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Browse our PCNA Proteins (PCNA)

Full name:
Proliferating Cell Nuclear Antigen Proteins (PCNA)
On are 38 Proliferating Cell Nuclear Antigen (PCNA) Proteins from 11 different suppliers available. Additionally we are shipping PCNA Antibodies (681) and PCNA Kits (52) and many more products for this protein. A total of 788 PCNA products are currently listed.
53/13, AO090003000846, cb16, CG9193, Dmel\\CG9193, DmPCNA, dPCNA, fb36g03, l(2)02448, l(2)56F, l(2)56Fa, l(2)s1534, Mus209, pcna, pcna-A, Pcna/cyclin, PCNA/mus209, PCNAR, wu:fa28e03, wu:fb36g03
list all proteins Gene Name GeneID UniProt
PCNA 5111 P12004
PCNA 18538 P17918
PCNA 25737 P04961

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PCNA Proteins (PCNA) by Origin

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Top referenced PCNA Proteins

  1. Human PCNA Protein expressed in Escherichia coli (E. coli) - ABIN667068 : Matsumoto, Moriuchi, Koji, Nakane: Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin. in The EMBO journal 1987 (PubMed)
    Show all 2 references for ABIN667068

  2. Human PCNA Protein expressed in Baculovirus infected Insect Cells - ABIN2005057 : Ducoux, Urbach, Baldacci, Hübscher, Koundrioukoff, Christensen, Hughes: Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. in The Journal of biological chemistry 2001 (PubMed)

More Proteins for PCNA Interaction Partners

Fruit Fly (Drosophila melanogaster) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. Results show that regulation of e2f1 (show E2F1 Proteins) and PCNA by DREF (show ZBED1 Proteins) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.

  2. crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A

  3. We observed that SUUR chromosomal localization changed along with PCNA pattern and these proteins largely co-localized during the late S-phase in salivary glands.

  4. E2F (show E2F2 Proteins) regulation of PCNA is dispensable for viability, but is nonetheless important for normal Drosophila development.

  5. A Q123V mutation dramaticly enhances the abilities of Drosophila PCNA to stimulate calf thymus pol delta (show POLD1 Proteins). Replacing the entire interdomain connector loop AA 119-133 with the corresponding residues from human PCNA results in additional enhancement.

Tomato (Solanum lycopersicum) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. tomato DDI2 gene is required for UV-induced DNA damage repair and plant tolerance to UV stress. [DDI2]

Human Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. Studies demonstrated that POLH (show POLH Proteins) interaction with PCNA plays an indispensable role in the recruitment of pol-eta to UV-induced cyclobutane pyrimidine dimers site to carry out translesion synthesis (TLS (show FUS Proteins)), and the dissociation of pol-eta from PCNA after TLS (show FUS Proteins) is essential for maintaining high fidelity DNA replication.

  2. PCNA is a substrate of the HSV-1 deubiquitinase UL36USP, which has previously been shown to be involved mainly in virus uptake and maturation

  3. Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling

  4. PCNA plays a critical role in preventing CAG repeat (show CELF3 Proteins) expansions by modulating the structures of dynamic DNA via cooperation with base excision repair enzymes.

  5. Replication protein A (show GPR153 Proteins) binds tightly to the single-stranded DNA adjacent to a blocked primer/template junction and restricts PCNA to the upstream duplex region by physically blocking diffusion of PCNA along ssDNA.

  6. These findings offer new insights into the determinants of PIP (show PIP Proteins) box for PCNA binding.

  7. collectively, this study uncovers a new role for CRL4CDT2 in protecting genomic integrity against replication stress via regulated proteolysis of PCNA-associated SDE2 and provides insights into how an integrated UBL domain within linear polypeptide sequence controls protein stability and function.

  8. The aim of this study is to analyze the immunoexpression of Ki67 (show MKI67 Proteins), p53 (show TP53 Proteins), MCM3 (show MCM3 Proteins) and PCNA markers in epithelial remnants of dental follicles of impacted teeth and to identify a possible correlation between the immunoexpression of these markers in dentigerous cysts and keratocystic odontogenic tumors.

  9. REV1 (show REV1 Proteins) promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18 (show RAD18 Proteins).

  10. USP7 (show USP7 Proteins) suppresses H2O2-induced mutagenesis involving cell-cycle-independent processes such as DNA repair.

Mouse (Murine) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18 (show RAD18 Proteins).

  2. PCNA was mainly localized in decidual-stromal cells.

  3. Luteolin may inhibit tumor angiogenesis and tumor cell proliferation by down-regulation of LFA- 3 and PCNA and up-regulation of ICAM-1 (show ICAM1 Proteins) in tumor tissue of tumor-bearing mice, thereby achieving its anti-tumor effect.

