1 Antibodies) partners create more potent NUP98 fusion oncogenes than do non-homeobox (show PRRX1 Antibodies) partners.

  6. findings show that expression of NUP98-HOXD13 (show HOXD13 Antibodies) impairs class switch recombination and reduces the antibody-mediated immune response, in addition to its role in leukemia

  7. Mice expressing both the FLT3 (show FLT3 Antibodies)/ITD and Nup98-HoxD13 (show HOXD13 Antibodies) (NHD13) fusion gene developed acute myeloid leukemia (show BCL11A Antibodies) with 100% penetrance

  8. Data show that NUP98-HOXA10HD, a novel, canonical NUP98-Hox (show MSH2 Antibodies) fusion, significantly enhances the self-renewal capacity of hematopoietic stem cells.

  9. These results clearly demonstrate that Nup98 functions as a novel shuttling cofactor for Crm1 (show XPO1 Antibodies)-mediated nuclear export in conjunction with RanBP3 (show RANBP3 Antibodies).

  10. A mouse model of CML blast crisis induced by cooperation between BCR/ABL (show ABL1 Antibodies) and NUP98/HOXA9 (show HOXA9 Antibodies)

Zebrafish Nucleoporin 98kDa (NUP98) interaction partners

  1. data show that a novel nup98 was identified and it serves a role in nucleocytoplasmic trafficking similar to human NUP98.

Human Nucleoporin 98kDa (NUP98) interaction partners

  1. DYNLT1 (show DYNLT1 Antibodies) interacts with nucleoporins and plays a role in the dysregulation of gene expression and induction of hematopoietic cell proliferation by the leukemogenic nucleoporin (show AGFG2 Antibodies) fusion, NUP98-HOXA9 (show HOXA9 Antibodies)

  2. the mutation order in the NUP98-rearranged pediatric AML (show RUNX1 Antibodies) begins with the NUP98 rearrangement leading to epigenetic dysregulations then followed by mutations of critical hematopoietic transcription factors and finally, activation of the FLT3 (show FLT3 Antibodies) signaling pathway.

  3. These results provide novel insight into the mechanisms underlying the aberrant capability of NUP98 oncoproteins to interact with APC (show APC Antibodies)/C(Cdc20 (show CDC20 Antibodies)) and to interfere with its function.

  4. Our results suggest that NA10HD increases the number of gamma-globin-transduced HSCs that engraft, leading to an elevated number of fetal hemoglobin-containing red cells.

  5. NUP98-HOXA9 (show HOXA9 Antibodies) ability to induce blood cell expansion is evolutionarily conserved.

  6. The study demonstrated the association of NUP98-IQCG with CRM1 (show XPO1 Antibodies), and found that NUP98-IQCG expression inhibits the CRM1 (show XPO1 Antibodies)-mediated nuclear export of p65 (show GORASP1 Antibodies) and enhances the transcriptional activity of nuclear factor-kappaB. Moreover, IQCG could be entrapped in the nucleus by NUP98-IQCG, and the fusion protein interacts with calmodulin (show CALM1 Antibodies) via the IQ motif in a calcium-independent manner.

  7. The results indicate that highly selective targeting of Nup98-fusion proteins to Hox (show MSH2 Antibodies) cluster regions via prebound Crm1 (show XPO1 Antibodies) induces the formation of higher order chromatin structures that causes aberrant Hox (show MSH2 Antibodies) gene regulation.

  8. Despite the difference in localization, all tested Nup98 chimera provoked morphological alterations in the nuclear envelope (NE), in particular affecting the nuclear lamina and the lamina-associated polypeptide 2alpha.

  9. NUP98-HOXA9 (show HOXA9 Antibodies) expression induces myeloid disease.

  10. Overall, these results demonstrate a novel role for FOXK1 (show FOXK2 Antibodies) in regulating the expression of antiviral genes via Nup98, from insects to humans.

Xenopus laevis Nucleoporin 98kDa (NUP98) interaction partners

  1. These data support a model in which Nup98 interacts with microtubules and antagonizes MCAK (show KIF2C Antibodies) activity, thus promoting bipolar spindle assembly.

Nucleoporin 98kDa (NUP98) Antigen Profile

Antigen Summary

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described.

Alternative names and synonyms associated with Nucleoporin 98kDa (NUP98)

  • Nucleoporin 98-96 (Nup98-96) antibody
  • nucleoporin 98kDa (Nup98) antibody
  • nucleoporin 98kDa (NUP98) antibody
  • nucleoporin 98 (Nup98) antibody
  • nucleoporin 98 (nup98) antibody
  • Nup98 protein (nup98) antibody
  • 4732457F17 antibody
  • ADIR2 antibody
  • AI849286 antibody
  • CG10198 antibody
  • CG10201 antibody
  • Dmel\\CG10198 antibody
  • GB12688 antibody
  • im:7151238 antibody
  • l(3)95BCd antibody
  • Nup-98 antibody
  • Nup 96 antibody
  • NUP96 antibody
  • NUP98 antibody
  • Nup 98 antibody
  • nup98-96 antibody
  • Nup98-Nup96 antibody
  • Nup98/96 antibody
  • nup145 antibody
  • NUP196 antibody
  • zgc:63593 antibody
  • zgc:113968 antibody

Protein level used designations for NUP98

CG10198-PA , CG10198-PC , CG10198-PD , Nup98 , Nup98-96-PA , Nup98-96-PC , Nup98-96-PD , nucleoporin 98 , nucleoporin 98-96 , nucleoporin98-96 , nucleoporin 98kD , nucleoporin 98kDa , nuclear pore complex protein Nup98-Nup96-like , nuclear pore complex protein Nup98-Nup96 , 98 kDa nucleoporin , nuclear pore complex protein Nup98 , nucleoporin Nup98 , GLFG-repeat containing nucleoporin , Nup98-Nup96

42816 Drosophila melanogaster
408335 Apis mellifera
450971 Pan troglodytes
587580 Strongylocentrotus purpuratus
100016427 Monodelphis domestica
100052986 Equus caballus
100090367 Ornithorhynchus anatinus
100414799 Callithrix jacchus
100475098 Ailuropoda melanoleuca
100522560 Sus scrofa
269966 Mus musculus
81738 Rattus norvegicus
777756 Danio rerio
430616 Gallus gallus
4928 Homo sapiens
476822 Canis lupus familiaris
540004 Bos taurus
100343626 Oryctolagus cuniculus
446233 Xenopus laevis
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