COMT Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2712474

Product Details

Target: COMT (Catechol-O-Methyltransferase (COMT))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This COMT protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human COMT (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: COMT (Catechol-O-Methyltransferase (COMT))

Alternative Name: Comt (COMT Products)

Synonyms: Comt1 Protein, D16Wsu103e Protein, D330014B15Rik Protein, COMT Protein, mb-comt Protein, s-comt Protein, comt Protein, MGC154444 Protein, zgc:114157 Protein, si:dkey-13a21.15 Protein, zK13A21.15 Protein, zgc:162236 Protein, catechol-O-methyltransferase Protein, microRNA 4761 Protein, catechol-O-methyltransferase S homeolog Protein, methyltransferase Protein, catechol-o-methyltransferase Protein, catechol-O-methyltransferase a Protein, catechol-O-methyltransferase b Protein, catechol O-methyltransferase Protein, COMT Protein, Comt Protein, MIR4761 Protein, comt Protein, comt.2 Protein, comt.S Protein, Rv1703c Protein, Mb1729c Protein, comta Protein, comtb Protein, LOC100354142 Protein

Background: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Molecular Weight: 29.9 kDa

NCBI Accession: NP_000745

Pathways: Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome