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IRF4 protects arteries against neointima formation by promoting the expression of KLF4 (show KLF4 Proteins) by directly binding to its promoter.
We propose that the Irf4 locus functions as the "reader" of TCR signal strength, and in turn, concentration-dependent activity of Irf4 "writes" T helper fate choice.
PU.1-induced apoptosis in myeloma cells is associated with IRF4 downregulation and subsequent IRF7 (show IRF7 Proteins) upregulation.
GM-CSF (show CSF2 Proteins) can mediate inflammation and pain by regulating IRF4-induced CCL17 (show CCL17 Proteins) production
expression of CARMA1 (show CARD11 Proteins) mRNA is likely associated with the expression of MUM1 and shows male predominance in diffuse large B cell lymphoma.
Data show that BCL-6 (show BCL6 Proteins) (64%) and MUM1 (45%) were expressed in patients with primary mediastinal large B-cell lymphoma.
The study demonstrated differential MUM-1 expression between PEComas and other true melanocytic tumors
Mum-1 was positive in all but one case (96.7%) of systemic anaplastic large-cell lymphoma by tissue microarray immunohistochem analysis.
These results show that MUM1 is a strong and robust predictive immunohistochemical marker in patients with follicular lymphoma
MUM1 expression is reliable in the prognosis of diffuse large B-cell lymphoma.
this study shows that epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells
Cell fate and metabolic state are linked by transcriptional regulators, such as IRF4 and FoxO1 (show FOXO1 Proteins), with dual roles in lineage and metabolic choice. Instructing some cells to utilize nutrients for anabolism and differentiation while other cells catabolically self-digest and self-renew may enable growth and repair in metazoa.
Here the authors show that concomitant loss of Tet2 and Tet3 in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 expression and impaired the germline transcription and rearrangement of the Igkappa locus.
Data show that Fos-Related Antigen-2 (Fra-2 (show FOSL2 Proteins)) is a key upstream regulator of forkhead box O1 (Foxo1 (show FOXO1 Proteins)) and interferon regulatory factor 4 (Irf4) expression and influences proliferation and differentiation of B cells at multiple stages.
MTORC2 (show CRTC2 Proteins) operated in parallel with the IL-4Ralpha-Stat6 (show STAT6 Proteins) pathway.
IRF4 mRNA and protein expression was remarkably suppressed during the development of myeloid-derived suppressor cells in the tumor microenvironment. IRF4 expression in MDSCs can modulate their activity to inhibit T cell proliferation through IL-10 (show IL10 Proteins) production and ROS (show ROS1 Proteins) generation, and myeloid-specific deletion of IRF4 leads to the increase of MDSC differentiation. IRF4 reduction induced by tumors can increase MDSC numbers.
propose that Irf4 is imperative for thymic Treg homeostasis because it regulates thymic epithelial cell-specific expression of several chemokines and costimulatory molecules indicated in thymocyte development and Treg induction
MHC II(+) resident peritoneal and pleural macrophages are continuously replenished by blood monocytes recruited to the peritoneal and pleural cavities constitutively, starting after birth, where they require IRF4 and signals likely derived from the microbiome to fully differentiate.
IRF4a and IRF4b displayed a distinct tissue expression pattern, embryonic stages expression and inducible expression in vivo and in vitro, suggesting that IRF4 paralogues might play different roles in immune system.
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6\;14)(p25\;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
interferon regulatory factor 4
, Interferon regulatory factor 4
, lymphocyte-specific interferon regulatory factor
, multiple myeloma oncogene 1
, PU.1 interaction partner
, Sfpi1/PU.1 interaction partner
, transcriptional activator PIP
, PWWP domain-containing protein MUM1
, mutated melanoma-associated antigen 1