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Browse our anti-SNCA (SNCA) Antibodies

Full name:
anti-Synuclein, alpha Antibodies (SNCA)
On www.antibodies-online.com are 647 Synuclein, alpha (SNCA) Antibodies from 40 different suppliers available. Additionally we are shipping SNCA Proteins (72) and SNCA Kits (65) and many more products for this protein. A total of 809 SNCA products are currently listed.
Synonyms:
alphaSYN, LOC619283, MGC64356, NACP, PARK1, PARK4, PD1, snca

All available anti-SNCA Antibodies

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Top referenced anti-SNCA Antibodies

  1. Human Monoclonal SNCA Primary Antibody for EIA, IHC (fro) - ABIN264097 : Trojanowski, Lee: \' of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders. in Annals of the New York Academy of Sciences 2001 (PubMed)
    Show all 9 references for ABIN264097

  2. Human Polyclonal SNCA Primary Antibody for EIA, IHC (p) - ABIN358988 : Kumru, Santamaria, Tolosa, Valldeoriola, Muñoz, Marti, Iranzo: Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations. in Annals of neurology 2004 (PubMed)
    Show all 5 references for ABIN358988

  3. Human Polyclonal SNCA Primary Antibody for EIA, WB - ABIN358993 : Pigullo, De Luca, Barone, Marchese, Bellone, Colosimo, Scaglione, Martinelli, Di Maria, Pizzuti, Abbruzzese, Dallapiccola, Ajmar, Mandich: Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor. in Parkinsonism & related disorders 2004 (PubMed)
    Show all 5 references for ABIN358993

  4. Human Monoclonal SNCA Primary Antibody for EIA, IHC (fro) - ABIN264470 : McLean, Kawamata, Ribich, Hyman: Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 references for ABIN264470

  5. Human Polyclonal SNCA Primary Antibody for IHC (p), WB - ABIN390364 : West, Kapatos, OFarrell, Gonzalez-de-Chavez, Chiu, Farrer, Maidment: N-myc regulates parkin expression. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN390364

  6. Human Polyclonal SNCA Primary Antibody for WB - ABIN390368 : Wang, Denison, Lai, Philips, Montoya, Kock, Schüle, Klein, Shridhar, Roberts, Smith: Parkin gene alterations in hepatocellular carcinoma. in Genes, chromosomes & cancer 2004 (PubMed)
    Show all 2 references for ABIN390368

  7. Human Monoclonal SNCA Primary Antibody for ICC, FACS - ABIN439712 : Huang, Xu, Wu, Zhou: Determining nuclear localization of alpha-synuclein in mouse brains. in Neuroscience 2011 (PubMed)
    Show all 2 references for ABIN439712

  8. Human Monoclonal SNCA Primary Antibody for ELISA, WB - ABIN316106 : Herva, Zibaee, Fraser, Barker, Goedert, Spillantini: Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA). in The Journal of biological chemistry 2014 (PubMed)

  9. Cow (Bovine) Polyclonal SNCA Primary Antibody for WB - ABIN2775366 : Wu, Kim, Fela, Baum: Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation. in Journal of molecular biology 2008 (PubMed)

  10. Human Polyclonal SNCA Primary Antibody for ELISA, WB - ABIN1531986 : Campion, Martin, Heilig, Charbonnier, Moreau, Flaman, Petit, Hannequin, Brice, Frebourg: The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease. in Genomics 1995 (PubMed)

More Antibodies against SNCA Interaction Partners

Xenopus laevis Synuclein, alpha (SNCA) interaction partners

  1. study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg (show SNCG Antibodies)) during embryogenesis

Mouse (Murine) Synuclein, alpha (SNCA) interaction partners

  1. Genetic manipulation of sirtuin 2 (show SIRT2 Antibodies) levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  2. These results indicate that fragmented amyloid-like aggregates of short alpha-syn fibrils are the key pathogenic seeds that trigger prion (show PRNP Antibodies)-like conversion.

  3. In summary, we have combined multiple data sets to identify transcripts, which are strong candidates for being phenotypic modifiers, and demonstrated SNCA is a modifier of pathology in motor neuron disease.

  4. In alpha-synuclein knock-out mice there was a decrease in neuronal glucose metabolism in cerebral cortex gray matter.

  5. alpha-synuclein may have a varying modulating effect on the growth dynamics and the fate of populations of DA neurons.

