CYP3A4 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2712775

Product Details

Target: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CYP3A4 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human CYP3A4 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Alternative Name: Cyp3a4 (CYP3A4 Products)

Synonyms: CP33 Protein, CP34 Protein, CYP3A Protein, CYP3A3 Protein, CYPIIIA3 Protein, CYPIIIA4 Protein, HLP Protein, NF-25 Protein, P450C3 Protein, P450PCN1 Protein, MGC108372 Protein, CYP3A80 Protein, CYP3A4 Protein, CYP3A21 Protein, CYPIIIA21 Protein, CYP3A12 Protein, cytochrome P450 family 3 subfamily A member 4 Protein, cytochrome P450 family 3 subfamily A member 43 Protein, cytochrome P450 3A4 Protein, cytochrome P450, subfamily IIIA, polypeptide 4 Protein, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 Protein, cytochrome P450, family 3, subfamily A, polypeptide 4 Protein, CYP3A4 Protein, CYP3A43 Protein, PTRG_01782 Protein, PTRG_06060 Protein, cyp3a4 Protein

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 57.2 kDa

NCBI Accession: NP_059488

Pathways: Steroid Hormone Biosynthesis