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Browse our CYP3A4 Proteins (CYP3A4)

Full name:
Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Proteins (CYP3A4)
On www.antibodies-online.com are 6 Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) Proteins from 5 different suppliers available. Additionally we are shipping CYP3A4 Antibodies (119) and CYP3A4 Kits (29) and many more products for this protein. A total of 162 CYP3A4 products are currently listed.
Synonyms:
CP33, CP34, CYP3A, CYP3A3, CYP3A4, CYP3A12, CYP3A21, CYP3A80, CYPIIIA3, CYPIIIA4, CYPIIIA21, HLP, MGC108372, NF-25, P450C3, P450PCN1
list all proteins Gene Name GeneID UniProt
CYP3A4 1576 P08684

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CYP3A4 Proteins (CYP3A4) by Origin

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More Proteins for CYP3A4 Interaction Partners

Horse (Equine) Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

  1. It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Proteins) and cytochrome b(5 (show CYB5A Proteins)).

Human Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

  1. Both pazopanib and ketoconazole were docked into the activity cavity of CYP3A4.

  2. data suggested that hepatocyte nuclear factor 4 alpha and glucocorticoid receptor, and epigenetic changes of H3K4me2 and H3K27me3 are associated with the ontogenic expressions of CYP3A4/3A7 in the livers of the Chinese Han population.

  3. The results of this study showed that no significant association between CYP3A5 (show CYP3A5 Proteins)*3 polymorphism and drug-resistance was found.

  4. While CYP2C19 (show CYP2C19 Proteins) genetic polymorphisms significantly affected plasma pantoprazole concentrations, polymorphisms of CYP2C19 (show CYP2C19 Proteins), CYP3A4 and MDR1 did not affect H. pylori eradication rates.

  5. Tamsulosin and tolterodine interfere with CYP3A4 gene expression and activity in an enantiomer-specific way.

  6. amount of sufentanil consumed in general anesthesia of patients with CYP3A4*1G point mutation significantly lower than that in the wild type group

  7. findings suggested that polymorphisms of CYP3A4 gene may be associated with susceptibility to steroid-induced osteonecrosis of the femoral head

  8. These results suggested that CYP3A4 flexibility has a significant influence on the permeation ability of 1,3,7-Trimethyluric Acid.

  9. These results suggest the existence of a marked inter-individual variability regarding the presence of the isoforms of CYP3A. In addition, since sorafenib is metabolized by CYP3A4, but not by CYP3A7 (show CYP3A7 Proteins), an overexpression of CYP3A4 may lead to an increase in the degradation of the drug and then to clinical ineffectiveness.

  10. findings suggest that steroid hormones are able to regulate CYP3A4 mRNA expression, although the circulating levels of these hormones can only regulate control endometrium and not endometriosis tissues, probably because of dysregulated local steroid concentration in these latter samples.

CYP3A4 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with CYP3A4

  • cytochrome P450 3A4 (PTRG_01782)
  • cytochrome P450 3A4 (PTRG_06060)
  • cytochrome P450, family 3, subfamily A, polypeptide 4 (cyp3a4)
  • cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4)
  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 (CYP3A4)
  • cytochrome P450, subfamily IIIA, polypeptide 4 (CYP3A4)
  • CP33 protein
  • CP34 protein
  • CYP3A protein
  • CYP3A3 protein
  • CYP3A4 protein
  • CYP3A12 protein
  • CYP3A21 protein
  • CYP3A80 protein
  • CYPIIIA3 protein
  • CYPIIIA4 protein
  • CYPIIIA21 protein
  • HLP protein
  • MGC108372 protein
  • NF-25 protein
  • P450C3 protein
  • P450PCN1 protein

Protein level used designations for CYP3A4

cytochrome P450 3A4 , cytochrome P450, family 3, subfamily A, polypeptide 4 , cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 , Cytochrome P450 CM3A-10 , cytochrome P450 3A21 , 1,8-cineole 2-exo-monooxygenase , P450-III, steroid inducible , albendazole monooxygenase , albendazole sulfoxidase , cytochrome P450 3A3 , cytochrome P450 HLp , cytochrome P450 NF-25 , cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 , cytochrome P450-PCN1 , glucocorticoid-inducible P450 , nifedipine oxidase , quinine 3-monooxygenase , taurochenodeoxycholate 6-alpha-hydroxylase , cytochrome P450 CYP3A12 , cytochrome P450 3A80

GENE ID SPECIES
6339762 Pyrenophora tritici-repentis Pt-1C-BFP
6344316 Pyrenophora tritici-repentis Pt-1C-BFP
548503 Xenopus (Silurana) tropicalis
463582 Pan troglodytes
100037189 Xenopus laevis
100294525 Equus caballus
100404344 Callithrix jacchus
100462903 Macaca mulatta
1576 Homo sapiens
479740 Canis lupus familiaris
416477 Gallus gallus
507988 Bos taurus
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