Browse our anti-Replication Protein A1, 70kDa (RPA1) Antibodies

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anti-Replication Protein A1, 70kDa Antibodies (RPA1)
On www.antibodies-online.com are 123 Replication Protein A1, 70kDa (RPA1) Antibodies from 24 different suppliers available. Additionally we are shipping Replication Protein A1, 70kDa Proteins (6) and Replication Protein A1, 70kDa Kits (4) and many more products for this protein. A total of 142 Replication Protein A1, 70kDa products are currently listed.
Synonyms:
70kDa, 5031405K23Rik, AA589576, AW557552, Cb1-727, CG9633, D-RPA70, D-SSB, Dmel\\CG9633, DmRPA, dmrpa1, dRP-A, HSSB, i164, LOC100230990, MST075, Mt-SSB, MtSSB, REPA1, RF-A, rp-a, Rpa, Rpa-70, RPA1, rpa70, RPA 70, RPA 70 kDa, Ssb-70, Ssbp1, wu:fi14b08, zgc:55337, zgc:77092
list all antibodies Gene Name GeneID UniProt
RPA1 68275 Q8VEE4
RPA1 287524  
RPA1 6117 P27694

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Top referenced anti-Replication Protein A1, 70kDa Antibodies

  1. Human Polyclonal RPA1 Primary Antibody for IHC (p), IHC - ABIN151627 : Thangavel, Mendoza-Maldonado, Tissino, Sidorova, Yin, Wang, Monnat, Falaschi, Vindigni: Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation. in Molecular and cellular biology 2010 (PubMed)
    Show all 6 references for 151627

  2. Yeast (Saccharomyces cerevisiae) Polyclonal RPA1 Primary Antibody for ChIP, IP - ABIN190714 : Chen, Lisby, Symington: RPA coordinates DNA end resection and prevents formation of DNA hairpins. in Molecular cell 2013 (PubMed)
    Show all 5 references for 190714

  3. Human Monoclonal RPA1 Primary Antibody for ICC, FACS - ABIN969564 : Sowd, Wang, Pretto, Chazin, Opresko: Replication protein A stimulates the Werner syndrome protein branch migration activity. in The Journal of biological chemistry 2009 (PubMed)

  4. Cow (Bovine) Polyclonal RPA1 Primary Antibody for WB - ABIN2786755 : Tomida, Masuda, Hiroaki, Ishikawa, Song, Tsurimoto, Tateishi, Shiomi, Kamei, Kim, Kamiya, Vaziri, Ohmori, Todo: DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex. in The Journal of biological chemistry 2008 (PubMed)

More Antibodies against Replication Protein A1, 70kDa Interaction Partners

Fruit Fly (Drosophila melanogaster) Replication Protein A1, 70kDa (RPA1) interaction partners

  1. loss-of-function alleles indicate that RPA is required to prevent neuroepithelial cells from differentiating into medulla neuroblasts

  2. Data show that the basic cleft of the RPA70 N-terminal OB-fold domain binds multiple checkpoint proteins, including RAD9, to promote ATR signaling.

Mouse (Murine) Replication Protein A1, 70kDa (RPA1) interaction partners

  1. The authors establish that a second Dna2-Rpa interaction is mutually exclusive with Rpa-DNA interactions and mediates the displacement of Rpa from ssDNA.

  2. LT prevents recruitment of RPA to nuclear foci after DNA damage. This leads to failure to recruit repair proteins such as Rad51 (show RAD51 Antibodies) or Rad9 (show RAD9A Antibodies), explaining why LT prevents repair of double strand DNA breaks by homologous recombination.

  3. Most RPA recruitment during class switch recombination represents salvage of unrepaired breaks by homology-based pathways during the S-G2 (show STRN3 Antibodies)/M phase of the cell cycle.

  4. POT1a (show POT1 Antibodies) degradation resulted in rapid and reversible activation of the ATR (show ATR Antibodies) pathway in G1 and S/G2 (show STRN3 Antibodies).

  5. Rpa1(L230P) missense mutation significantly alters the tumor phenotype and spectrum of Trp53 (show TP53 Antibodies) mutant mice by modifying the genetic mechanisms underlying tumorigenesis.

  6. both TNFR-p55 (show TNFRSF1A Antibodies) and TNFR (show TNFRSF1A Antibodies)-p75 (show NGFR Antibodies) appear to be of minimal importance for modulation of Fas (show FAS Antibodies)-mediated apoptosis and associated A1 protein expression despite normal Fas (show FAS Antibodies)/TNFR-p55 (show TNFRSF1A Antibodies) and increased TNFR (show TNFRSF1A Antibodies)-p75 (show NGFR Antibodies) expression in neutrophils

  7. Rpa1 functions in DNA metabolism are essential for the maintenance of chromosomal stability and tumor suppression.

  8. hyperphosphorylation may play a role in modulating cellular pathways by altering the DNA binding domain-mediated RPA-DNA and RPA-protein interactions, hypothetically via the interaction of hyperphosphorylated RPA32N with DBD-B

  9. These results demonstrate that neither RPA hyper-phosphorylation nor H2AX are required for the formation in RPA intra-nuclear foci in response to DNA damage/replicational stress.

Human Replication Protein A1, 70kDa (RPA1) interaction partners

  1. Results suggest that the UNG2 N-terminus may serve as a flexible scaffold to tether PCNA and RPA at the replication fork, and that post-translational modifications on the UNG2 N-terminus disrupt formation of the PCNA-UNG2-RPA protein complex.

  2. Data suggest RAD52 (show RAD52 Antibodies) binds tightly to RPA/ssDNA complex in presynaptic complex and inhibits RPA turnover; during presynaptic complex assembly, most of RPA and RAD52 (show RAD52 Antibodies) is displaced from ssDNA, but some RAD52 (show RAD52 Antibodies)/RPA/ssDNA complexes persist as interspersed clusters surrounded by RAD51 (show RAD51 Antibodies) filaments. (RAD52 (show RAD52 Antibodies) = Rad52 (show RAD52 Antibodies) DNA repair/recombination protein (show RAD50 Antibodies); RPA = replication protein A (show GPR153 Antibodies); ssDNA = single-stranded DNA; RAD51 (show RAD51 Antibodies) = Rad51 (show RAD51 Antibodies) recombinase (show RAG1 Antibodies))

  3. Data suggest that, during human DNA replication, restricting PCNA (proliferating cell nuclear antigen (show PCNA Antibodies)) to the vicinity of its DNA target site is important; PCNA (show PCNA Antibodies) can be maintained at or near primer/template junctions during DNA synthesis by RPA (replication protein A (show GPR153 Antibodies)) or SSB (single-stranded DNA-binding protein); here, the SSB used was from Escherichia coli.

  4. Strikingly, the addition of the single-stranded DNA (ssDNA)-binding replication protein A (RPA) selectively restores XPF-ERCC1 endonuclease activity on this structure. The 5'-3' exonuclease SNM1A can load from the XPF-ERCC1-RPA-induced incisions and digest past the crosslink to quantitatively complete the unhooking reaction.

  5. The authors have discovered a major sub-pathway of conventional long-patch base excision repair that involves formation of a 9-nucleotide gap 5' to the lesion. This new sub-pathway is mediated by RECQ1 (show RECQL Antibodies) DNA helicase and ERCC1 (show ERCC1 Antibodies)-XPF (show ERCC4 Antibodies) endonuclease in cooperation with PARP1 poly(ADP-ribose) polymerase (show PARP1 Antibodies) and RPA.

  6. RPA deficiency induces activation of the Fanconi anemia pathway in an ATR-dependent manner, which may play a role in the genome maintenance.

  7. Force regulated dynamics of RPA1 on a DNA fork during DNA replication has been reported.

  8. By monitoring DNA double-strand breaks mis (show AMH Antibodies)-repair using a sensitive bioassay, it was found that depletion of homologous recombination proteins, including BRCA2 (show BRCA2 Antibodies), BRCA1 or RPA1, resulted in a distinct mutational signature associated with significant increases in break-induced mutation frequencies.

  9. It has been concluded that stable binding and/or the melting of secondary DNA structures by RPA1 is required for DNA repair, including RAD51 (show RAD51 Antibodies)-mediated DNA strand exchange, but is dispensable for DNA replication.