  6. In the olfactory bulb, globus pallidus and substantia nigra pars (show EPRS Antibodies) compacta, alpha-synuclein was expressed, but not in the cerebral cortex, subthalamic nucleus or thalamus.

  7. identified alpha-synuclein as a new transcriptional target of p53 (show TP53 Antibodies)

  8. High SNCA expression is associated with epilepsy.

  9. Data suggest the produced mouse lines represent a set of useful tools for studies of alpha-synuclein normal function and the role of this protein in disease pathogenesis.

  10. that loss of glucocerebrosidase (show GBA Antibodies) function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation

Human Synuclein, alpha (SNCA) interaction partners

  1. Data suggest that alpha-synuclein exhibits ferrireductase activity; the major catalytically active form is a putative membrane-associated tetramer; models suggests a mechanistic rationale for the activity and the relationship to cellular regulation of the pool of Fe(III) and Fe(II).

  2. Genetic manipulation of sirtuin 2 (show SIRT2 Antibodies) levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  3. aggregating proteins, such as amyloid-beta (Abeta (show APP Antibodies)) and alpha-synuclein (alpha-syn), proteins associated with Alzheimer's disease and synucleinopathies, respectively, share similar biophysical and biochemical properties with PrP (show C4BPA Antibodies)(Sc) that influences

  4. detected alpha synuclein in the gastrointestinal tract of patients up to 20 years prior to their Parkinson disease diagnosis.

  5. Study provides Class III evidence that p-alpha-syn skin deposits identify patients with idiopathic REM (show REM1 Antibodies) sleep behavior disorder, suggests that immunohistochemical analysis of p-alpha-syn in skin samples may be a promising safe and inexpensive marker

  6. findings suggest that, at least in Mexican Mestizos, allelic variants of the rs1801133 and rs3857059 in MTHFR (show MTHFR Antibodies) and SNCA genes account for susceptibility to Parkinson's disease and the GG genotype of the rs3857059 variant is particularly associated with PD in females of this population.

  7. This work examines the molecular mechanism by which two canonical sHsps, alphaB-crystallin (show CRYAB Antibodies) (alphaB-c) and Hsp27 (show HSPB1 Antibodies), interact with aggregation-prone alpha-syn to prevent its aggregation in vitro Both sHsps are very effective inhibitors of alpha-syn aggregation

  8. Results indicate that V63 and N65 amino acid residues of alpha-synuclein are critical residues mediating mitochondrial inactivation. These findings provide novel insight into the molecular events contributing to Parkinson disease pathogenesis.

  9. This study demonstrates that SNCA rs356182 variant has an increased risk of susceptibility to PD in Han Chinese population.

  10. These results indicate that fragmented amyloid-like aggregates of short alpha-syn fibrils are the key pathogenic seeds that trigger prion (show PRNP Antibodies)-like conversion.

Cow (Bovine) Synuclein, alpha (SNCA) interaction partners

  1. analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (show TNFAIP1 Antibodies) [ANXB12]

  2. Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.

SNCA Antigen Profile

Antigen Summary

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Alternative names and synonyms associated with SNCA

  • synuclein, alpha (snca) antibody
  • alpha-synuclein (LOC619283) antibody
  • alpha-synuclein (LOC100359228) antibody
  • synuclein, alpha (Snca) antibody
  • synuclein, alpha (non A4 component of amyloid precursor) (SNCA) antibody
  • synuclein, alpha (non A4 component of amyloid precursor) (Snca) antibody
  • alphaSYN antibody
  • LOC619283 antibody
  • MGC64356 antibody
  • NACP antibody
  • PARK1 antibody
  • PARK4 antibody
  • PD1 antibody
  • snca antibody

Protein level used designations for anti-Synuclein, alpha (SNCA) Antibodies

synuclein, alpha , alpha-synuclein , alpha SYN , non-A beta component of AD amyloid , non-A4 component of amyloid , non A-beta component of AD amyloid , synuclein alpha-140 , alpha synuclein

GENE ID SPECIES
380315 Xenopus laevis
619283 Takifugu rubripes
100359228 Oryctolagus cuniculus
20617 Mus musculus
6622 Homo sapiens
29219 Rattus norvegicus
641350 Sus scrofa
282857 Bos taurus
395393 Gallus gallus
100294604 Ovis aries
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