Browse our P2RX4 Proteins (P2RX4)

On are 5 Purinergic Receptor P2X, Ligand-Gated Ion Channel, 4 (P2RX4) Proteins from 2 different suppliers available. Additionally we are shipping P2RX4 Antibodies (60) and many more products for this protein. A total of 73 P2RX4 products are currently listed.
AI504491, AW555605, D5Ertd444e, p2rx4, p2x4, p2x4r, wu:fi03f02
list all proteins Gene Name GeneID UniProt
P2RX4 18438  
Rat P2RX4 P2RX4 29659 P51577
P2RX4 5025 Q99571

P2RX4 Proteins (P2RX4) by Origin

More Proteins for P2RX4 Interaction Partners

Mouse (Murine) Purinergic Receptor P2X, Ligand-Gated Ion Channel, 4 (P2RX4) interaction partners

  1. These data support that P2X7 (show P2RX7 Proteins) and P2X4 receptor activation has a protective effect during severe Escherichia coli infection.

  2. This study provides a molecular mechanism for lysosomal ATP transport mediated by SLC17A9 and also suggests a regulatory mechanism of lysosomal P2X4 by SLC17A9

  3. IRF5 (show IRF5 Proteins) expression in microglia is regulated by IRF8 (show IRF8 Proteins). IRF5 (show IRF5 Proteins) directly upregulates P2rX4 expression on microglia in peripheral nerve injury, and may play a role in neuropathic pain.

  4. Specific localization of the P2X4 receptor subunit was evaluated in mouse, rat and cat retinae using fluorescence immunohistochemistry and pre-embedding immuno-electron microscopy

  5. P2X4 receptors contribute to ethanol intake and indicate that there is a complex interaction between P2X4 receptors and ethanol.

  6. Loss of P2X4 expression is associated with exaggerated renal fibrosis following unilateral ureteric obstruction.

  7. There is a protective role for endogenous cardiac myocyte P2X4R in heart failure. It is demonstrated in a physical interaction between the myocyte receptor and eNOS (show NOS3 Proteins).

  8. Our previous and current findings, combined with our preliminary evidence of increased ethanol consumption in P2X4R knockout mice, suggest that the ethanol and IVM action pocket in P2X4Rs formed by positions 42, 46, 331, and 336.

  9. The hippocampus was partially protected from status epilepticus-induced neuronal death in P2X4R-deficient mice compared with wild-type animals.

  10. Data suggest that P2X4 is expressed in majority of myenteric neurons, contributes to membrane currents activated by ATP, and plays important role in cell signaling as subunit of purinergic P2X receptor/channel.

Human Purinergic Receptor P2X, Ligand-Gated Ion Channel, 4 (P2RX4) interaction partners

  1. the intersubunit physical couplings among the DF and two lower body domains fostered by the LF domain at the open state act as an integrated structural element that is stringently required for the channel gating of P2X4 receptors.

  2. These findings provide new insights in understanding the contribution of the salt bridge between Asp (show ASIP Proteins)-85 and Arg-309 and its structurally coupled beta2,3-sheet to the function of P2X4 receptors.

  3. The results suggest a role of PrP(C (show PRNP Proteins)) in proteostasis, dysfunctions of which may be involved in the pathogenesis of neurodegenerative diseases such as TSE and Alzheimer's Disease.

  4. Fndings support role for P2X7 (show P2RX7 Proteins) and P2X4 coupled to induction of inflammatory molecules in modulating high glucose and palmitate-induced endothelial cell activation and dysfunction.

  5. These data suggest that vascular smooth muscle cells from human gastro-omental arteries express P2X1 (show P2RX1 Proteins) and P2X4 receptor subunits

  6. This study demonstrates a major physiological finding that the shear-induced effects on endothelial KLF2 (show KLF2 Proteins) axis are in part dependent on ATP release and P2X4, a previously unidentified mechanism.

  7. Using pHluorin, P2X4 was found to be expressed on the plasma membrane and within subcellular compartments in hippocampus.

  8. It appears to mediate the cells' response to extracellular ATP. Although Ca2thorn influx via P2X1 receptor is necessary for alpha-synuclein accumulation.

  9. P2X4 and calmodulin (show CALM1 Proteins) form a complex at endolysosomal membrane where P2X4 activation recruits calmodulin (show CALM1 Proteins) to promote fusion and vacuolation in a Ca(2 (show CA2 Proteins)+)-dependent fashion.

  10. the lysosome-localized P2X4 may play specific roles in membrane trafficking of acidic organelles in mammalian cells.

Xenopus laevis Purinergic Receptor P2X, Ligand-Gated Ion Channel, 4 (P2RX4) interaction partners

  1. The renal epithelial Na channel is stimulated by P2Xreceptor activation; the stimulation is dependent on increases in intracellular Ca(2 (show CA2 Proteins)) and phosphatidylinositol 3-kinase activation.

  2. A point mutation in ectodomain-transmembrane 2 of P2X4 receptor significantly reduces ethanol's inhibitory effects.

Zebrafish Purinergic Receptor P2X, Ligand-Gated Ion Channel, 4 (P2RX4) interaction partners

  1. ATP-recognition of P2X4 receptors

  2. a property that is essential for purinergic sensory signaling. Apo (show C9orf3 Proteins) and ATP-bound X-ray structures of the detergent-solubilized zebrafish P2X4 receptor provide a blueprint for receptor mechanisms

  3. crystal structure of the zebrafish P2X4 receptor in complex with ATP and a new structure of the apo (show C9orf3 Proteins) receptor

  4. Cloning and characterization of zebrafish P2X4 and P2X5 (show P2RX5 Proteins).

  5. Comparison of the acid-sensing ion channel (show ACCN2 Proteins) structure with the ATP-gated P2X(4) receptor reveals similarity in pore architecture and aqueous vestibules

P2RX4 Protein Profile

Protein Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene.

Alternative names and synonyms associated with P2RX4

  • purinergic receptor P2X, ligand-gated ion channel, 4 (P2RX4)
  • purinergic receptor P2X, ligand-gated ion channel 4 (P2rx4)
  • purinergic receptor P2X, ligand-gated ion channel, 4 (p2rx4)
  • purinergic receptor P2X, ligand-gated ion channel, 4a (p2rx4a)
  • AI504491 protein
  • AW555605 protein
  • D5Ertd444e protein
  • p2rx4 protein
  • p2x4 protein
  • p2x4r protein
  • wu:fi03f02 protein

Protein level used designations for P2RX4

purinergic receptor P2X4 , purinergic receptor P2X, ligand-gated ion channel, 4 , p2X purinoceptor 4-like , ATP receptor , P2X purinoceptor 4 , ionotropic purinergic receptor , P2X4 , ATP-gated cation channel protein , P2X receptor, subunit 4 , purinoceptor P2X4 , P2X4 purinoceptor , ATP-gated ion channel subunit P2X4 , etID14865.21 , zP2X4.1

452319 Pan troglodytes
100059626 Equus caballus
100458831 Pongo abelii
100589361 Nomascus leucogenys
18438 Mus musculus
29659 Rattus norvegicus
338036 Bos taurus
5025 Homo sapiens
448783 Canis lupus familiaris
398206 Xenopus laevis
374166 Gallus gallus
259258 Danio rerio
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