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Human OCT4 Protein expressed in HEK-293 Cells - ABIN2727872
Soufi, Garcia, Jaroszewicz, Osman, Pellegrini, Zaret: Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming. in Cell 2015
Studies suggest that embryonic signaling pathways, the likes of Notch (show NOTCH1 Proteins), Wnt (show WNT2 Proteins), and Hedgehog (show SHH Proteins) and tumor marker Oct-4 offer targets for cascade-specific molecular inhibition as they are fundamental to (cancer and normal) stem cell maintenance and growth.
The quadruplex acts as a strong, positive regulator of Oct4 expression.
these findings demonstrated that HIF-2alpha (show EPAS1 Proteins) in vselMSCs cooperated with Oct4 in survival and function. The identification of the cooperation between HIF-2alpha (show EPAS1 Proteins) and Oct4 will lead to deeper characterization of the downstream targets of this interaction in vselMSCs and will have novel pathophysiological implications for the repair of infarcted myocardium.
gene editing reveals a role for OCT4 in human embryogenesis
we are reporting a new variant of OCT4, which is expressed under different physiological conditions. The finding shed more light on complexity of OCT4 expression and functions.
High Oct4 expression is associated with breast cancer.
The expression of Oct4A may be crucial to promote and sustain integrin-mediated extracellular matrix (ECM (show MMRN1 Proteins)) remodeling requisite for tumor metastasis in ovarian cancer patients.
High OCT3 expression is associated with ovarian cancer.
Endogenous Plastic Somatic (ePS) cells in a latent state, i.e. lacking SOX2 (show SOX2 Proteins), OCT3/4 and NANOG (show NANOG Proteins) (SON) expression, in non-diseased breast specimens through immunohistochemical analysis of previously identified ePS-specific biomarkers (CD73(+), EpCAM (show EPCAM Proteins)(+) and CD90 (show THY1 Proteins)(-)).
BORIS (show CTCFL Proteins) is associated with the cancer stem cell-like traits of human liver cancer cells through the epigenetic regulation of OCT4.
Activin A (show INHBA Proteins) and overexpression of SMAD2 (show SMAD2 Proteins)/3 significantly promoted expressions of porcine NANOG (show NANOG Proteins) and OCT4,maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (show NANOG Proteins)/OCT4 expression.
Our results indicate that continuous expression of OCT-4 in blastomeres is essential for trophectoderm formation of porcine embryos.
These findings suggest that the 12-bp indel polymorphism of the Oct4 gene might be a potential DNA marker for selecting preferred individuals in relation to reproductive traits in pig marker-assisted selection breeding.
Oct4-overexpression enhances porcine ovarian stem cell differentiation in to oocyte-like cells.
showed novel molecular regulation of CDX2 (show CDX2 Proteins) on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 (show CDX2 Proteins) and Oct4 in embryo of mammals other than mouse
Overexpression of Sox2 (show SOX2 Proteins) or Oct4 in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Proteins) results in higher proliferation and differentiation compared to controls.
Oct4 positive stem/progenitor swine lung epithelial cells are targets for influenza virus replication.
study shows that localization of octamer-binding protein 4(OCT4) is associated with an embryonic stem cell (ESC)-like morphology from porcine inner cell mass
OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level.
we concluded that OCT4 expression in somatic cells is not a good prognosis marker for selecting cell lines.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Oct4 exhibited significant hypermethylation in sperm compared with that in oocytes
In contrast to protein distribution, regulation of Oct4 transcription is conserved between mammalian species.
analysis of CpG islands of bovine Leptin (show LEP Proteins) and POU5F1 genes in cloned bovine fetuses
The restoration of pluripotency can be directly observed in living cells or SCNT embryos from such Pou5f1-EGFP transgenic fetuses.
sequences of mRNA and translated protein of the newly identified genes and those of POU5F1 were aligned to their mammalian orthologs to determine the degree of evolutionary conservation
Higher values of OCT-4 expression were observed in embryos and endometrial tissue in females reproduced under heat conditions.
protein expression during rabbit embryonic development: investigation of temporal and spatial relationship of expression of Oct-4, Cdx-2 (caudal type homeobox transcription factor 2 (show CDX2 Proteins)) and histone H4 (acetylated at lysine 5) in morula/blastocysts
The signal may have reflected the regulation of Oct-4 through enhancer switching and therefore may be related to cell lineage formation in rabbit embryos.
The POU5F1 gene is strictly regulated during early embryo development.
Cytoplasmic CD44 (show CD44 Proteins) and absence of nuclear Oct3/4 suggest that the cells of cardiac sarcomas may represent 'daughter' stem cells that no longer have the capacity for tumour initiation, but have subsequently developed new lines of partial differentiation.
Lack of restricted OCT4 protein, and inner cell mass localization of NANOG in primate blastocysts, suggests that NANOG may determine inner cell mass fate more specifically during primate development.
