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G9a (show EHMT2 Proteins) promotes H3K27 methylation of the E-cadherin (show CDH1 Proteins) promoter by upregulating PCL3 to increase PRC2 promoter recruitment and by downregulating the H3K27 demethylase (show MBD2 Proteins) KDM7A to silence E-cadherin (show CDH1 Proteins) gene
These results provide evidence that PHF19 promotes Hepatocellular carcinoma and is regulated by the tumor-suppressor, miR (show MLXIP Proteins)-195-5p
The histone H3K36me3 binding by the Tudor domains of PHF1 (show PHF1 Proteins), PHF19 and likely MTF2 (show MTF2 Proteins) provide another recruitment and regulatory mechanism for the PRC2 complex
propose a model whereby PHF19 functions during mouse embryonic stem cell differentiation to transiently bind the H3K36me3 mark via its Tudor domain
PHF19 silencing reduces the cell proliferation rate and increases the transendothelial migration capacities of melanoma cell lines.
Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 (show EZH2 Proteins) protein complexes
identification of a gene encoding a human homologue of the Drosophila polycomblike protein, hPCL3 gene, encoding two nuclear proteins, hPCL3S and hPCL3L; markedly overexpressed in many types of cancers
Acts as a transcritpional repressor. Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
PHD finger protein 19
, PHD finger protein 19-like
, polycomb like 3
, polycomb-like 3
, polycomb-like protein 3
, tudor domain containing 19B