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Human CREB1 Protein expressed in Wheat germ - ABIN1350285
Yin, Li, Yang, Gao, Sun, Li: Detection of CREB phosphorylation via Zr (IV) ion mediated signal amplification. in Biosensors & bioelectronics 2014
CREB is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC.
The sequence of the CREB gene contains a 88 bp 5' UTR, a 783 bp open reading frame encoding 261 amino acids and a 348 bp 3' UTR.
Data indicate increasing expression for CREB, ATF1 (show AFT1 Proteins), and ATF3 (show ATF3 Proteins) during gastrulation.
Inhibition of CaN attenuated the hTau-induced CREB dephosphorylation with improved synapse and memory functions.
Via blocking the hypoxia-mediated reduction in CREB phosphorylation.
The study adds evidence that CREB, a tumor oncogene (show RAB1A Proteins), promotes renal cell carcinoma (show MOK Proteins) proliferation. It probably achieves this by increasing SKA2 (show FAM33A Proteins) expression
cigarette smoke extracts activate the PKA, CREB, and IL-13Ralpha2 axis in lung endothelial cells.
This study showed that the induction level of IL-32 (show IL32 Proteins) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (show IRF6 Proteins)-induced IL-32 (show IL32 Proteins) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (show TLR4 Proteins)/JNK (show MAPK8 Proteins)/AKT (show AKT1 Proteins)/CREB signaling pathway.
Studies indicate that the small molecule ICG-001 selectively blocks the cAMP response element-binding (CREB) protein (CBP (show CREBBP Proteins))/beta-catenin (show CTNNB1 Proteins) or gamma-catenin (show JUP Proteins) interaction.
Study indicates that BPA (show DST Proteins) increases phosphorylated CREB in MCF-7 Cells as well as it binding to SOX2 (show SOX2 Proteins) enhancer.
study concludes that miR-132 regulated SIRT1/CREB/ABCG2 signaling pathway contributing to the cisplatin resistance and might serve as a novel therapeutic target against gastric cancer
Leptin (show LEP Proteins) also significantly increased cAMP levels, cAMP response element (CRE) activation, and CREB phosphorylation.
these data show the existence of functional CREB and C/EBP (show CEBPA Proteins) binding sites in the human RIC8B gene promoter, a particular distribution of these sites and demonstrate a relevant role of CREB in stimulating transcriptional activity of this gene.
LH induces MAPK3 (show MAPK3 Proteins)/1 and Akt (show AKT1 Proteins) activation, both of which are required for the CREB-promoted expression of EGF (show EGF Proteins)-like factors in granulosa cells.
However, the mechanism that induces release of IL-6 (show IL6 Proteins) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (show IL6 Proteins) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway.
NFIL3 (show NFIL3 Proteins) functions as an important regulator of glucose homeostasis in the liver by limiting CREB-mediated hepatic gluconeogenesis
EGCG significantly ameliorated insulin (show INS Proteins) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1 (show IRS1 Proteins))/AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins)/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF (show BDNF Proteins)) signaling pathways.
Ca(2 (show CA2 Proteins)+) signaling pathway increases Nr4a1 (show NR4A1 Proteins) expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (show MEF2C Proteins), AP1 (show JUN Proteins), and CREB transcription factors thus demonstrating an important interplay between the Ca(2 (show CA2 Proteins)+) and cAMP pathways in regulating Nr4a1 (show NR4A1 Proteins) expression.
PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway.
study revealed the involvement of CREB in B-1a cells, which was upregulated to increase the production of IL-10 (show IL10 Proteins) for attenuating inflammation and organ injury, and finally improving survival during sepsis
In conclusion, glucocorticoid couples mGR (show GRHL1 Proteins) with Galphas (show GNAS Proteins) and triggers cAMP-PKA-CREB axis dependent on the lipid raft to stimulate BACE1 (show BACE Proteins) upregulation and Abeta (show APP Proteins) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.
CREB was found to bind to GSK3beta promoter and essential for cAMP-mediated regulation of GSK3beta.
The NR2B (show GRIN2B Proteins)-CREB-miR212/132-CRTC1 (show CRTC1 Proteins)-CREB signal network plays an important role in the regulation of pain.
The expression of porcine Prdx6 (show PRDX6 Proteins) gene is up-regulated by C/EBPbeta (show CEBPB Proteins) and CREB.
Results suggest that cerebral hypoxia results in differential regulation of CREB protein-mediated expression of proapoptotic and antiapoptotic proteins in the cerebral cortex of newborn piglets.
Data indicate that Ser738/742-to-glutamate (show GRIN2A Proteins) protein kinase D (show PRKD1 Proteins) mutant increased AngII-induced CREB protein and activating transcription factor 2 (show ATF2 Proteins) phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein (show STAR Proteins) promoter.
SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia.
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 (show LYPLA1 Proteins)
the p38-MAPK (show MAPK14 Proteins)/CREB pathway plays a critical role in TNFalpha (show TNF Proteins)-induced VCAM-1 (show VCAM1 Proteins) expression
We found several conserved cis elements in the frog CRF genes including a cAMP response element (CRE), activator protein 1 binding sites, and glucocorticoid response elements
p38 MAPK (show MAPK14 Proteins) and CREB function along the dorsal-ventral axis in mesoderm patterning. The phosphorylated form of CREB (S133) is distributed in a gradient along the dorsal-ventral mesoderm axis and the p38 MAPK (show MAPK14 Proteins) pathway mediates the phosphorylation of CREB.
modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
cAMP responsive element binding protein 1
, cAMP responsive element binding protein
, cyclic AMP-responsive element-binding protein 1
, active transcription factor CREB
, cAMP-response element-binding protein-1
, cAMP-responsive element-binding protein 1
, transactivator protein
, Y protein
, cAMP response element binding protein 1
, cAMP response element-binding protein
, cyclic AMP-responsive element binding protein, delta
, cyclic AMP-responsive DNA-binding protein