  4. Data suggest Usp1 (ubiquitin specific peptidase 1) down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Pcna and Fancd2 (Fanconi anemia complementation group D2).

  5. The aberrant DNA replication mediated by the PCNA-DNA pol-beta (show POLB Proteins) complex induces p53 (show TP53 Proteins)-dependent neuronal cell death

  6. Demonstrate that miR (show MLXIP Proteins)-376a regulates primordial follicle assembly by modulating the expression of Pcna.

  7. while interaction with PCNA was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers

  8. Styrax japonica glycoprotein increased diethylnitrosamine-induced PCNA activity.

  9. This study identifies a critical role for PCNA in adipose tissue development, and for the first time identifies a role of the core DNA replication machinery at the interface between proliferation and differentiation.

  10. Seaweed pigment glycoprotein reduced the expression of PCNA and Bcl2 (show BCL2 Proteins), which reduced proliferation of hepatocarcinoma cells.

Zebrafish Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. The expression of telomerase activity and TERT (show TERT Proteins) in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.

  2. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.

Pig (Porcine) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. There is a link between the intestinal detoxification system (CYP1A) & cell renewal system (PCNA). These two processes are inversely correlated in beta-naphthoflavone- exposed fish

Xenopus laevis Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. residue in PCNA that is essential to support destruction of all CRL4(Cdt2) substrates

  2. CRL4Cdt2 ubiquitin ligase directly associates with pcna through its C-terminal domain.

  3. PCNA monoubiquitylation serves as a molecular gas pedal that controls the speed of replisome movement during S phase.

  4. Immunodepletion of Swift PAX-interacting protein 1 (show PAXIP1 Proteins) from Xenopus extracts prevented efficient PCNA ubiquitination

  5. PCNA docking activates the pre-formed Cdt1-Cul4(DDB1) ligase complex. Thus, PCNA functions as a platform for Cdt1 destruction, ensuring efficient and temporally restricted inactivation of a key cell-cycle regulator.

PCNA Protein Profile

Protein Summary

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Alternative names and synonyms associated with PCNA

  • mutagen-sensitive 209 (mus209)
  • proliferating cell nuclear antigen (pcna)
  • proliferating cell nuclear antigen (pcnA)
  • proliferating cell nuclear antigen (ANI_1_512014)
  • proliferating cell nuclear antigen (AOR_1_1500154)
  • proliferating cell nuclear antigen (PCNA)
  • proliferating cell nuclear antigen (Pcna)
  • Proliferating cell nuclear antigen-like (MGC53867)
  • proliferating cell nuclear antigen-like (LOC100339381)
  • proliferating cell nuclear antigen1 (pcna1)
  • 53/13 protein
  • AO090003000846 protein
  • cb16 protein
  • CG9193 protein
  • Dmel\\CG9193 protein
  • DmPCNA protein
  • dPCNA protein
  • fb36g03 protein
  • l(2)02448 protein
  • l(2)56F protein
  • l(2)56Fa protein
  • l(2)s1534 protein
  • Mus209 protein
  • pcna protein
  • pcna-A protein
  • Pcna/cyclin protein
  • PCNA/mus209 protein
  • PCNAR protein
  • wu:fa28e03 protein
  • wu:fb36g03 protein

Protein level used designations for PCNA

CG9193-PA , CG9193-PB , Proliferating-cell-nuclear-antigen , mus209-PA , mus209-PB , proliferating cell nuclear antigen , proliferating-cell nuclear antigen , DNA polymerase delta auxiliary protein , cyclin , etID36690.10 , fa28e03 , proliferating cell nuclear antigen subtype1 , proliferating cell nuclear antigen subtype2 , proliferating cell nuclear antigen subtype3 , CL1137_1 , CL1137_1(454) , CL1137_1_ov , proliferative cell nuclear antigen

37290 Drosophila melanogaster
544248 Solanum lycopersicum
857128 Guillardia theta
2761382 Methanococcus maripaludis S2
4978203 Aspergillus niger CBS 513.88
5788447 Bigelowiella natans
5991960 Aspergillus oryzae RIB40
10447350 Cryptomonas paramecium
5111 Homo sapiens
18538 Mus musculus
25737 Rattus norvegicus
30678 Danio rerio
477166 Canis lupus familiaris
515499 Bos taurus
373984 Gallus gallus
692192 Sus scrofa
100713865 Cavia porcellus
443155 Ovis aries
692356 Bombyx mori
394328 Xenopus laevis
100689335 Cricetulus griseus
398425 Xenopus laevis
100339381 Oryctolagus cuniculus
542425 Zea mays
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