Browse our PCNA Proteins (PCNA)

Full name:
Proliferating Cell Nuclear Antigen Proteins (PCNA)
On are 38 Proliferating Cell Nuclear Antigen (PCNA) Proteins from 11 different suppliers available. Additionally we are shipping PCNA Antibodies (717) and PCNA Kits (53) and many more products for this protein. A total of 825 PCNA products are currently listed.
53/13, AO090003000846, cb16, CG9193, Dmel\\CG9193, DmPCNA, dPCNA, fb36g03, l(2)02448, l(2)56F, l(2)56Fa, l(2)s1534, Mus209, pcna, pcna-A, Pcna/cyclin, PCNA/mus209, PCNAR, wu:fa28e03, wu:fb36g03
list all proteins Gene Name GeneID UniProt
PCNA 5111 P12004
PCNA 18538 P17918
PCNA 25737 P04961

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PCNA Proteins (PCNA) by Origin

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Top referenced PCNA Proteins

  1. Human PCNA Protein expressed in Escherichia coli (E. coli) - ABIN667068 : Matsumoto, Moriuchi, Koji, Nakane: Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin. in The EMBO journal 1987 (PubMed)
    Show all 2 references for 667068

  2. Human PCNA Protein expressed in Baculovirus infected Insect Cells - ABIN2005057 : Ducoux, Urbach, Baldacci, Hübscher, Koundrioukoff, Christensen, Hughes: Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. in The Journal of biological chemistry 2001 (PubMed)

More Proteins for PCNA Interaction Partners

Fruit Fly (Drosophila melanogaster) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. Results show that regulation of e2f1 (show E2F1 Proteins) and PCNA by DREF (show ZBED1 Proteins) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.

  2. crystal of DmPCNA diffracted to 2.0 A resolution and belonged to space group H3, with unit-cell parameters a = b = 151.16, c = 38.28 A

  3. We observed that SUUR chromosomal localization changed along with PCNA pattern and these proteins largely co-localized during the late S-phase in salivary glands.

  4. E2F (show E2F2 Proteins) regulation of PCNA is dispensable for viability, but is nonetheless important for normal Drosophila development.

  5. A Q123V mutation dramaticly enhances the abilities of Drosophila PCNA to stimulate calf thymus pol delta (show POLD1 Proteins). Replacing the entire interdomain connector loop AA 119-133 with the corresponding residues from human PCNA results in additional enhancement.

Tomato (Solanum lycopersicum) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. tomato DDI2 gene is required for UV-induced DNA damage repair and plant tolerance to UV stress. [DDI2]

Human Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. Damage-induced fork reversal in mammalian cells requires PCNA ubiquitination, UBC13, and K63-linked polyubiquitin chains, previously involved in error-free damage tolerance. Fork reversal in vivo also requires ZRANB3 translocase activity and its interaction with polyubiquitinated PCNA, pinpointing ZRANB3 as a key effector of error-free DNA damage tolerance.

  2. Multiple studies provide evidence that PCNA lies at the center of the faithful duplication of eukaryotic genomes and therefore genome integrity. [review]

  3. Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp.

  4. Results suggest that the UNG2 N-terminus may serve as a flexible scaffold to tether PCNA and RPA at the replication fork, and that post-translational modifications on the UNG2 N-terminus disrupt formation of the PCNA-UNG2-RPA protein complex.

  5. ECRG2 (show SPINK7 Proteins) in combination with cisplatin (DDP (show TIMM8A Proteins)) can inhibit viability and induce apoptosis in esophageal cancer DDP (show TIMM8A Proteins)-resistant cells, possibly via upregulation of p53 (show TP53 Proteins) expression and downregulation of PCNA expression.

  6. Reduced affinity of PCNA(S228I) for specific clients causes subtle cellular defects in undamaged cells which likely contribute to the etiology of PCNA-associated DNA repair disorder (PARD). Analysis of the binding between PCNA and PCNA-interacting proteins (PIPs (show GPRASP1 Proteins)) shows that the S228I change dramatically impairs the majority of these interactions, including that of Cdt1 (show CDT1 Proteins), DNMT1 (show DNMT1 Proteins), PolD3(p66 (show POLD3 Proteins)) and PolD4(p12 (show POLD4 Proteins)).

  7. Data suggest that, during human DNA replication, restricting PCNA (proliferating cell nuclear antigen) to the vicinity of its DNA target site is important; PCNA can be maintained at or near primer/template junctions during DNA synthesis by RPA (show RPA1 Proteins) (replication protein A (show GPR153 Proteins)) or SSB (single-stranded DNA-binding protein (show RPA1 Proteins)); here, the SSB used was from Escherichia coli.

  8. Studies demonstrated that POLH (show POLH Proteins) interaction with PCNA plays an indispensable role in the recruitment of pol-eta to UV-induced cyclobutane pyrimidine dimers site to carry out translesion synthesis (TLS (show FUS Proteins)), and the dissociation of pol-eta from PCNA after TLS (show FUS Proteins) is essential for maintaining high fidelity DNA replication.

