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Browse our COMT Proteins (COMT)

Full name:
Catechol-O-Methyltransferase Proteins (COMT)
On are 29 Catechol-O-Methyltransferase (COMT) Proteins from 11 different suppliers available. Additionally we are shipping COMT Antibodies (189) and COMT Kits (33) and many more products for this protein. A total of 263 COMT products are currently listed.
comt, Comt1, D16Wsu103e, D330014B15Rik, mb-comt, MGC154444, s-comt
list all proteins Gene Name GeneID UniProt
COMT 1312 P21964
COMT 12846 O88587
COMT 24267 P22734

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COMT Proteins (COMT) by Origin

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Top referenced COMT Proteins

  1. Human COMT Protein expressed in Escherichia coli (E. coli) - ABIN666744 : Cotton, Stoddard, Parson: Oxidative inhibition of human soluble catechol-O-methyltransferase. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN666744

More Proteins for COMT Interaction Partners

Horse (Equine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.

Human Catechol-O-Methyltransferase (COMT) interaction partners

  1. Women with COMT Val/Val genotype are at high risk of developing multiple uterine fibroids either positive or negative for MED12 exon 2 mutations.

  2. we genotyped five hormone-related genes: estrogen receptor-alpha (ESR1 (show ESR1 Proteins)), aromatase (CYP19 (show CYP19A1 Proteins)), catechol-O-methyl transferase (COMT), sex hormone-binding globulin (SHBG (show SHBG Proteins))and glutathione S-transferase (show GSTa2 Proteins) (GSTP1 (show GSTP1 Proteins)). Our data demonstrate that these ESR1 (show ESR1 Proteins), GSTP1 (show GSTP1 Proteins), and CYP19 (show CYP19A1 Proteins) polymorphisms are associated with risk of BC, and the risk haplotype TGGGGTC could help to identify populations with high susceptibility to BC in Chinese women.

  3. No significant differences were found in COMT genotypes, allele frequencies, or haplotypes among migraine patient groups and controls.

  4. No association of functional polymorphisms in the estrogen metabolism genes COMT with menstrual migraine.

  5. genetic association studies in a population in Denmark: Data suggest that, compared to non-carriers of the COMT SNP rs4680 A allele, carriers/heterozygotes (AA/AG) report higher bone pressure pain tolerance threshold (i.e., less pain) by up to 23.8%.

  6. genetic association studies in a population in Denmark: Data suggest that a reduced risk of death in morphine addiction is associated with an SNP in ABCB1 (show ABCB1 Proteins) (P-glycoprotein/ATP-binding cassette subfamily B member 1, rs9282564, AG/TT) and an SNP in COMT (catechol-O-methyltransferase, rs4680, AA) in the population studied.

  7. COMT rs4680 influences individual differences in reward learning.

  8. COMT Val158Met polymorphism is not associated with endometrial and ovarian cancer.

  9. Whether COMT genotype indirectly influences global functional outcome through post-traumatic stress disorder remains to be determined

  10. CYP2E1 (show CYP2E1 Proteins) rs2031920 and COMT rs4680 are not major contributors to lung cancer risk.

Mouse (Murine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Proteins)) and postero-parieto-temporal cortex of male, but not female adult mice.

  2. COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.

  3. COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function

  4. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Proteins).

  5. The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.

  6. Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.

  7. COMT knockout mice were more impulsive compared with wild-type littermates.

  8. Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.

  9. decreased COMT activity was associated with some changes in feeding microstructure in rats and mice

  10. This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice.

COMT Protein Profile

Protein Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Alternative names and synonyms associated with COMT

  • catechol-O-methyltransferase (COMT)
  • catechol-O-methyltransferase (comt)
  • catechol-O-methyltransferase (comt.2)
  • catechol-o-methyltransferase (Rv1703c)
  • catechol-o-methyltransferase (Mb1729c)
  • catechol O-methyltransferase-like (LOC100630273)
  • catechol-O-methyltransferase (Comt)
  • comt protein
  • Comt1 protein
  • D16Wsu103e protein
  • D330014B15Rik protein
  • mb-comt protein
  • MGC154444 protein
  • s-comt protein

Protein level used designations for COMT

catechol-O-methyltransferase , catechol-o-methyltransferase , catechol O-methyltransferase, soluble form , catechol O-methyltransferase, membrane-bound form , catechol O-methyltransferase , O-methyltransferase , catechol-O-methyltransferase 1 , catecholamine-O-methyltransferase

416783 Gallus gallus
458655 Pan troglodytes
549111 Xenopus (Silurana) tropicalis
549911 Xenopus (Silurana) tropicalis
779254 Xenopus laevis
885066 Mycobacterium tuberculosis H37Rv
1092683 Mycobacterium bovis AF2122/97
100033869 Equus caballus
100146509 Equus caballus
100630273 Equus caballus
1312 Homo sapiens
445450 Canis lupus familiaris
12846 Mus musculus
24267 Rattus norvegicus
618278 Bos taurus
100155530 Sus scrofa
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