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Browse our IRF4 Proteins (IRF4)

Full name:
Interferon Regulatory Factor 4 Proteins (IRF4)
On are 11 Interferon Regulatory Factor 4 (IRF4) Proteins from 7 different suppliers available. Additionally we are shipping IRF4 Antibodies (132) and IRF4 Kits (8) and many more products for this protein. A total of 162 IRF4 products are currently listed.
AI385587, IRF-4, irf4, LSIRF, MUM1, NF-EM5, si:ch73-170d1.2, Spip
list all proteins Gene Name GeneID UniProt
IRF4 3662 Q15306
IRF4 16364 Q64287
Rat IRF4 IRF4 291100  

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IRF4 Proteins (IRF4) by Origin

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More Proteins for IRF4 Interaction Partners

Human Interferon Regulatory Factor 4 (IRF4) interaction partners

  1. This study identified a novel shared locus, IRF4, for the risk of systemic sclerosis and rheumatoid arthritis, and highlighted the usefulness of a cross-disease GWAS meta-analysis strategy in the identification of common risk loci

  2. High IRF4 expression is associated with lymphoma in Waldeyer ring.

  3. These findings suggest for the first time that IRF4 rs12203592 plays a role in the modulation of melanoma outcome and confirms its contribution to the localization of the primary tumour.

  4. results definitively show that LMP1 (show PDLIM7 Proteins) promotes IRF4 tyrosine phosphorylation and markedly stimulates its transcriptional activity through recruiting Src (show SRC Proteins) via P85

  5. IRF4 and CRBN (show CRBN Proteins) polymorphisms affect risk and response to treatment in multiple myeloma

  6. This meta-analysis indicates that the IL-6 (show IL6 Proteins) gene -174G/C and interferon regulatory factor 4 polymorphisms may be associated with an increased skin cancer risk.

  7. Study demonstrate that IRF4 acts as an inhibitor of epithelial cell proliferation and mediates the expression of TIPE2 (show TNFAIP8L2 Proteins), a negative regulator of TLR signaling, to control cell growth.

  8. The anti-PEL effects of IMiDs involved cereblon-dependent suppression of IRF4 and rapid degradation of IKZF1

  9. IRF4 single nucleotide polymorphism is predictive factor of melanoma subtypes.

  10. Role of IRF4 rs12203592 in pathway-specific risk for melanoma development. Hypothesize that IRF4 rs12203592 could underlie in part the bimodal age distribution reported for melanoma and linked to the divergent pathways

Mouse (Murine) Interferon Regulatory Factor 4 (IRF4) interaction partners

  1. this study shows that PU.1 functions as a positive regulator of CD11c (show ITGAX Proteins) gene expression by directly binding to the Itgax (show ITGAX Proteins) promoter and through transactivation of the Irf4 gene

  2. this study shows that the affinity of different enhancers for the BATF-IRF4 complex might underlie divergent signaling outcomes in response to various strengths of TCR signaling

  3. this study shows that baicalin upregulates IRF4 protein expression and alleviates colitis by modulating macrophage polarization to the M2 phenotype

  4. Group 2 innate lymphoid cells utilize the IRF4-IL-9 (show IL9 Proteins) module to coordinate epithelial cell maintenance of lung homeostasis.

  5. data reveal that CCR7 (show CCR7 Proteins) plays multifaceted roles in regulating collecting vessel permeability and fibrosis, with one of the key players being IRF4-dependent DCs.

  6. IRF4 was essential for the survival of plasma cells.

  7. a critical role for IRF4 in regulating protective anti-viral CD8 (show CD8A Proteins)+ T cell responses by ensuring a balanced ratio of T-bet to Eomes (show EOMES Proteins)

  8. variation in IRF4 or IRF8 (show IRF8 Proteins) levels resulting from genetic polymorphisms or environmental cues will govern tissue dendritic cells numbers and regulate the magnitude of their functional responses.

  9. DC dysfunction in lupus-prone mice relies on both IRF4-dependent and IRF4-independent pathways

  10. APN (show ANPEP Proteins) can help to reduce periodontitis-related bone loss, modulate JMJD3 and IRF4 expression, and macrophage infiltration.

Zebrafish Interferon Regulatory Factor 4 (IRF4) interaction partners

  1. IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.

IRF4 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6\;14)(p25\;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with IRF4

  • interferon regulatory factor 4 (IRF4)
  • Interferon regulatory factor 4 (irf4)
  • interferon regulatory factor 4 (LOC100223845)
  • interferon regulatory factor 4 (Irf4)
  • interferon regulatory factor 4a (irf4a)
  • melanoma associated antigen (mutated) 1 (MUM1)
  • AI385587 protein
  • IRF-4 protein
  • irf4 protein
  • LSIRF protein
  • MUM1 protein
  • NF-EM5 protein
  • si:ch73-170d1.2 protein
  • Spip protein

Protein level used designations for IRF4

interferon regulatory factor 4 , Interferon regulatory factor 4 , lymphocyte-specific interferon regulatory factor , multiple myeloma oncogene 1 , NF-EM5 , PU.1 interaction partner , Sfpi1/PU.1 interaction partner , transcriptional activator PIP , irf4 , MUM-1 , PWWP domain-containing protein MUM1 , mutated melanoma-associated antigen 1

462386 Pan troglodytes
722883 Macaca mulatta
100194953 Salmo salar
100223845 Taeniopygia guttata
100590106 Nomascus leucogenys
3662 Homo sapiens
374179 Gallus gallus
100144625 Sus scrofa
16364 Mus musculus
291100 Rattus norvegicus
100002070 Danio rerio
612320 Canis lupus familiaris
513471 Bos taurus
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