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Egr2 (show EGR2 ELISA Kits)-driven cell surface proteins LAG-3 (show LAG3 ELISA Kits) and 4-1BB can identify dysfunctional tumor antigen-specific CD8 (show CD8A ELISA Kits)(+) TIL (show TLR1 ELISA Kits).
Findings indicate that CD137 antigen is a useful marker that can be used for identifying Mycobacterium tuberculosis (Mtb (show NCAPG2 ELISA Kits))-reactive CD4 (show CD4 ELISA Kits)(+) T cells (Mtb (show NCAPG2 ELISA Kits)-reactive CD4 (show CD4 ELISA Kits)(+) T cells) by flow cytometry.
Anti-4-1BB single chain variable fragments enhanced surface CD69 (show CD69 ELISA Kits) expression and interleukin-2 (show IL2 ELISA Kits) production in stimulated CCRF-CEM cells which confirmed the agonistic effect of the selected single chain variable fragments. The data from this study have provided a rationale for further experiments involving the biological functions of anti-4-1BB single chain variable fragments in future studies.
Studies suggest that adoptive T cell therapy and CD137 antigen offer much opportunity to raise the efficacy of current cancer immunotherapies.
Triple costimulation via CD80 (show CD80 ELISA Kits), 4-1BB, and CD83 (show CD83 ELISA Kits) ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2 (show IL2 ELISA Kits).
These studies provide the first direct evidence that ligation of tumour necrosis factor (show TNF ELISA Kits) superfamily members and their cognate receptors is important for the control of viral lytic replication.
Our findings provide a novel, TNFRSF9-positive, reactive astrocytic phenotype in human gliomas
Human genetic evidence for involvement of CD137 in atherosclerosis
As a result of becoming activated, transferred human T lymphocytes express the inducible surface antigens hPD-1 (show PDCD1 ELISA Kits) and hCD137 on their plasma membrane.
Our results provide biological explanations for the antitumor effects of CD19 (show CD19 ELISA Kits) CARs and for the observations that CD19 (show CD19 ELISA Kits) CAR T cells incorporating the 4-1BB costimulatory domain are more persistent than those incorporating CD28 (show CD28 ELISA Kits) in clinical trials.
This study discovers the 4-1BB pathway signaling enhances inflammatory response and promotes pulmonary fibrosis induced by crystalline silica.
Constitutive interaction between 4-1BB and 4-1BBL (show TNFSF9 ELISA Kits) on murine LPS (show TLR4 ELISA Kits)-activated bone marrow dendritic cells masks detection of 4-1BBL (show TNFSF9 ELISA Kits) by TKS (show PTK6 ELISA Kits)-1 but not 19H3 antibody.
results indicate that one important diabetogenic function of CD137 is to promote the expansion and accumulation of beta cell-autoreactive CD8 (show CD8A ELISA Kits) T cells, and in the absence of CD137 or its interaction with CD137 ligand, type 1 diabetes progression is suppressed
High CD137 expression is associated with neoplasms.
Ly6C, 4-1BB, and KLRG1 (show KLRG1 ELISA Kits) have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease
CD137 Regulates NFATc1 (show NFATC1 ELISA Kits) Expression in Mouse VSMCs through TRAF6 (show TRAF6 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) p65 (show NFkBP65 ELISA Kits) Signaling Pathway.
4-1BB triggering preferentially enhances the expansion of CD8 (show CD8A ELISA Kits)+ T cells through the amplification of autocrine IL-2 (show IL2 ELISA Kits)/IL-2R signaling loop.
c-IAP (show ALPI ELISA Kits) ubiquitin protein ligase (show UBE2K ELISA Kits) activity is required for 4-1BB signaling and CD8 (show CD8A ELISA Kits)(+) memory T-cell survival.
we conclude that in vivo 4-1BB signaling of myeloid cells negatively regulates peripheral T cell responses
activation of CD137 signaling decreases the stability of advanced atherosclerotic plaques via its combined effects on Teff cells, vascular smooth muscle cells, and macrophages
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
tumor necrosis factor receptor superfamily, member 9
, tumor necrosis factor receptor superfamily member 9
, 4-1BB ligand receptor
, CD137 antigen
, T cell antigen ILA
, T-cell antigen 4-1BB homolog
, T-cell antigen ILA
, homolog of mouse 4-1BB
, induced by lymphocyte activation (ILA)
, interleukin-activated receptor, homolog of mouse Ly63
, receptor protein 4-1BB
, T-cell antigen 4-1BB
, secreted CD137 antigen