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SMURF2 Antibodies

(SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
SMURF2 antibody  (AA 601-700) SMURF2 antibody  (AA 601-700) SMURF2 antibody (AA 601-700) (ABIN753178)

SMURF2 Reactivity: Human, Mouse, Rat ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p), WB Host: Rabbit Polyclonal unconjugated

SMURF2 antibody  (N-Term) SMURF2 antibody  (N-Term) SMURF2 antibody (N-Term) (ABIN6657084)

SMURF2 Reactivity: Human ELISA, FM, IHC, WB Host: Rabbit Polyclonal unconjugated

SMURF2 antibody  (AA 1-748) SMURF2 antibody  (AA 1-748) SMURF2 antibody (AA 1-748) (ABIN7151226)

SMURF2 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated

SMURF2 Antibodies by Reactivity

Find SMURF2 Antibodies for a variety of species such as anti-Human SMURF2, anti-Mouse SMURF2, anti-Rat SMURF2. The species listed below are among those available. Click on a link to go to the corresponding products.

SMURF2 Antibodies by Application

Find SMURF2 Antibodies validated for a specific application such as WB, ELISA, IHC, IF. Some of the available applications are listed below. Click on a link to go to the corresponding products.

SMURF2 Antibodies by Host

Find SMURF2 Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

SMURF2 Antibodies by Binding Specificity

Find SMURF2 Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

SMURF2 Antibodies by Clonality

Find available monoclonal or polyclonal SMURF2 Antibodies. Click on a link to go to the corresponding products.

SMURF2 Antibodies by Clone

Find SMURF2 Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

SMURF2 Antibodies by Conjugate

Find SMURF2 Antibodies with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular SMURF2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF, IHC, WB
Validations
  • (2)
Cat. No. ABIN6265196
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application EIA, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN357471
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human, Mouse
Application EIA, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN357472
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN3044498
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Rat
Application IF, IHC (p), WB
Validations
  • (1)
Cat. No. ABIN388831
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (1)
Cat. No. ABIN2503142
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7151227
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN7151228
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7151229
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IF, IHC (p), WB
Validations
Cat. No. ABIN6991997
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IF, IHC (p), WB
Validations
Cat. No. ABIN5690259
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC (fro), IHC (p), WB
Validations
Cat. No. ABIN753180
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
Cat. No. ABIN6243825
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application FACS, IF (cc), IF (p)
Validations
Cat. No. ABIN753181
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application FACS, IF (cc), IF (p)
Validations
Cat. No. ABIN753182
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our SMURF2 Antibodies

Li, Wang, Xie, Wang, Cen, Li, Liu, Tang, Ye, Zheng, Su, Ma, Wu, Wu, Shen: "TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2." in: Cell death and differentiation, (2019) (PubMed).

Tovar-Vidales, Fitzgerald, Clark: "Human trabecular meshwork cells express BMP antagonist mRNAs and proteins." in: Experimental eye research, Vol. 147, pp. 156-60, (2016) (PubMed).

Huang, Yang, Nan, Gao, Feng, Gou, Chen, Zhang, Yan, Peng, Xu: "The proteasome inhibitor, MG132, attenuates diabetic nephropathy by inhibiting SnoN degradation in vivo and in vitro." in: BioMed research international, Vol. 2014, pp. 684765, (2015) (PubMed).

He, Yang, Isales, Shi: "Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-? inhibition of mesenchymal stem cell osteogenic differentiation." in: PLoS ONE, Vol. 7, Issue 3, pp. e31717, (2012) (PubMed).

Schwamborn, Khazaei, Püschel: "The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity." in: The Journal of biological chemistry, Vol. 282, Issue 48, pp. 35259-68, (2007) (PubMed).

Schwamborn, Müller, Becker, Püschel: "Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity." in: The EMBO journal, Vol. 26, Issue 5, pp. 1410-22, (2007) (PubMed).

Zhang, Chang, Gehling, Hemmati-Brivanlou, Derynck: "Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 3, pp. 974-9, (2001) (PubMed).

Kavsak, Rasmussen, Causing, Bonni, Zhu, Thomsen, Wrana: "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation." in: Molecular cell, Vol. 6, Issue 6, pp. 1365-75, (2001) (PubMed).

Lin, Liang, Feng: "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling." in: The Journal of biological chemistry, Vol. 275, Issue 47, pp. 36818-22, (2001) (PubMed).

Aliases for SMURF2 Antibodies

SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) Antibodies
SMAD specific E3 ubiquitin protein ligase 2 (smurf2) Antibodies
SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) Antibodies
SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S) Antibodies
2810411E22Rik Antibodies
AI558114 Antibodies
AI649275 Antibodies
RGD1310067 Antibodies
SMURF2 Antibodies
wu:fb82a11 Antibodies
wu:fc41c02 Antibodies
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