Browse our IRF4 Proteins (IRF4)

Full name:
Interferon Regulatory Factor 4 Proteins (IRF4)
On are 11 Interferon Regulatory Factor 4 (IRF4) Proteins from 7 different suppliers available. Additionally we are shipping IRF4 Antibodies (142) and IRF4 Kits (8) and many more products for this protein. A total of 172 IRF4 products are currently listed.
AI385587, IRF-4, irf4, LSIRF, MUM1, NF-EM5, si:ch73-170d1.2, Spip
list all proteins Gene Name GeneID UniProt
IRF4 3662 Q15306
IRF4 16364 Q64287
Rat IRF4 IRF4 291100  

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IRF4 Proteins (IRF4) by Origin

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More Proteins for IRF4 Interaction Partners

Human Interferon Regulatory Factor 4 (IRF4) interaction partners

  1. PU.1-induced apoptosis in myeloma cells is associated with IRF4 downregulation and subsequent IRF7 (show IRF7 Proteins) upregulation.

  2. GM-CSF (show CSF2 Proteins) can mediate inflammation and pain by regulating IRF4-induced CCL17 (show CCL17 Proteins) production

  3. expression of CARMA1 (show CARD11 Proteins) mRNA is likely associated with the expression of MUM1 and shows male predominance in diffuse large B cell lymphoma.

  4. Data show that BCL-6 (show BCL6 Proteins) (64%) and MUM1 (45%) were expressed in patients with primary mediastinal large B-cell lymphoma.

  5. The study demonstrated differential MUM-1 expression between PEComas and other true melanocytic tumors

  6. Mum-1 was positive in all but one case (96.7%) of systemic anaplastic large-cell lymphoma by tissue microarray immunohistochem analysis.

  7. These results show that MUM1 is a strong and robust predictive immunohistochemical marker in patients with follicular lymphoma

  8. MUM1 expression is reliable in the prognosis of diffuse large B-cell lymphoma.

  9. MUM-1 could be a useful marker for the differential diagnosis of angioimmunoblastic T cell lymphoma (AITL) with Hodgkin/Reed-Sternberg like cells and classical Hodgkins lymphoma.

  10. identify PDL1 (show CD274 Proteins) and MUM1 as prognostic biomarkers for high-risk disease in primary mediastinal large B-cell lymphoma

Mouse (Murine) Interferon Regulatory Factor 4 (IRF4) interaction partners

  1. GM-CSF (show CSF2 Proteins) can mediate inflammation and pain by regulating IRF4-induced CCL17 (show CCL17 Proteins) production

  2. MTORC2 (show CRTC2 Proteins) operated in parallel with the IL-4Ralpha-Stat6 (show STAT6 Proteins) pathway.

  3. IRF4 mRNA and protein expression was remarkably suppressed during the development of myeloid-derived suppressor cells in the tumor microenvironment. IRF4 expression in MDSCs can modulate their activity to inhibit T cell proliferation through IL-10 (show IL10 Proteins) production and ROS (show ROS1 Proteins) generation, and myeloid-specific deletion of IRF4 leads to the increase of MDSC differentiation. IRF4 reduction induced by tumors can increase MDSC numbers.

  4. propose that Irf4 is imperative for thymic Treg homeostasis because it regulates thymic epithelial cell-specific expression of several chemokines and costimulatory molecules indicated in thymocyte development and Treg induction

  5. MHC II(+) resident peritoneal and pleural macrophages are continuously replenished by blood monocytes recruited to the peritoneal and pleural cavities constitutively, starting after birth, where they require IRF4 and signals likely derived from the microbiome to fully differentiate.

  6. this study shows that PU.1 functions as a positive regulator of CD11c (show ITGAX Proteins) gene expression by directly binding to the Itgax (show ITGAX Proteins) promoter and through transactivation of the Irf4 gene

  7. this study shows that the affinity of different enhancers for the BATF-IRF4 complex might underlie divergent signaling outcomes in response to various strengths of TCR signaling

  8. this study shows that baicalin upregulates IRF4 protein expression and alleviates colitis by modulating macrophage polarization to the M2 phenotype

  9. Group 2 innate lymphoid cells utilize the IRF4-IL-9 (show IL9 Proteins) module to coordinate epithelial cell maintenance of lung homeostasis.

  10. data reveal that CCR7 (show CCR7 Proteins) plays multifaceted roles in regulating collecting vessel permeability and fibrosis, with one of the key players being IRF4-dependent DCs.

Zebrafish Interferon Regulatory Factor 4 (IRF4) interaction partners

  1. IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.

IRF4 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6\;14)(p25\;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with IRF4

  • interferon regulatory factor 4 (IRF4)
  • Interferon regulatory factor 4 (irf4)
  • interferon regulatory factor 4 (LOC100223845)
  • interferon regulatory factor 4 (Irf4)
  • interferon regulatory factor 4a (irf4a)
  • melanoma associated antigen (mutated) 1 (MUM1)
  • AI385587 protein
  • IRF-4 protein
  • irf4 protein
  • LSIRF protein
  • MUM1 protein
  • NF-EM5 protein
  • si:ch73-170d1.2 protein
  • Spip protein

Protein level used designations for IRF4

interferon regulatory factor 4 , Interferon regulatory factor 4 , lymphocyte-specific interferon regulatory factor , multiple myeloma oncogene 1 , NF-EM5 , PU.1 interaction partner , Sfpi1/PU.1 interaction partner , transcriptional activator PIP , irf4 , MUM-1 , PWWP domain-containing protein MUM1 , mutated melanoma-associated antigen 1

462386 Pan troglodytes
722883 Macaca mulatta
100194953 Salmo salar
100223845 Taeniopygia guttata
100590106 Nomascus leucogenys
3662 Homo sapiens
374179 Gallus gallus
100144625 Sus scrofa
16364 Mus musculus
291100 Rattus norvegicus
100002070 Danio rerio
612320 Canis lupus familiaris
513471 Bos taurus
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