  9. PCNA is a substrate of the HSV-1 deubiquitinase UL36USP, which has previously been shown to be involved mainly in virus uptake and maturation

  10. Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling

Mouse (Murine) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Proteins)/NF-kappaB (show NFKB1 Proteins)-regulated apoptosis and the p53 (show TP53 Proteins)/PCNA- and ATM (show ATM Proteins)/ATR-Chk1 (show CHEK1 Proteins)/2-controlled DNA-damage response pathways.

  2. REV1 promote PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18 (show RAD18 Proteins).

  3. PCNA was mainly localized in decidual-stromal cells.

  4. Luteolin may inhibit tumor angiogenesis and tumor cell proliferation by down-regulation of LFA- 3 and PCNA and up-regulation of ICAM-1 (show ICAM1 Proteins) in tumor tissue of tumor-bearing mice, thereby achieving its anti-tumor effect.

  5. Data suggest Usp1 (ubiquitin specific peptidase 1) down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Pcna and Fancd2 (Fanconi anemia complementation group D2).

  6. The aberrant DNA replication mediated by the PCNA-DNA pol-beta (show POLB Proteins) complex induces p53 (show TP53 Proteins)-dependent neuronal cell death

  7. Demonstrate that miR (show MLXIP Proteins)-376a regulates primordial follicle assembly by modulating the expression of Pcna.

  8. while interaction with PCNA was important for targeting p21 to the CRL4Cdt2 ligase re-localized to MVM replication centers

  9. Styrax japonica glycoprotein increased diethylnitrosamine-induced PCNA activity.

  10. This study identifies a critical role for PCNA in adipose tissue development, and for the first time identifies a role of the core DNA replication machinery at the interface between proliferation and differentiation.

Zebrafish Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. The expression of telomerase activity and TERT (show TERT Proteins) in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.

  2. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.

Pig (Porcine) Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. There is a link between the intestinal detoxification system (CYP1A) & cell renewal system (PCNA). These two processes are inversely correlated in beta-naphthoflavone- exposed fish

Xenopus laevis Proliferating Cell Nuclear Antigen (PCNA) interaction partners

  1. residue in PCNA that is essential to support destruction of all CRL4(Cdt2) substrates

  2. CRL4Cdt2 ubiquitin ligase directly associates with pcna through its C-terminal domain.

  3. PCNA monoubiquitylation serves as a molecular gas pedal that controls the speed of replisome movement during S phase.

  4. Immunodepletion of Swift PAX-interacting protein 1 (show PAXIP1 Proteins) from Xenopus extracts prevented efficient PCNA ubiquitination

  5. PCNA docking activates the pre-formed Cdt1-Cul4(DDB1) ligase complex. Thus, PCNA functions as a platform for Cdt1 destruction, ensuring efficient and temporally restricted inactivation of a key cell-cycle regulator.

PCNA Protein Profile

Protein Summary

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

Alternative names and synonyms associated with PCNA

  • mutagen-sensitive 209 (mus209)
  • proliferating cell nuclear antigen (pcna)
  • proliferating cell nuclear antigen (pcnA)
  • proliferating cell nuclear antigen (ANI_1_512014)
  • proliferating cell nuclear antigen (AOR_1_1500154)
  • proliferating cell nuclear antigen (PCNA)
  • proliferating cell nuclear antigen (Pcna)
  • Proliferating cell nuclear antigen-like (MGC53867)
  • proliferating cell nuclear antigen-like (LOC100339381)
  • proliferating cell nuclear antigen1 (pcna1)
  • 53/13 protein
  • AO090003000846 protein
  • cb16 protein
  • CG9193 protein
  • Dmel\\CG9193 protein
  • DmPCNA protein
  • dPCNA protein
  • fb36g03 protein
  • l(2)02448 protein
  • l(2)56F protein
  • l(2)56Fa protein
  • l(2)s1534 protein
  • Mus209 protein
  • pcna protein
  • pcna-A protein
  • Pcna/cyclin protein
  • PCNA/mus209 protein
  • PCNAR protein
  • wu:fa28e03 protein
  • wu:fb36g03 protein

Protein level used designations for PCNA

CG9193-PA , CG9193-PB , Proliferating-cell-nuclear-antigen , mus209-PA , mus209-PB , proliferating cell nuclear antigen , proliferating-cell nuclear antigen , DNA polymerase delta auxiliary protein , cyclin , etID36690.10 , fa28e03 , proliferating cell nuclear antigen subtype1 , proliferating cell nuclear antigen subtype2 , proliferating cell nuclear antigen subtype3 , CL1137_1 , CL1137_1(454) , CL1137_1_ov , proliferative cell nuclear antigen

37290 Drosophila melanogaster
544248 Solanum lycopersicum
857128 Guillardia theta
2761382 Methanococcus maripaludis S2
4978203 Aspergillus niger CBS 513.88
5788447 Bigelowiella natans
5991960 Aspergillus oryzae RIB40
10447350 Cryptomonas paramecium
5111 Homo sapiens
18538 Mus musculus
25737 Rattus norvegicus
30678 Danio rerio
477166 Canis lupus familiaris
515499 Bos taurus
373984 Gallus gallus
692192 Sus scrofa
100713865 Cavia porcellus
443155 Ovis aries
692356 Bombyx mori
394328 Xenopus laevis
100689335 Cricetulus griseus
398425 Xenopus laevis
100339381 Oryctolagus cuniculus
542425 Zea mays
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