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CREB1 Protein (GST tag)

CREB1 Origin: Rat Host: Escherichia coli (E. coli) Recombinant >70% WB
Rockland
Catalog No. ABIN6699573
Supplier Product No.: 012-001-r73s
  • Target See all CREB1 Proteins
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Protein Type
    Recombinant
    Origin
    • 5
    • 1
    • 1
    Rat
    Source
    • 4
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This CREB1 protein is labelled with GST tag.
    Application
    Western Blotting (WB)
    Supplier Product No.
    012-001-r73s
    Supplier
    Rockland
    Purpose
    CREB1 recombinant protein-GST fusion protein
    Purification
    Recombinant rat CREB1 (1-280) was expressed in E.coli cells using an N-Terminal Glutathione-S-Transferase fusion protein. The purity was determined to be >70% by densitometry.
    Purity
    >70%
    Top Product
    Discover our top product CREB1 Protein
  • Application Notes

    Western_Blot_Dilution: User Optimized

    Other: Kinase Assay-User Optimized

    Application_Note: CREB1 Protein is suitable for use in Western Blot and Kinase Assay. Expect a band approximately ~ 59 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.2 μg/μL
    Buffer
    CREB1 Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Alternative Name
    Creb1 (CREB1 Products)
    Background

    Synonyms: cAMP Responsive Element Binding Protein 1, creb, Cyclic AMP-responsive element-binding protein 1, CREB-1, cAMP-responsive element-binding protein 1

    Background: CREB1 is a member of the cAMP responsive element binding protein family of transcription factors that are critical mediators of gene expression in response to extracellular signals and are essential regulators of adaptive behavior and long-term memory formation (1). Activation of CREB1 by protein kinase A-mediated phosphorylation has been implicated in the survival of mammalian cells. Mice lacking CREB in the central nervous system during development show extensive apoptosis of postmitotic neurons (2). CREB binds as homo- and heterodimers to promoters containing CRE and activator protein 1 (AP-1) sites to alter target-gene expression). CREB1 Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, and PKA/PKC Pathway research.

    NCBI Accession
    NM_031017
    Pathways
    TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
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