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Browse our IRF4 Proteins (IRF4)

Full name:
Interferon Regulatory Factor 4 Proteins (IRF4)
On are 12 Interferon Regulatory Factor 4 (IRF4) Proteins from 8 different suppliers available. Additionally we are shipping IRF4 Antibodies (137) and IRF4 Kits (6) and many more products for this protein. A total of 166 IRF4 products are currently listed.
AI385587, IRF-4, irf4, LSIRF, MUM1, NF-EM5, si:ch73-170d1.2, Spip
list all proteins Gene Name GeneID UniProt
IRF4 3662 Q15306
IRF4 16364 Q64287
Rat IRF4 IRF4 291100  

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IRF4 Proteins (IRF4) by Origin

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Human Interferon Regulatory Factor 4 (IRF4) interaction partners

  1. The anti-PEL effects of IMiDs involved cereblon-dependent suppression of IRF4 and rapid degradation of IKZF1

  2. IRF4 single nucleotide polymorphism is predictive factor of melanoma subtypes.

  3. Role of IRF4 rs12203592 in pathway-specific risk for melanoma development. Hypothesize that IRF4 rs12203592 could underlie in part the bimodal age distribution reported for melanoma and linked to the divergent pathways

  4. These results indicate that the KDM3A (show KDM3A Proteins)-KLF2 (show KLF2 Proteins)-IRF4 pathway plays an essential role in multiple myeloma cell survival and homing to the bone marrow, and therefore represents a therapeutic target.

  5. FOXO1 (show FOXO1 Proteins) and PR are required for the regulation of IRF4, a novel transcriptional regulator of decidualization in human endometrial stromal cells.

  6. inhibition of IRF4 translated into downregulation of c-Myc (show MYC Proteins), caspase-10 (show CASP10 Proteins) and cFlip (show CFLAR Proteins), relevant IRF4-downstream effectors

  7. Overall, our data strongly suggest that IRF4, MC1R (show MSHR Proteins) and TYR (show TYR Proteins) genes likely have pleiotropic effects, a combination of pigmentation and oncogenic functions, resulting in an increased risk of actinic keratosis.

  8. collagen I induces TNF- alpha (show TNF Proteins) production, which is crucial for the activation and function of DCs, through down-regulation of IRF4, and implicates the importance in development of anti- TNF-alpha (show TNF Proteins) therapeutics for several inflammatory diseases.

  9. Allele-specific transcriptional regulation of IRF4 in melanocytes is mediated by chromatin looping of the intronic rs12203592 enhancer to the IRF4 promoter

  10. IRF4 is deregulated in B cells from common variable immunodeficiency patients, contributing to the observed aberrant expression of activation-induced deaminase (show AICDA Proteins) in these patients.

Mouse (Murine) Interferon Regulatory Factor 4 (IRF4) interaction partners

  1. data reveal that CCR7 (show CCR7 Proteins) plays multifaceted roles in regulating collecting vessel permeability and fibrosis, with one of the key players being IRF4-dependent DCs.

  2. IRF4 was essential for the survival of plasma cells.

  3. a critical role for IRF4 in regulating protective anti-viral CD8 (show CD8A Proteins)+ T cell responses by ensuring a balanced ratio of T-bet to Eomes (show EOMES Proteins)

  4. variation in IRF4 or IRF8 (show IRF8 Proteins) levels resulting from genetic polymorphisms or environmental cues will govern tissue dendritic cells numbers and regulate the magnitude of their functional responses.

  5. DC dysfunction in lupus-prone mice relies on both IRF4-dependent and IRF4-independent pathways

  6. APN (show ANPEP Proteins) can help to reduce periodontitis-related bone loss, modulate JMJD3 and IRF4 expression, and macrophage infiltration.

  7. Data indicate that interferon (show IFNA Proteins) regulatory factors IRF4 and IRF8 (show IRF8 Proteins) control distinct activated B cell states.

  8. this study determined the small angle x-ray scattering solution structure of full-length IRF4, which, together with circular dichroism studies, suggests that the linker region is not extended but folds into a domain structure

  9. data support a novel and critical role for Nr4a1 (show NR4A1 Proteins) in the regulation of CD8 (show CD8A Proteins)(+) T cell expansion and effector function through transcriptional repression of Irf4.

  10. inhibition of IRF4 attenuates acute liver allograft rejection in mice, and this is associated with promoted M2 macrophage differentiation.

IRF4 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6\;14)(p25\;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with IRF4

  • interferon regulatory factor 4 (IRF4)
  • Interferon regulatory factor 4 (irf4)
  • interferon regulatory factor 4 (LOC100223845)
  • interferon regulatory factor 4 (Irf4)
  • interferon regulatory factor 4a (irf4a)
  • melanoma associated antigen (mutated) 1 (MUM1)
  • AI385587 protein
  • IRF-4 protein
  • irf4 protein
  • LSIRF protein
  • MUM1 protein
  • NF-EM5 protein
  • si:ch73-170d1.2 protein
  • Spip protein

Protein level used designations for IRF4

interferon regulatory factor 4 , Interferon regulatory factor 4 , lymphocyte-specific interferon regulatory factor , multiple myeloma oncogene 1 , NF-EM5 , PU.1 interaction partner , Sfpi1/PU.1 interaction partner , transcriptional activator PIP , irf4 , MUM-1 , PWWP domain-containing protein MUM1 , mutated melanoma-associated antigen 1

462386 Pan troglodytes
722883 Macaca mulatta
100194953 Salmo salar
100223845 Taeniopygia guttata
100590106 Nomascus leucogenys
3662 Homo sapiens
374179 Gallus gallus
100144625 Sus scrofa
16364 Mus musculus
291100 Rattus norvegicus
100002070 Danio rerio
612320 Canis lupus familiaris
513471 Bos taurus
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