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An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.
This study demonstrates that OPRM1 (show OPRM1 Proteins) 118A>G and the combined OPRM1 (show OPRM1 Proteins)/COMT genotype are associated with experimental thermal pain sensitivity in a paediatric population.
These data indicate a significant interaction between peripheral proline and COMT genotype, influencing negative symptoms in schizophrenia and bipolar disorder.
159 patients with 22q11.2 Deletion Syndrome (22q11DS) were analyzed for a potential association between intelligence quotient (IQ) and COMT genotype; no correlation between COMT genotype and IQ performance was found
Study provides support for the argument that Apolipoprotein E (APOE (show APOE Proteins) varepsilon4+) and catechol-O-methyl transferase Met/Met genotypes can be used as predictors of faster cognitive decline in Parkinson's disease.
Study measured smooth pursuit in 110 healthy subjects genotyped for two well-documented polymorphisms, the COMT Val(158)Met polymorphism and the SLC6A3 (show SLC6A3 Proteins) 3'-UTR-VNTR polymorphism; found the COMT Val(158)Met polymorphism specifically associated with anticipatory pursuit parameters, emphasizing the dominant impact of prefrontal dopamine activity on complex oculomotor control.
This study did not detect significant differences in cognitive or mood outcomes between patients who have the val66val or met versions of the COMT polymorphism
OMT met allele might be involved in stress regulation during early infancy, especially in response to repeated socio-emotional stress exposure.
Patients carrying both the BDNF (show BDNF Proteins) Val66Val and COMT Met158Met variants had higher alcohol consumption.
Association between COMT genotype and 6-m walk time: Those with higher (Val/Val) and lower (Met/Met) dopamine slowed more over 10 years than those with the intermediate (Met/Val) dopamine. Race differences seen.
This paired case-control study examined the association between COMT gene rs4680 polymorphism and suicide attempts. The G/G genotype was significantly more prevalent in female suicide attempters than their matched controls. Conditional logistic regression showed that the G/G genotype was significantly associated with an increased risk of suicide attempts only for women (odds ratio=2.3; 95% confidence interval: 1.2-4.2)
Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice.
This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Proteins)) and postero-parieto-temporal cortex of male, but not female adult mice.
COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Proteins).
The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
COMT knockout mice were more impulsive compared with wild-type littermates.
Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.
decreased COMT activity was associated with some changes in feeding microstructure in rats and mice
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
, catechol O-methyltransferase, soluble form
, catechol O-methyltransferase, membrane-bound form
, catechol O-methyltransferase
, catechol-O-methyltransferase 1