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anti-Mouse (Murine) SNCA Antibodies:
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Human Monoclonal SNCA Primary Antibody for WB - ABIN967584
Ellis, Schwartzberg, Grider, Fink, Nussbaum: alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases. in The Journal of biological chemistry 2001
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Human Monoclonal SNCA Primary Antibody for IF, IHC - ABIN968176
Jo, McLaurin, Yip, St George-Hyslop, Fraser: alpha-Synuclein membrane interactions and lipid specificity. in The Journal of biological chemistry 2000
Show all 5 Pubmed References
Human Monoclonal SNCA Primary Antibody for IF, IHC - ABIN968177
Liu, Fallon, Lashuel, Liu, Lansbury: The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. in Cell 2002
Show all 5 Pubmed References
Human Monoclonal SNCA Primary Antibody for ICC, FACS - ABIN439712
Huang, Xu, Wu, Zhou: Determining nuclear localization of alpha-synuclein in mouse brains. in Neuroscience 2011
Show all 2 Pubmed References
Human Monoclonal SNCA Primary Antibody for ELISA, WB - ABIN316106
Herva, Zibaee, Fraser, Barker, Goedert, Spillantini: Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA). in The Journal of biological chemistry 2014
Cow (Bovine) Polyclonal SNCA Primary Antibody for WB - ABIN2477391
Smith, Margolis, Li, Troncoso, Lee, Dawson, Dawson, Iwatsubo, Ross: Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Human Polyclonal SNCA Primary Antibody for ELISA, WB - ABIN4357359
Oueslati, Paleologou, Schneider, Aebischer, Lashuel: Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Human Monoclonal SNCA Primary Antibody for IHC, ELISA - ABIN1724652
Li, Lin, Xie, Hu: The early events of alpha-synuclein oligomerization revealed by photo-induced cross-linking. in Protein and peptide letters 2006
study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg) during embryogenesis
C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 (show MMRN1 Antibodies) genes, have an altered bone phenotype.
The findings of this study indicated a functional role of alpha-synuclein in early experimental autoimmune encephalomyelitis by increasing Th1 (show HAND1 Antibodies) cell-mediated immune response.
These data show that neurodegenerative processes associated with lysosomal dysfunction may be presynaptically initiated by a concomitant reduction in alpha-synuclein and CSPalpha levels at nerve terminals.
Data suggest that endocytosis is the principal mechanism by which proteopathic alpha-synuclein aggregates are internalized in primary hippocampal neurons in culture; aggregates are rapidly trafficked along endosomal/lysosomal pathway, where most of the material remains for days as proposed in neurodegenerative synucleinopathies.
LRRK2 (show LRRK2 Antibodies) negatively regulates the clearance of alphaSYN accompanied by down-regulation of the endocytosis pathway; LRRK2 (show LRRK2 Antibodies) in microglia may function as the offending molecule responsible for neurodegeneration, in terms of down-regulation of alphaSYN clearance.
sideroflexin 3 (SFXN3 (show SFXN3 Antibodies)) was found to be a mitochondrial protein (show COX6B2 Antibodies) localized to the inner mitochondrial membrane.
The ability of monomeric alpha-synuclein to enhance ATP synthase efficiency under physiological conditions may be of importance when alpha-synuclein undergoes the misfolding and aggregation
Rab7 (show RAB7A Antibodies) accumulated in GCase (show GBA Antibodies) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (show GBA Antibodies) can reverse ALR (show GFER Antibodies) impairment, we anticipate that strategies to restore GCase (show GBA Antibodies) activity in the brains of both sporadic patients with PD and those with GBA1 (show GBA Antibodies) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.
Study showed that apoptosis is an important form of cellular degeneration in lipopolysaccharide (LPS (show TLR4 Antibodies)-sensitized hypoxic-ischemic (HI) injury in the immature brain. Loss of PINK1 (show PINK1 Antibodies) can protect the immature brain against cell apoptosis induced by LPS (show TLR4 Antibodies)-sensitized HI injury. Moreover, alpha-Syn plays a neuroprotective role in LPS (show TLR4 Antibodies)-sensitized HI brain damage in PINK1 (show PINK1 Antibodies)-knockout neonatal mice
Genetic manipulation of sirtuin 2 (show SIRT2 Antibodies) levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.
Alteration of structure and aggregation of alpha-synuclein by familial Parkinson's disease associated mutations have been summarized. (Review)
Methylation of SNCA-intron1 region does not correlate with alpha-synuclein expression in Parkinson's disease samples.
Raising dopamine levels in mice expressing human mutant alpha-synuclein induced progressive nigrostriatal degeneration.
Mutant GBA (show GBA Antibodies) proteins cause increases in alpha-synuclein levels, while an inhibition of GBA (show GBA Antibodies) by alpha-synuclein has been also demonstrated in Gaucher disease patients with Parkinson disease. (Review)
RER1 (show RER1 Antibodies) is a novel and potential important mediator of elevated alphaSyn levels
Results show that both alphaS and NFL (show NEFL Antibodies) can be phosphorylated by CKII (show CSNK2A1 Antibodies), PLK2 (show PLK2 Antibodies) and PLK3 (show PLK3 Antibodies), but Ser129 in alphaS is a preferential site for PLK2 (show PLK2 Antibodies) and PLK3 (show PLK3 Antibodies), demonstrating higher phosphorylation efficiency. Comparatively, CKII (show CSNK2A1 Antibodies) preferentially phosphorylates Ser473 in NFL (show NEFL Antibodies) and this site can be phosphorylated by PLK1 (show PLK1 Antibodies), 2 and 3, but these enzymes prefer to modify other sites within NFL (show NEFL Antibodies).
two morphologically different alpha-synuclein fibrils, one helical and the other ribbon-like, are shown to form together. Surprisingly, a widely used small molecule for probing aggregation reactions, thioflavin T (ThT), was found to tune the structural heterogeneity found in the fibrils.
results indicated that the dismal prognosis of patients with HBsAg+ may be related to the high rate of PD1 (show PDCD1 Antibodies) expression. Thus, a targeted PD1 (show PDCD1 Antibodies) treatment strategy may improve the prognosis of HBsAg+ DLBCL patients
PD-1 (show PDCD1 Antibodies) in osteosarcoma patients mediated follicular helper T cells suppression.
Data show that cyclophilin 40 (CyP40) interacts with and dissolves amyloids forming proteins tau and alpha-synuclein aggregates.
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 Antibodies) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, alpha SYN
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein