Browse our anti-ZAP70 (ZAP70) Antibodies

Full name:
anti-zeta-Chain (TCR) Associated Protein Kinase 70kDa Antibodies (ZAP70)
On www.antibodies-online.com are 563 zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) Antibodies from 33 different suppliers available. Additionally we are shipping ZAP70 Kits (20) and ZAP70 Proteins (11) and many more products for this protein. A total of 610 ZAP70 products are currently listed.
Synonyms:
70kDa, AI327364, MGC80670, MGC88962, mrtle, mur, SRK, STCD, STD, TZK, ZAP-70, ZAP70
list all antibodies Gene Name GeneID UniProt
ZAP70 22637 P43404
ZAP70 301348  
ZAP70 7535 P43403

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All available anti-ZAP70 Antibodies

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Top referenced anti-ZAP70 Antibodies

  1. Human Polyclonal ZAP70 Primary Antibody for IHC (p), WB - ABIN197384 : Salomon, Ficarro, Brill, Brinker, Phung, Ericson, Sauer, Brock, Horn, Schultz, Peters: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 6 references for 197384

  2. Human Polyclonal ZAP70 Primary Antibody for IF, WB - ABIN196884 : Ku, Yablonski, Manser, Lim, Weiss: A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. in The EMBO journal 2001 (PubMed)
    Show all 5 references for 196884

  3. Chicken Monoclonal ZAP70 Primary Antibody for IF, IP - ABIN967848 : Arpaia, Shahar, Dadi, Cohen, Roifman: Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. in Cell 1994 (PubMed)
    Show all 5 references for 967848

  4. Human Monoclonal ZAP70 Primary Antibody for FACS, IF - ABIN238530 : Schneider, Smith, Liu, Bismuth, Rudd: CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization. in European journal of immunology 2007 (PubMed)
    Show all 4 references for 238530

  5. Human Polyclonal ZAP70 Primary Antibody for IHC (p) - ABIN197386 : Chan, Dalton, Johnson, Kong, Wang, Thoma, Kurosaki: Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. in The EMBO journal 1995 (PubMed)
    Show all 3 references for 197386

  6. Human Polyclonal ZAP70 Primary Antibody for IHC (p), WB - ABIN196886 : Kong, Dalton, Bubeck Wardenburg, Straus, Kurosaki, Chan: Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. in Molecular and cellular biology 1996 (PubMed)
    Show all 3 references for 196886

  7. Human Polyclonal ZAP70 Primary Antibody for IHC, ELISA - ABIN1532002 : Chan, Iwashima, Turck, Weiss: ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. in Cell 1992 (PubMed)
    Show all 2 references for 1532002

  8. Human Polyclonal ZAP70 Primary Antibody for FACS, IHC (p) - ABIN658066 : Lin, Cheng, Huang, Lin, Yang: Zap70 controls the interaction of talin with integrin to regulate the chemotactic directionality of T-cell migration. in Molecular immunology 2010 (PubMed)
    Show all 2 references for 658066

  9. Human Polyclonal ZAP70 Primary Antibody for IHC (p), WB - ABIN658067 : Liu, Purbhoo, Davis, Rudd: SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 2 references for 658067

More Antibodies against ZAP70 Interaction Partners

Mouse (Murine) zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) interaction partners

  1. disruption of normal Zap70 autoinhibition engaged negative feedback mechanisms by which negative selection and inhibitory receptors restrain TCR signaling to enforce both central and peripheral tolerance.

  2. in this study, authors discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T-cell antigen receptors, which turned them into a 'catalytic unit' that amplified antigenic stimuli

  3. was significantly increased in 22-month AEW mice compared with 5-month AEW mice. ELISA data showed that secretions of IL-2 and NGF in 22-month AEW mice were higher than 5-month AEW mice. Our results indicate that increased ZAP70 is involved in dry skin in elderly pruritus. Increased secretion of IL-2 and NGF may induce dry skin itch.

  4. this study shows that ZAP-70 mutation has a strong impact on T cell-driven arthritis in SKG model regardless of the genetic background

  5. These findings establish Otud7b (show OTUD7B Antibodies) as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 function.

  6. Data suggest that ring finger protein 41 Nrdp1 (show RNF41 Antibodies) terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 kinase.

  7. Zap70 as a structural protein regulates integrin-mediated control of actin and with its catalytic activity regulates T cell receptor-mediated control of actin and membrane remodelling during formation of the immunological synapse.

  8. Blockade of CXCR7 (show CXCR7 Antibodies) suppressed MIF (show MIF Antibodies)-mediated ERK (show EPHB2 Antibodies)- and zeta-chain-associated protein kinase (show CDK7 Antibodies) (ZAP)-70 activation

  9. mediates the CD4 (show CD4 Antibodies) lineage differentiation in response to Class II selecting ligands

  10. In mice with spondylarthritis, microbiota content varied according to whether T cell receptor signal strength was normal or was impaired due to the ZAP-70(W163C) mutation.

