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Browse our COMT Proteins (COMT)

Full name:
Catechol-O-Methyltransferase Proteins (COMT)
On are 27 Catechol-O-Methyltransferase (COMT) Proteins from 10 different suppliers available. Additionally we are shipping COMT Antibodies (181) and COMT Kits (36) and many more products for this protein. A total of 256 COMT products are currently listed.
comt, Comt1, D16Wsu103e, D330014B15Rik, mb-comt, MGC154444, s-comt
list all proteins Gene Name GeneID UniProt
COMT 1312 P21964
COMT 12846 O88587
COMT 24267 P22734

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COMT Proteins (COMT) by Origin

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Top referenced COMT Proteins

  1. Human COMT Protein expressed in Escherichia coli (E. coli) - ABIN666744 : Cotton, Stoddard, Parson: Oxidative inhibition of human soluble catechol-O-methyltransferase. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN666744

More Proteins for COMT Interaction Partners

Horse (Equine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. An analysis of polymorphisms of the COMT gene as a preliminary step in evaluating the role of the gene in behavior is reported.

Human Catechol-O-Methyltransferase (COMT) interaction partners

  1. Our study findings showed COMT polymorphism conferring risk and GABRA1 (show GABRA1 Proteins) and GABRA2 (show GABRA2 Proteins) polymorphism as a protective genotype for Indian male with alcohol dependence (AD)

  2. COMT genotype was also not predictive of baseline dopamine D1 and D2/3 receptor binding potential.

  3. The results of this study suggest that the severity of poor behaviors among those with PTD (show BCS1L Proteins) is related to COMT Val158Met and Taq1A variation, and these findings are not simply attributable to PTD (show BCS1L Proteins) alone.

  4. This study demonstrated that Regulation of Synaptically Released Dopamine by COMT in the Olfactory Bulb.

  5. High proline levels and a decreased capacity to break down dopamine as a result of the COMT(MET) variant are both relevant in the expression of the social phenotype in patients. This epistatic interaction effect between the COMT(158) genotype and proline on the expression of social deficits in 22q11DS shows how factors other than the direct effects of the deletion itself can modulate the penetrance of behavioural outcomes

  6. A borderline significant association of COMT Val158Met polymorphism and breast density was found.

  7. Review: COMT val158met genotype represents an enticing target for identifying individuals who are more likely to respond positively to dopaminergic drugs.

  8. Clonidine has detrimental effects in subset of chronic fatigue syndrome patients homozygous for COMT rs4680 high activity allele.

  9. Women with vulvodynia had a marginally increased, yet not significant, prevalence of the catechol-O-methyltransferase genotype that is associated with high activity of the coded protein.

  10. Findings from non-IBS studies indicate that the catechol-O-methyltransferase (COMT) Val158Met polymorphism may moderate the efficacy of cognitive behavioral therapy.

Mouse (Murine) Catechol-O-Methyltransferase (COMT) interaction partners

  1. Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice.

  2. This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC (show CFP Proteins)) and postero-parieto-temporal cortex of male, but not female adult mice.

  3. COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.

  4. COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function

  5. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1 (show DTNBP1 Proteins).

  6. The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.

  7. Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.

  8. COMT knockout mice were more impulsive compared with wild-type littermates.

  9. Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased.

  10. decreased COMT activity was associated with some changes in feeding microstructure in rats and mice

COMT Protein Profile

Protein Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Alternative names and synonyms associated with COMT

  • catechol-O-methyltransferase (COMT)
  • catechol-O-methyltransferase (comt)
  • catechol-O-methyltransferase (comt.2)
  • catechol-o-methyltransferase (Rv1703c)
  • catechol-o-methyltransferase (Mb1729c)
  • catechol O-methyltransferase-like (LOC100630273)
  • catechol-O-methyltransferase (Comt)
  • comt protein
  • Comt1 protein
  • D16Wsu103e protein
  • D330014B15Rik protein
  • mb-comt protein
  • MGC154444 protein
  • s-comt protein

Protein level used designations for COMT

catechol-O-methyltransferase , catechol-o-methyltransferase , catechol O-methyltransferase, soluble form , catechol O-methyltransferase, membrane-bound form , catechol O-methyltransferase , O-methyltransferase , catechol-O-methyltransferase 1 , catecholamine-O-methyltransferase

416783 Gallus gallus
458655 Pan troglodytes
549111 Xenopus (Silurana) tropicalis
549911 Xenopus (Silurana) tropicalis
779254 Xenopus laevis
885066 Mycobacterium tuberculosis H37Rv
1092683 Mycobacterium bovis AF2122/97
100033869 Equus caballus
100146509 Equus caballus
100630273 Equus caballus
1312 Homo sapiens
445450 Canis lupus familiaris
12846 Mus musculus
24267 Rattus norvegicus
618278 Bos taurus
100155530 Sus scrofa
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