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Human beta-2 Microglobulin Protein expressed in Insect Cells - ABIN1305114
Shields, Moffat, Ribaudo: Functional comparison of bovine, murine, and human beta2-microglobulin: interactions with murine MHC I molecules. in Molecular immunology 1999
Show all 2 Pubmed References
Human beta-2 Microglobulin Protein expressed in Escherichia coli (E. coli) - ABIN2128134
Neethling, Ramakrishna, Keler, Buchli, Woodburn, Weidanz: Assessing vaccine potency using TCRmimic antibodies. in Vaccine 2008
The results show that, although other factors influence the fibril growth kinetics, a striking difference in the solubility of the proteins is a key determinant of the different amyloidogenicity of human B2M and mouse B2M.
Use of shRNA against beta-2-microglobulin offers a simple and effective approach to minimize immunogenicity of the main cellular components of cardiac tissue constructs in non-syngeneic recipients.
systemic B2M accumulation in aging blood promotes age-related cognitive dysfunction and impairs neurogenesis
Because all forms of H-2K(b) are internalized but little beta2m-receptive heavy chain is present at the cell surface, it is likely that beta2m dissociation and recognition of the heavy chain for lysosomal degradation take place in an endocytic compartment.
We report a novel dichotomous role of beta2m and CD1d, whereby these molecules differently regulate autoimmunity against phospholipid versus non-phospholipid autoantigens.
The goal of the present work was to study peculiarities in functioning of proteasomes and associated signaling pathways along with evaluation of NeuN (show RBFOX3 Proteins) and gFAP (show GFAP Proteins) expression in different sections of the brain in mice.
MHC I and b2m genes are both expressed in in human as well as mice during the developmental stages of cerebellar cortex
Knocking out beta 2 microglobulin abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits.
This study demonistrated that Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis
Data show that tapasin (show TAPBP Proteins) expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms.
Serum B2M level was positively associated with Gensini score system, SYNTAX score system and the number of diseased coronary vessels.
Data suggest that T-cell receptor (TCR) alpha-constant domain (C- and F-strands) directly interacts with unbound MHC light chain, beta2-microglobulin (beta2M); these interactions do not appear to be involved in T-cell cytotoxicity, suggesting an alternate role for beta2M binding to TCR; TCR beta-chain does not appear to interact directly with beta2M.
High B2M levels were associated with an increased risk of ischemic stroke in this study of middle-aged women
Letter: serum levels of anti-carbonic anhydrase autoantibodies and beta macroglobulin correlate with ClinESSDAI score in patients with Sjogren's syndrome.
Beta2M mRNA expression in cells of the urinary sediment is higher in T1D patients with diabetic kidney disease and in patients with focal segmental glomerulosclerosis in comparison to healthy subjects, maybe reflecting a tubulointerstitial injury promoted by albumin (show ALB Proteins).
Serum levels of beta trace protein and beta 2 microglobulin can be used to predict residual kidney function in hemodialysis patients.
The chaperone crystallin, which is a mild modulator of the lag (show STMN1 Proteins) phase of the variant fibrillogenesis, potently inhibits fibril elongation of the wild-type even once it is absorbed on D76N beta2-microglobulin fibrils.
B2M is a potential tissue biomarker and therapeutic target of borderline and malignant ovarian tumours and the dysregulation of B2M in these tumours may be mediated by the TGF-beta (show TGFB1 Proteins) signaling pathway.
BTP and B2M levels are less affected than serum by amputation, and should be considered for future study of GFR (show RAPGEF5 Proteins) estimation
Overexpression of B2M are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma.
B2M contains alpha-helix, beta-sheet, turn, and random coil.
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
beta chain of MHC class I molecules
, beta-2-microglobulin C-terminal fragment (55 AA)
, beta 2-microglobulin
, beta-2 microglobulin
, beta 2 microglobulin
, beta-2-microglobulin-like protein
, beta2 microglobulin
, beta 2-m
, beta 2 microglobulin (54 AA)