PRDM14 (show PRDM14 Proteins) recruited OCT3/4 to the enhancer regions of naive pluripotency genes via TET-base excision repair-mediated demethylation.
High POU5F1 expression is associated with disruption in differentiation and spermatogenesis.
Three regulating complexes centered by Sox2 (show SOX2 Proteins)-Oct4, Nanog (show NANOG Proteins), and Lrh1 (show NR5A2 Proteins) maintain Oct4 expression in pluripotent stem cells in mice. [review]
OCT4 is an integral and necessary component of signal-regulated transcriptional processes required for tissue-specific responses.
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4, Sox2 (show SOX2 Proteins), and Nanog (show NANOG Proteins); Trim24 (show TRIM24 Proteins) significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
ATOX1 (show ATOX1 Proteins) appeared ubiquitously expressed throughout the cells until compaction; in subsequent embryo stages, ATOX1 (show ATOX1 Proteins) relocalized to cytoplasmic perinuclear domains in the inner cell mass. Silencing of Oct4 did not affect Atox1 (show ATOX1 Proteins) expression, but silencing of Atox1 (show ATOX1 Proteins) at the 2-cell stage strongly diminished Oct4 expression in 16-cell embryos.
smooth muscle cell (SMC (show DYM Proteins))-specific conditional knockout of Oct4 in Apoe (show APOE Proteins)-/- mice resulted in increased lesion size and changes in lesion composition that are consistent with decreased plaque stability, including a thinner fibrous cap, increased necrotic core area, and increased intraplaque hemorrhage.
In mouse model of acute uterine injury, Nanog (show NANOG Proteins) homebox (NANOG (show NANOG Proteins)) expression reached a peak at 6 h, while sex-determining region Y (show SRY Proteins)-box2 (SOX2 (show SOX2 Proteins)) and octamer-binding protein 4 (OCT4) peaked later at 12 h after lipopolysaccharide (LPS (show TLR4 Proteins)) treatment.
Here, the authors present the first structure of mouse GCNF (show NR6A1 Proteins) DNA-binding domain in complex with the Oct4 DR0. The overall structure revealed two molecules bound in a head-to-tail fashion on opposite sides of the DNA at a DR0 motif located within the Oct4 promoter.
Data show that expression of the Oct-4, Sox2 (show SOX2 Proteins), Klf4 (show KLF4 Proteins), and c-Myc (show MYC Proteins) (OSKM) reprogramming factors induces Cyclin D1 (show CCND1 Proteins) expression, and the increased Cyclin D1 (show CCND1 Proteins) expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
Data suggest that, in developing gastrula, Znfl1 controls developmental gene expression of Hoxb1b in embryonic posterior neuroectoderm by acting upstream of Pou5f3 and Sall4 (show SALL4 Proteins); these proteins appear to be involved in neurogenesis. (Znfl1 = zinc finger-like gene 1; Hoxb1b = homeobox B1b protein; Pou5f3 = POU domain class 5 transcription factor 3 (show TCF3 Proteins); Sall4 (show SALL4 Proteins) = spalt-like transcription factor 4 (show TCF4 Proteins))
Regulation of mych by Pou5f1 appears to be direct transcriptional activation.
The posttranslational modification by phosphorylation opens the possibility that Pou5f1 may be subject to temporal or region specific modulation of its activity or stability by embryonic signaling mechanisms.
discuss mechanistic implications of simultaneous activation of transcriptional targets by ubiquitous, like Pou5f1, and region-specific inducers, emerging as a common regulatory motif in early development
maternal Nanog (show NANOG Proteins), Pou5f1 and SoxB1 are required to initiate the zygotic developmental program and induce clearance of the maternal program by activating miR (show MYLIP Proteins)-430 expression
thses data position Pou5f1 and SOX (show PIPOX Proteins)-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control.
The defects due to HEP induction were rescued by introducing wild-type pou2 mRNA before the heat treatments.
Vox plays a key role downstream of BMP signals in regulating the capacity of Nodal to induce endoderm versus mesoderm by modulating the activity of the Casanova/Pou2 regulatory system.
Pou2 functions in multiple aspects of vertebrate development, especially in the binary decision of the mesendoderm to mesoderm and endoderm in different ways depending on the developmental stage.
show that Pou5f1 binds to phylogenetically conserved Oct (show Plxna2 Proteins)/Pou5f1 sites in the vox promoter, both in vivo and in vitro
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6\;22)(p21\;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
POU domain transcription factor OCT4
, POU domain, class 5, transcription factor 1
, POU-type homeodomain-containing DNA-binding protein
, octamer-binding protein 3
, octamer-binding protein 4
, octamer-binding transcription factor 3
, octamer-binding transcription factor-3
, POU class 5 homeobox 1
, POU domain, class 5, transcription factor 1-like
, POU domain class 5 transcription factor 1
, POU domain gene 2
, spiel ohne grenzen
, spiel ohne grenzen/pou2
, octamer binding transcription factor 4
, Octamer-binding transcription factor 3
, octamer-binding transcription factor 4