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Salvador Homolog 1 (Drosophila) Proteins (SAV1)
On are 5 Salvador Homolog 1 (Drosophila) (SAV1) Proteins from 4 different suppliers available. Additionally we are shipping SAV1 Antibodies (56) and SAV1 Kits (3) and many more products for this protein. A total of 69 SAV1 products are currently listed.
1700040G09Rik, Salv, Sav, WW45, Wwp3, Wwp4
list all proteins Gene Name GeneID UniProt
SAV1 60485 Q9H4B6
SAV1 64010 Q8VEB2
SAV1 299116 A4V8B4

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Human Salvador Homolog 1 (Drosophila) (SAV1) interaction partners

  1. using an Mst2 (show STK3 Proteins) mutation that disrupts homotypic dimerization, we showed that the monomeric Mst2 (show STK3 Proteins)-SARAH domain could form a stable complex of 1:1 stoichiometric ratio with WW45 refolded under acidic pH.

  2. MST1/2-SAV1 associates with the NPHP transition-zone complex, promoting ciliary localization of multiple ciliary cargoes.

  3. Mst2 (show STK3 Proteins) and the Ser (show SIGLEC1 Proteins)-3 residue of human WW45 function independently of each other in the regulation of the stability of human WW45.

  4. We also confirmed the interaction of HAX-1 (show HAX1 Proteins) and hSav1 in mammalian cells.

  5. downregulation of SAV1 and the consequent YAP1 (show YAP1 Proteins) activation are involved in the pathogenesis of high-grade clear cell renal cell carcinoma (show MOK Proteins).

  6. MST (show MAP3K10 Proteins) and hSAV act as novel co-regulators of ERalpha (show ESR1 Proteins) and may play an important role in breast cancer pathogenesis.

  7. hSav1 interacts with HAX1 (show HAX1 Proteins) and attenuates its protective role against apoptosis in MCF-7 breast cancer cells.

  8. a role for Salvador as a human tumor suppressor and RASSF1A (show RASSF1 Proteins) effector and show that Salvador allows RASSF1A (show RASSF1 Proteins) to modulate p73 (show TP73 Proteins) independently of the hippo pathway.

  9. Study reports that two Hippo pathway components, Mst2 and the scaffold protein hSav1, directly interact with Nek2A and regulate its ability to localize to centrosomes, and phosphorylate C-Nap1 and rootletin.

  10. hSav1 is a newly identified protein that interacts with Mst1 (show MST1 Proteins) and augments Mst1 (show MST1 Proteins)-mediated apoptosis.

Mouse (Murine) Salvador Homolog 1 (Drosophila) (SAV1) interaction partners

  1. Differentiation of 3T3-L1 cells was augmented by MST2 and SAV1 expression and inhibited by knockdown of MST1/2 or SAV1.

  2. In this study, they investigated epigenetic characteristics of WW45+/- mice, evaluating time-dependent changes from prior to the onset of tumorigenesis to hepatocarcinoma.

  3. show that mice with liver-specific ablation of WW45 (a homolog of Drosophila Salvador and adaptor for the Hippo kinase) manifest increased liver size and expansion of hepatic progenitor cells (oval cells) and eventually develop hepatomas.

  4. show using a conditional allele of sav1, that an adaptor that potentiates mst1 (show MST1 Proteins) and mst2 (show STK3 Proteins) activity is likewise required to suppress growth in the mature liver and to prevent tumor formation.

  5. While typical WW domains function as monomeric modules that recognize proline-rich sequences, by using conserved residues that are solvent-exposed on the surface of the beta-sheet, this WW domain buries these residues in the dimer interface.

  6. Mice lacking WW45 reveal a crucial role for WW45 in cell-cycle exit and epithelial terminal differentiation.

SAV1 Protein Profile

Protein Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

Alternative names and synonyms associated with SAV1

  • salvador homolog 1 (Drosophila) (SAV1)
  • salvador homolog 1 (Drosophila) (Sav1)
  • 1700040G09Rik protein
  • Salv protein
  • Sav protein
  • WW45 protein
  • Wwp3 protein
  • Wwp4 protein

Protein level used designations for SAV1

1700040G09Rik , 45 kDa WW domain protein , WW domain-containing , hWW45 , protein salvador homolog 1 , WW domain-containing protein 3 , WW domain-containing protein 4 , Salvador homolog 1 protein , rWW45

60485 Homo sapiens
64010 Mus musculus
299116 Rattus norvegicus
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