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Browse our CYP3A4 Proteins (CYP3A4)

Full name:
Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Proteins (CYP3A4)
On are 6 Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) Proteins from 5 different suppliers available. Additionally we are shipping CYP3A4 Antibodies (115) and CYP3A4 Kits (34) and many more products for this protein. A total of 164 CYP3A4 products are currently listed.
CP33, CP34, CYP3A, CYP3A3, CYP3A4, CYP3A12, CYP3A21, CYP3A80, CYPIIIA3, CYPIIIA4, CYPIIIA21, HLP, MGC108372, NF-25, P450C3, P450PCN1
list all proteins Gene Name GeneID UniProt
CYP3A4 1576 P08684

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CYP3A4 Proteins (CYP3A4) by Origin

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More Proteins for CYP3A4 Interaction Partners

Horse (Equine) Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

  1. It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Proteins) and cytochrome b(5 (show CYB5A Proteins)).

Human Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

  1. CYP3A4*1G and CYP3A5 (show CYP3A5 Proteins)*3 genetic polymorphisms alter the antihypertensive efficacy of amlodipine in patients with hypertension following renal transplantation.

  2. The CYP3A4 polymorphism A/A+A/G influenced the difference in the mean lymphocyte MN frequency (MNF) & micronucleated cell frequency (MNC). After adjusting risk factors, the MNF level in the MBOCA-exposed workers was 0.520 MN cells/1000 cells higher than the control group among the CYP3A4 A/A+A/G genotype. Similarly, the MNC level in the MBOCA-exposed workers was 0.593 MN/1000 cells higher than the control group.

  3. miR (show MLXIP Proteins)-30c-1-3p was shown to alter the expression of CYP3A4, a prototypical target gene of PXR (show NR1I2 Proteins).

  4. Results show that breast cancer cells resistant to neratinib present an increase expression of CYP3A4 suggesting that increased CYP3A4 activity as a novel mechanism of neratinib resistance.

  5. Results indicate that cytochrome P450 3A4 (CYP3A4) is highly sensitive to the acyl-chain composition of the lipids and fluidity of the membrane in which it is embedded.

  6. The result provides the first direct evidence for an allosteric effect of the peripheral binding site at the protein-membrane interface on the functional properties of CYP3A4.

  7. FGF21 (show FGF21 Proteins)-PXR (show NR1I2 Proteins) signaling pathway may be involved in decreased hepatic CYP3A4 metabolic activity in Nonalcoholic fatty liver disease.

  8. This work applies a new strategy to study cytochrome P450 allostery and supports the hypothesis that substrate binding at the postulated allosteric site of CYP3A4 may induce functional cooperativity.

  9. The possible association of CYP3A5*3 and CYP3A4*1G polymorphisms on CYP3A activity.

  10. activity assays with the human CYP3A4-specific Luciferin isopropyl acetal (Luciferin-IPA) as well as inhibition studies with ketoconazole and CYP3cide were carried out to identify CYP (show PPIG Proteins) activity in zebrafish liver microsomes.

CYP3A4 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with CYP3A4

  • cytochrome P450 3A4 (PTRG_01782)
  • cytochrome P450 3A4 (PTRG_06060)
  • cytochrome P450, family 3, subfamily A, polypeptide 4 (cyp3a4)
  • cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4)
  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 (CYP3A4)
  • cytochrome P450, subfamily IIIA, polypeptide 4 (CYP3A4)
  • CP33 protein
  • CP34 protein
  • CYP3A protein
  • CYP3A3 protein
  • CYP3A4 protein
  • CYP3A12 protein
  • CYP3A21 protein
  • CYP3A80 protein
  • CYPIIIA3 protein
  • CYPIIIA4 protein
  • CYPIIIA21 protein
  • HLP protein
  • MGC108372 protein
  • NF-25 protein
  • P450C3 protein
  • P450PCN1 protein

Protein level used designations for CYP3A4

cytochrome P450 3A4 , cytochrome P450, family 3, subfamily A, polypeptide 4 , cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 , Cytochrome P450 CM3A-10 , cytochrome P450 3A21 , 1,8-cineole 2-exo-monooxygenase , P450-III, steroid inducible , albendazole monooxygenase , albendazole sulfoxidase , cytochrome P450 3A3 , cytochrome P450 HLp , cytochrome P450 NF-25 , cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 , cytochrome P450-PCN1 , glucocorticoid-inducible P450 , nifedipine oxidase , quinine 3-monooxygenase , taurochenodeoxycholate 6-alpha-hydroxylase , cytochrome P450 CYP3A12 , cytochrome P450 3A80

6339762 Pyrenophora tritici-repentis Pt-1C-BFP
6344316 Pyrenophora tritici-repentis Pt-1C-BFP
548503 Xenopus (Silurana) tropicalis
463582 Pan troglodytes
100037189 Xenopus laevis
100294525 Equus caballus
100404344 Callithrix jacchus
100462903 Macaca mulatta
1576 Homo sapiens
479740 Canis lupus familiaris
416477 Gallus gallus
507988 Bos taurus
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