Browse our DVL1 Proteins (DVL1)

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Dishevelled Segment Polarity Protein 1 Proteins (DVL1)
On are 4 Dishevelled Segment Polarity Protein 1 (DVL1) Proteins from 2 different suppliers available. Additionally we are shipping DVL1 Antibodies (6) and and many more products for this protein. A total of 14 DVL1 products are currently listed.
list all proteins Gene Name GeneID UniProt
DVL1 1855 O14640

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Human Dishevelled Segment Polarity Protein 1 (DVL1) interaction partners

  1. The DEP domain of Dishevelled (show DVL2 Proteins) undergoes a conformational switch, from monomeric to swapped dimer, to trigger DIX domain-dependent polymerization and signaling to beta-catenin (show CTNNB1 Proteins).

  2. two mutually exclusive functions of the DEP domain in Wnt (show WNT2 Proteins) signal transduction - binding to Frizzled to recruit Dishevelled (show DVL2 Proteins) to the receptor complex, is reported.

  3. we show that Wnt5a (show WNT5A Proteins) rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (show POLR1C Proteins) (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome.

  4. Data show that dishevelled (show DVL2 Proteins) proteins DVL1, 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).

  5. The secreted frizzled-related protein (show SFRP2 Proteins) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.

  6. Data show that receptor for activated C kinase 1 (RACK1 (show GNB2L1 Proteins)) interacts with Dishevelled (Dvl (show DVL2 Proteins)) proteins and promotes their lysosomal degradation, and this effect is enhanced by autophagy induction.

  7. TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVLl.

  8. Specific -1 frameshift variants in the penultimate exon of DVL1 cause autosomal-dominant Robinow syndrome.

  9. Results show that coexpression of IQGAP1 and Dvl (show DVL2 Proteins) in the cytoplasm and nucleus was correlated with the lymph nodal metastase and poor prognosis of non-small cell lung cancer.

  10. Data indicate Dishevelled (DVL (show DVL2 Proteins)) as a dual function adaptor to recruit negative regulators ZNRF3 (show ZNRF3 Proteins)/RNF43 (show RNF43 Proteins) to Wnt (show WNT2 Proteins) receptors to ensure proper control of pathway activity.

DVL1 Protein Profile

Protein Summary

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.

Alternative names and synonyms associated with DVL1

  • dishevelled segment polarity protein 1 (DVL1)
  • DVL protein
  • DVL1L1 protein
  • DVL1P1 protein

Protein level used designations for DVL1

DSH homolog 1 , dishevelled 1 (homologous to Drosophila dsh) , dishevelled, dsh homolog 1 , dishevelled-1 , segment polarity protein dishevelled homolog DVL-1

1855 Homo sapiens
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