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CYP3A4 Protein (Myc-DYKDDDDK Tag)

CYP3A4 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2712775
  • Target See all CYP3A4 Proteins
    CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))
    Protein Type
    Recombinant
    Origin
    • 8
    • 2
    Human
    Source
    • 5
    • 3
    • 2
    HEK-293 Cells
    Purification tag / Conjugate
    This CYP3A4 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human CYP3A4 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product CYP3A4 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))
    Alternative Name
    Cyp3a4 (CYP3A4 Products)
    Synonyms
    CP33 Protein, CP34 Protein, CYP3A Protein, CYP3A3 Protein, CYPIIIA3 Protein, CYPIIIA4 Protein, HLP Protein, NF-25 Protein, P450C3 Protein, P450PCN1 Protein, MGC108372 Protein, CYP3A80 Protein, CYP3A4 Protein, CYP3A21 Protein, CYPIIIA21 Protein, CYP3A12 Protein, cytochrome P450 family 3 subfamily A member 4 Protein, cytochrome P450 family 3 subfamily A member 43 Protein, cytochrome P450 3A4 Protein, cytochrome P450, subfamily IIIA, polypeptide 4 Protein, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 Protein, cytochrome P450, family 3, subfamily A, polypeptide 4 Protein, CYP3A4 Protein, CYP3A43 Protein, PTRG_01782 Protein, PTRG_06060 Protein, cyp3a4 Protein
    Background
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
    Molecular Weight
    57.2 kDa
    NCBI Accession
    NP_059488
    Pathways
    Steroid Hormone Biosynthesis
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