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Significant CYP1A1 expression increases over control animals was observed in ileum tissue in swine exposed to a single dose of 10 mgkg-bw-1 PAHs
There was no association between CYP1A1 C genotype and survival in the overall study population
The effect of human chorionic gonadotropin on the activities of cytochrome P-450 CYP1A1, cytochrome P-450 CYP2B1 and methoxyresorufin O-demethylase (MROD) was studied in intact male pigs of 2 breeds.[CYP2B1; MROD]
This study demonstrated for the first time that the serum testosterone level is one of the physiological factors which regulate constitutive expression of hepatic CYP1A1 and CYP1A2 (show CYP1A2 Proteins) in pigs.
The findings demonstrate a gender-related difference in the constitutive expression of hepatic CYP1A1 in Meishan pigs and further indicate that testosterone down-regulates the constitutive gene expression of the enzyme.
Distinct subtypes of urinary bladder epithelial cells with inducible and non-inducible cytochrome P-450 CYP1A1 are reported.
Effect of beta-napthoflavone on AHR (show AHR Proteins)-related gene, CYP1A1, in the pig is reported.
Increased expression of CYP1A1 is associated with ovarian/peritoneal endometriotic lesions.
mtDNA content, methylation of specific loci of mtDNA, and CYP1A1 methylation in placental tissue may serve as molecular signatures for the association between gestational tobacco smoke exposure and low birth weight.
Studied diosmetin effect on signal pathway and apoptosis in HepG2 cells. Dios-induced cell apoptosis could be reversed by p53 (show TP53 Proteins) blockade and the effects of Dios on cellular P53 (show TP53 Proteins) and CYP1A1/CYP1A2 proteins levels were examined. Found P53 (show TP53 Proteins), CYP1A1, and CYP1A2 (show CYP1A2 Proteins) proteins were up-regulated by diosmetin; p53 (show TP53 Proteins) downregulation by pifithrin caused inhibition of apoptosis.
Dependent on composition, mixtures of PAHs activate the AHR (show AHR Proteins) differently through varying transcription responses and expression of CYP1A1/COMT (show COMT Proteins) target genes in granulosa non-tumor and granulosa tumor cell lines.
the CYP1A1 polymorphisms are potential risk factors for digestive tract cancer.
was observed that the variant genotypes of GSTM1 (show GSTM1 Proteins), GSTT1 (show GSTT1 Proteins), GSTP1 (show GSTP1 Proteins) and CYP1A1 did not significantly increase the risk of cervical cancer (CC), however, statistically significant increased risk was observed for women who used wood for cooking and had GSTM1 (show GSTM1 Proteins) (null) genotype.
CYP1A1*2A was not associated with Colorectal Cancer(CRC (show CALR Proteins))development (OR = 1.566; 95% confidence interval [CI] = 0.90-2.73; p = 0.12); C allele-carrying individuals who had smoked within the past 5 years had a significant risk of CRC (show CALR Proteins) (OR = 2.28; 95% CI = 1.07-4.86; p = 0.043).
CYP1A1 polymorphisms were not associated with sporadic colorectal neoplasms.
Allele frequency of the CYP1A1 3801T>C polymorphism does not correlate with semen production as determined by sperm counts or sperm function as determined by fertilization rates with ICSI.
data indicate that CYP1A1 I462V allele confers the least carcinogen-associated genotoxicity, compared to CYP1A1; however, results vary depending on the chemical carcinogen and the genotoxic endpoint
Miroestrol suppressed beta-naphthoflavone increases in CYP1A1.
Taken together, CAPE decreases 3-MC-mediated CYP1A1 expression, and this inhibitory response is associated with inhibition of AhR (show AHR Proteins) and HIF-1alpha (show HIF1A Proteins) induction.
Our results support the hypothesis that CYP1A1 protects against hyperoxic lung injury by decreasing oxidative stress.
CYP1A1 contributes to nitric oxide bioavailability and blood pressure regulation mediated by dietary omega-3 polyunsaturated fatty acids.
Aryl hydrocarbon receptor (show AHR Proteins) mediated induction of hepatic CYP1A1/1A2 is dependent on the presence of ctnnb1 (show CTNNB1 Proteins).
Suggest that CYP1A induction by coplanar polychlorinated/brominated biphenyls depends on AhR (show AHR Proteins) transcriptional activity and not on AhR (show AHR Proteins) expression.
Identify hepatic proteins necessary for the AHR (show AHR Proteins)-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
In livers of HRN mice Cyp1a1, cytochrome b5 (show CYB5A Proteins) and mEH (show EPHX1 Proteins) can effectively activate BaP (show PHB2 Proteins) to DNA binding species, even in the presence of very low amounts of P450 (show POR Proteins) oxidoreductase (show HSD17B6 Proteins).
Reactive oxygen species production contributes to benzo[a]pyrene (BaP (show PHB2 Proteins))-exacerbated atherosclerosis and CYP1A1 plays a protective role against oral BaP (show PHB2 Proteins) toxicity in aorta
harmine and harmaline are promising candidate to inhibit TCDD-mediated induction of Cyp1a1 in mice hepatic and extrahepatic tissues
CYP1A1 and CYP1A2 (show CYP1A2 Proteins) localization into different lipid microdomains is governed by their N-terminal and internal protein regions
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown\; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
cytochrome P450 1A1
, cytochrome P450 CYP1A1
, aryl hydrocarbon hydroxylase
, cytochrome P1-450, dioxin-inducible
, cytochrome P450 form 6
, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
, cytochrome P450-C
, cytochrome P450-P1
, flavoprotein-linked monooxygenase
, xenobiotic monooxygenase
, cytochrome P1-450
, cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c)
, cytochrome P450, 1a1
, cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c)
, cytochrome P450MT2
, microsomal monooxygenase
, aromatic compound inducible
, cytochrome P450 family 1 subfamily a polypeptide 2
, cytochrome P450 subfamily I, polypeptide 1
, cytochrome P450, 1a1, aromatic compound inducible
, P-450 PHPAH1
, P450 LM6
, P450 isozyme 6
, cytochrome P-450 PHPAH1
, cytochrome P450 LM6
, cytochrome P450 isozyme 6