Human zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) interaction partners

  1. ZAP-70 signaling was impaired by cholesterol depletion, further supporting the importance of membrane organization in TCR signaling.

  2. We conclude that ZAP70 plays a role for the homing to and/or the survival of ALL cells in the CNS and that ZAP70 may represent a therapeutic target. Furthermore, targeting CCR7 (show CCR7 Antibodies)/CXCR4 (show CXCR4 Antibodies) may be particularly promising in treating T-ALL.

  3. The aim of this study was to evaluate the expression of ZAP70 changing during disease progression, the intracellular interferon gamma (IFN-gamma (show IFNG Antibodies)) and IL-4 (show IL4 Antibodies) content of T and B lymphocytes and the CLL cell subset (CD5 (show CD5 Antibodies)+CD19 (show CD19 Antibodies)+) in CLL patients and healthy subjects, and ZAP70 correlation with cytokine production.

  4. in this study, authors discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T-cell antigen receptors, which turned them into a 'catalytic unit' that amplified antigenic stimuli

  5. The histological observations suggested that the patients represent diverse cases of NHL (show RTEL1 Antibodies) like mature B-cell type, mature T-cell type and high grade diffuse B-cell type NHL (show RTEL1 Antibodies). The findings indicate that patients with NHL (show RTEL1 Antibodies) may also be analyzed for status of PAX5 (show PAX5 Antibodies), CD19 (show CD19 Antibodies) and ZAP70, and their transcriptional and post-translational variants for the differential diagnosis of NHL (show RTEL1 Antibodies) and therapy.

  6. Compound heterozygous mutations in ZAP70 gene is associated with leaky severe combined immunodeficiency (show PRKDC Antibodies) disorder.

  7. The results suggest that genetic polymorphism in the 3' UTR (show UTS2R Antibodies) of ZAP-70 is associated with rheumatoid arthritis susceptibility in southern Taiwanese.

  8. Cellular studies with ZAP70 showed that multiple lipids bind its C-terminal SH2 domain in a spatiotemporally specific manner and thereby exert exquisite spatiotemporal control over its protein binding and signaling activities in T cells.

  9. Whole-exome sequencing performed on five family members revealed two affected siblings to be compound heterozygous for two unique missense mutations in the 70-kD T cell receptor zeta-chain associated protein (ZAP-70).

  10. The data suggest that ZO-1 (show TJP1 Antibodies), along with CD38 and Zap-70, plays a role in cell cycle regulation in chronic B cell leukemia, and may be used as a prognostic marker in the disease monitoring.

Cow (Bovine) zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) interaction partners

  1. The surface expression of CTLA-4 (show CTLA4 Antibodies) was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 were decreased in CD4 (show CD4 Antibodies)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.

ZAP70 Antigen Profile

Antigen Summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Alternative names and synonyms associated with ZAP70

  • zeta-chain (TCR) associated protein kinase 70kDa (zap70) antibody
  • zeta-chain (TCR) associated protein kinase 70kDa (ZAP70) antibody
  • tyrosine-protein kinase zap-70 (Smp_149470) antibody
  • zeta-chain (TCR) associated protein kinase (Zap70) antibody
  • zeta-chain (TCR) associated protein kinase 70 (Zap70) antibody
  • zeta-chain (TCR) associated protein kinase 70kDa (Zap70) antibody
  • 70kDa antibody
  • AI327364 antibody
  • MGC80670 antibody
  • MGC88962 antibody
  • mrtle antibody
  • mur antibody
  • SRK antibody
  • STCD antibody
  • STD antibody
  • TZK antibody
  • ZAP-70 antibody
  • ZAP70 antibody

Protein level used designations for ZAP70

zeta-chain (TCR) associated protein kinase 70kDa , zeta-chain associated protein kinase 70kDa , tyrosine-protein kinase zap-70 , tyrosine-protein kinase ZAP-70-like , 70 kDa zeta-associated protein , 70 kDa zeta-chain associated protein , syk-related tyrosine kinase , tyrosine-protein kinase ZAP-70 , syk-related protein tyrosine kinase , zeta-chain associated protein kinase, 70kD

GENE ID SPECIES
446840 Xenopus laevis
448557 Xenopus (Silurana) tropicalis
459427 Pan troglodytes
707555 Macaca mulatta
8343736 Schistosoma mansoni
100342021 Oryctolagus cuniculus
100390922 Callithrix jacchus
100451782 Pongo abelii
100542877 Meleagris gallopavo
100589243 Nomascus leucogenys
22637 Mus musculus
301348 Rattus norvegicus
7535 Homo sapiens
100271860 Canis lupus familiaris
100524930 Sus scrofa
504509 Bos taurus
100713473 Cavia porcellus
420086 Gallus gallus
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