  10. results reveal that ETAA1 is a novel RPA-interacting protein (show RPAIN Antibodies) that promotes restart of stalled replication forks.

Xenopus laevis Replication Protein A1, 70kDa (RPA1) interaction partners

  1. This study found that the N-terminus of the RPA large subunit interacts with both WRN and DNA2 (show DNA2 Antibodies) and is essential for stimulating WRN's 3'->5' helicase (show DNA2 Antibodies) activity and DNA2 (show DNA2 Antibodies)'s 5'->3' ss-DNA exonuclease (show EXO1 Antibodies) activity.

  2. The results provide strong biochemical evidence to link RPA to a specific DSB repair pathway and reveal a novel function of RPA in the generation of 3' ss-DNA for homology-dependent DSB repair.

  3. Replication protein A (show GPR153 Antibodies) accumulated increasingly on replication-arrested chromatin.

  4. RPA1 subunit may directly recognize and bind to the 5-formyluracil on the single-stranded DNA.

Replication Protein A1, 70kDa (RPA1) Antigen Profile

Antigen Summary

Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair\; it does not support chromosomal DNA replication and cell cycle progression through S- phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.

Alternative names and synonyms associated with Replication Protein A1, 70kDa (RPA1)

  • Replication Protein A 70 (RpA-70) antibody
  • replication protein A1, 70kDa (RPA1) antibody
  • replication protein A1, 70kDa (rpa1) antibody
  • replication protein A1, 70kDa (LOC100230990) antibody
  • replication protein A1 (LOC100341460) antibody
  • replication protein A1 (Rpa1) antibody
  • replication protein A1 (rpa1) antibody
  • Sjogren syndrome antigen B (autoantigen La) (SSB) antibody
  • uncharacterized LOC100298705 (LOC100298705) antibody
  • 70kDa antibody
  • 5031405K23Rik antibody
  • AA589576 antibody
  • AW557552 antibody
  • Cb1-727 antibody
  • CG9633 antibody
  • D-RPA70 antibody
  • D-SSB antibody
  • Dmel\\CG9633 antibody
  • DmRPA antibody
  • dmrpa1 antibody
  • dRP-A antibody
  • HSSB antibody
  • i164 antibody
  • LOC100230990 antibody
  • MST075 antibody
  • Mt-SSB antibody
  • MtSSB antibody
  • REPA1 antibody
  • RF-A antibody
  • rp-a antibody
  • Rpa antibody
  • Rpa-70 antibody
  • RPA1 antibody
  • rpa70 antibody
  • RPA 70 antibody
  • RPA 70 kDa antibody
  • Ssb-70 antibody
  • Ssbp1 antibody
  • wu:fi14b08 antibody
  • zgc:55337 antibody
  • zgc:77092 antibody

Protein level used designations for RPA1

CG9633-PA , RpA-70-PA , drosophila replication protein A , replication protein A 70 , single stranded-binding protein 70 , replication protein A1, 70kDa , replication protein A 70 kDa DNA-binding subunit , RF-A protein 1 , RP-A p70 , replication factor A protein 1 , replication protein A1 , replication protein A 70 kDa DNA-binding subunit-like , MSTP075 , single-stranded DNA-binding protein , replication protein A (RPA) , single-stranded DNA binding , single-stranded DNA-binding protein, mitochondrial

GENE ID SPECIES
40972 Drosophila melanogaster
454414 Pan troglodytes
491196 Canis lupus familiaris
504844 Bos taurus
548449 Xenopus (Silurana) tropicalis
100230990 Taeniopygia guttata
100302100 Ovis aries
100341460 Oryctolagus cuniculus
100402829 Callithrix jacchus
100481495 Ailuropoda melanoleuca
100525428 Sus scrofa
100585556 Nomascus leucogenys
68275 Mus musculus
287524 Rattus norvegicus
327491 Danio rerio
6117 Homo sapiens
417563 Gallus gallus
397937 Xenopus laevis
100173266 Pongo abelii
100008866 Oryctolagus cuniculus
100298705 Bos taurus
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